FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380757910> ?p ?o ?g. }

• W4380757910 abstract "Because of a steady increase in the detection of daptomycin-resistant (DAP-R) Staphylococcus aureus at three medical centres in Cologne, Germany, molecular surveillance was established from June 2016 to June 2018 to investigate the causes of the emergence and spread of respective isolates. Seventy-five S. aureus isolates, both DAP-R and DAP-susceptible, were collected from 42 patients for further analysis.Broth microdilution was used to determine the MICs for DAP and polyhexamethylene biguanide/polyhexanide (PHMB). To investigate the effect of PHMB on the development of DAP resistance, we performed selection experiments with PHMB. All isolates studied were subjected to whole-genome sequencing. Epidemiological, clinical, microbiological and molecular data were analysed comparatively.Acquisition of DAP resistance was mainly observed in patients with acute and chronic wounds (40/42, 96.2%) treated with antiseptic (32/42, 76.2%) rather than systemic antibiotic therapy using DAP or vancomycin (7/42, 16.7%). DAP-R S. aureus had a diverse genetic background; however, within individual patients, isolates were closely related. At least three potential transmission events were detected. Most DAP-R isolates had concomitant elevated MICs for PHMB (50/54, 92.6%), and in vitro selection experiments confirmed that PHMB treatment is capable of generating DAP resistance. DAP resistance could be linked to 12 different polymorphisms in the mprF gene in the majority of clinical isolates (52/54, 96.3%) as well as in all in vitro selected strains.DAP resistance in S. aureus can occur independently of prior antibiotic therapy and can be selected by PHMB. Therefore, wound treatment with PHMB may trigger individual resistance development associated with gain-of-function mutations in the mprF gene." @default.
• W4380757910 created "2023-06-16" @default.
• W4380757910 creator A5000989122 @default.
• W4380757910 creator A5023037772 @default.
• W4380757910 creator A5029807397 @default.
• W4380757910 creator A5052362989 @default.
• W4380757910 creator A5070392787 @default.
• W4380757910 creator A5071815350 @default.
• W4380757910 creator A5073723537 @default.
• W4380757910 creator A5086482722 @default.
• W4380757910 creator A5089845900 @default.
• W4380757910 date "2023-06-01" @default.
• W4380757910 modified "2023-09-27" @default.
• W4380757910 title "Investigating a possible link between antiseptic treatment and the increased occurrence of daptomycin-resistant Staphylococcus aureus" @default.
• W4380757910 cites W1994576782 @default.
• W4380757910 cites W2018406369 @default.
• W4380757910 cites W2036030366 @default.
• W4380757910 cites W2053956268 @default.
• W4380757910 cites W2084417263 @default.
• W4380757910 cites W2093504297 @default.
• W4380757910 cites W2103784452 @default.
• W4380757910 cites W2108643808 @default.
• W4380757910 cites W2109603174 @default.
• W4380757910 cites W2116671458 @default.
• W4380757910 cites W2120902911 @default.
• W4380757910 cites W2146894318 @default.
• W4380757910 cites W2157018267 @default.
• W4380757910 cites W2169200218 @default.
• W4380757910 cites W2170381465 @default.
• W4380757910 cites W2314649741 @default.
• W4380757910 cites W2314772000 @default.
• W4380757910 cites W2344750051 @default.
• W4380757910 cites W2583023778 @default.
• W4380757910 cites W2744033108 @default.
• W4380757910 cites W2780927528 @default.
• W4380757910 cites W2891217728 @default.
• W4380757910 cites W2948505256 @default.
• W4380757910 cites W3132716326 @default.
• W4380757910 cites W3156458251 @default.
• W4380757910 cites W3171351619 @default.
• W4380757910 cites W4225547418 @default.
• W4380757910 doi "https://doi.org/10.1016/j.cmi.2023.06.007" @default.
• W4380757910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37321393" @default.
• W4380757910 hasPublicationYear "2023" @default.
• W4380757910 type Work @default.
• W4380757910 citedByCount "0" @default.
• W4380757910 crossrefType "journal-article" @default.
• W4380757910 hasAuthorship W4380757910A5000989122 @default.
• W4380757910 hasAuthorship W4380757910A5023037772 @default.
• W4380757910 hasAuthorship W4380757910A5029807397 @default.
• W4380757910 hasAuthorship W4380757910A5052362989 @default.
• W4380757910 hasAuthorship W4380757910A5070392787 @default.
• W4380757910 hasAuthorship W4380757910A5071815350 @default.
• W4380757910 hasAuthorship W4380757910A5073723537 @default.
• W4380757910 hasAuthorship W4380757910A5086482722 @default.
• W4380757910 hasAuthorship W4380757910A5089845900 @default.
• W4380757910 hasConcept C114851261 @default.
• W4380757910 hasConcept C142724271 @default.
• W4380757910 hasConcept C176947019 @default.
• W4380757910 hasConcept C2778651397 @default.
• W4380757910 hasConcept C2778980435 @default.
• W4380757910 hasConcept C2779489039 @default.
• W4380757910 hasConcept C2780950330 @default.
• W4380757910 hasConcept C2781460226 @default.
• W4380757910 hasConcept C501593827 @default.
• W4380757910 hasConcept C523546767 @default.
• W4380757910 hasConcept C54355233 @default.
• W4380757910 hasConcept C71924100 @default.
• W4380757910 hasConcept C86803240 @default.
• W4380757910 hasConcept C89423630 @default.
• W4380757910 hasConcept C94665300 @default.
• W4380757910 hasConceptScore W4380757910C114851261 @default.
• W4380757910 hasConceptScore W4380757910C142724271 @default.
• W4380757910 hasConceptScore W4380757910C176947019 @default.
• W4380757910 hasConceptScore W4380757910C2778651397 @default.
• W4380757910 hasConceptScore W4380757910C2778980435 @default.
• W4380757910 hasConceptScore W4380757910C2779489039 @default.
• W4380757910 hasConceptScore W4380757910C2780950330 @default.
• W4380757910 hasConceptScore W4380757910C2781460226 @default.
• W4380757910 hasConceptScore W4380757910C501593827 @default.
• W4380757910 hasConceptScore W4380757910C523546767 @default.
• W4380757910 hasConceptScore W4380757910C54355233 @default.
• W4380757910 hasConceptScore W4380757910C71924100 @default.
• W4380757910 hasConceptScore W4380757910C86803240 @default.
• W4380757910 hasConceptScore W4380757910C89423630 @default.
• W4380757910 hasConceptScore W4380757910C94665300 @default.
• W4380757910 hasLocation W43807579101 @default.
• W4380757910 hasLocation W43807579102 @default.
• W4380757910 hasOpenAccess W4380757910 @default.
• W4380757910 hasPrimaryLocation W43807579101 @default.
• W4380757910 hasRelatedWork W1970719352 @default.
• W4380757910 hasRelatedWork W2009801005 @default.
• W4380757910 hasRelatedWork W2013134742 @default.
• W4380757910 hasRelatedWork W2018382434 @default.
• W4380757910 hasRelatedWork W2144963218 @default.
• W4380757910 hasRelatedWork W2151596649 @default.
• W4380757910 hasRelatedWork W2157018267 @default.
• W4380757910 hasRelatedWork W2539169413 @default.
• W4380757910 hasRelatedWork W2980950197 @default.
• W4380757910 hasRelatedWork W3195958508 @default.

• next