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- W4380742970 endingPage "104184" @default.
- W4380742970 startingPage "104184" @default.
- W4380742970 abstract "This study aimed to assess whether perinatal exposure to propiconazole (PRO), glyphosate (GLY) or their mixture (PROGLY) alters key endocrine pathways and the development of the male rat mammary gland. To this end, pregnant rats were orally exposed to vehicle, PRO, GLY, or a mixture of PRO and GLY from gestation day 9 until weaning. Male offspring were euthanized on postnatal day (PND) 21 and PND60. On PND21, GLY-exposed rats showed reduced mammary epithelial cell proliferation, whereas PRO-exposed ones showed increased ductal p-Erk1/2 expression without histomorphological alterations. On PND60, GLY-exposed rats showed reduced mammary gland area and estrogen receptor alpha expression and increased aromatase expression, whereas PRO-exposed ones showed enhanced lobuloalveolar development and increased lobular hyperplasia. However, PROGLY did not modify any of the endpoints evaluated. In summary, PRO and GLY modified the expression of key molecules and the development of the male mammary gland individually but not together." @default.
- W4380742970 created "2023-06-16" @default.
- W4380742970 creator A5010926582 @default.
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- W4380742970 creator A5082172591 @default.
- W4380742970 date "2023-08-01" @default.
- W4380742970 modified "2023-10-18" @default.
- W4380742970 title "Mammary gland development in male rats perinatally exposed to propiconazole, glyphosate, or their mixture" @default.
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