Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380758225> ?p ?o ?g. }
- W4380758225 endingPage "415" @default.
- W4380758225 startingPage "406" @default.
- W4380758225 abstract "To determine pathological changes of meibomian glands (MGs) after transient exposure of the rat eyelid margin to alkali solution. Filter paper infiltrated with 1 N sodium hydroxide solution was applied to the eyelid margin of Sprague-Dawley rats for 30 s under general anesthesia, without touching the conjunctiva, after which the ocular surface and eyelid margin were examined by slit-lamp microscopy. In vivo confocal microscopy and stereomicroscopy were subsequently applied to observe MG morphology on day 5, day 10 and day 30 post alkali injury. Eyelid cross-sections were processed for H&E staining, Oil red O staining and immunofluorescent staining. After alkali injury, there was marked plugging of MG orifices, telangiectasia and hypertrophy of the eyelid margin, while corneal epithelium was intact at post-injury days 5 and 10. However, 30 days after alkali injury, mild corneal epithelial damage was observed. Degeneration of MG acini was observed at days 5 and became aggravated at days 10 and 30, along with MG duct dilation and acini loss. Oil red O staining showed lipid accumulation in the dilated duct. Inflammatory cell infiltration and the presence of apoptotic cells was seen in the MG loci 5 days post injury, but diminished at days 10 and 30. Cytokeratin 10 expression was increased in dilated duct, while cytokeratin 14, PPAR-γ, Ki67 and LRIG1 expression were decreased in the acini of injured loci. Transitory alkali exposure of the rat eyelid margin obstructs the MG orifice and induces pathological changes of MG dysfunction." @default.
- W4380758225 created "2023-06-16" @default.
- W4380758225 creator A5001472309 @default.
- W4380758225 creator A5003551515 @default.
- W4380758225 creator A5016477165 @default.
- W4380758225 creator A5039567363 @default.
- W4380758225 creator A5043859119 @default.
- W4380758225 creator A5050350085 @default.
- W4380758225 creator A5053209536 @default.
- W4380758225 creator A5059634218 @default.
- W4380758225 creator A5061520023 @default.
- W4380758225 creator A5062310871 @default.
- W4380758225 creator A5090840161 @default.
- W4380758225 date "2023-07-01" @default.
- W4380758225 modified "2023-10-18" @default.
- W4380758225 title "Transitory alkali exposure on meibomian gland orifices induces meibomian gland dysfunction" @default.
- W4380758225 cites W1972519365 @default.
- W4380758225 cites W1972616187 @default.
- W4380758225 cites W1980835902 @default.
- W4380758225 cites W1986303388 @default.
- W4380758225 cites W2005151867 @default.
- W4380758225 cites W2005800753 @default.
- W4380758225 cites W2022479428 @default.
- W4380758225 cites W2032576485 @default.
- W4380758225 cites W2032976158 @default.
- W4380758225 cites W2038338078 @default.
- W4380758225 cites W2053113950 @default.
- W4380758225 cites W2057877840 @default.
- W4380758225 cites W2064190744 @default.
- W4380758225 cites W2072353008 @default.
- W4380758225 cites W2075750165 @default.
- W4380758225 cites W2079472571 @default.
- W4380758225 cites W2102699949 @default.
- W4380758225 cites W2143619267 @default.
- W4380758225 cites W2163785631 @default.
- W4380758225 cites W2172434371 @default.
- W4380758225 cites W2185860540 @default.
- W4380758225 cites W2223338173 @default.
- W4380758225 cites W2507306731 @default.
- W4380758225 cites W2520097406 @default.
- W4380758225 cites W2607003470 @default.
- W4380758225 cites W2737642784 @default.
- W4380758225 cites W2759617848 @default.
- W4380758225 cites W2767152267 @default.
- W4380758225 cites W2769177908 @default.
- W4380758225 cites W2883986429 @default.
- W4380758225 cites W2893499224 @default.
- W4380758225 cites W2973117724 @default.
- W4380758225 cites W3081838266 @default.
- W4380758225 cites W3194170053 @default.
- W4380758225 doi "https://doi.org/10.1016/j.jtos.2023.06.007" @default.
- W4380758225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37327868" @default.
- W4380758225 hasPublicationYear "2023" @default.
- W4380758225 type Work @default.
- W4380758225 citedByCount "0" @default.
- W4380758225 crossrefType "journal-article" @default.
- W4380758225 hasAuthorship W4380758225A5001472309 @default.
- W4380758225 hasAuthorship W4380758225A5003551515 @default.
- W4380758225 hasAuthorship W4380758225A5016477165 @default.
- W4380758225 hasAuthorship W4380758225A5039567363 @default.
- W4380758225 hasAuthorship W4380758225A5043859119 @default.
- W4380758225 hasAuthorship W4380758225A5050350085 @default.
- W4380758225 hasAuthorship W4380758225A5053209536 @default.
- W4380758225 hasAuthorship W4380758225A5059634218 @default.
- W4380758225 hasAuthorship W4380758225A5061520023 @default.
- W4380758225 hasAuthorship W4380758225A5062310871 @default.
- W4380758225 hasAuthorship W4380758225A5090840161 @default.
- W4380758225 hasConcept C105702510 @default.
- W4380758225 hasConcept C118487528 @default.
- W4380758225 hasConcept C142724271 @default.
- W4380758225 hasConcept C185592680 @default.
- W4380758225 hasConcept C2777165675 @default.
- W4380758225 hasConcept C2781302119 @default.
- W4380758225 hasConcept C71924100 @default.
- W4380758225 hasConcept C74864618 @default.
- W4380758225 hasConceptScore W4380758225C105702510 @default.
- W4380758225 hasConceptScore W4380758225C118487528 @default.
- W4380758225 hasConceptScore W4380758225C142724271 @default.
- W4380758225 hasConceptScore W4380758225C185592680 @default.
- W4380758225 hasConceptScore W4380758225C2777165675 @default.
- W4380758225 hasConceptScore W4380758225C2781302119 @default.
- W4380758225 hasConceptScore W4380758225C71924100 @default.
- W4380758225 hasConceptScore W4380758225C74864618 @default.
- W4380758225 hasLocation W43807582251 @default.
- W4380758225 hasLocation W43807582252 @default.
- W4380758225 hasOpenAccess W4380758225 @default.
- W4380758225 hasPrimaryLocation W43807582251 @default.
- W4380758225 hasRelatedWork W1559088909 @default.
- W4380758225 hasRelatedWork W2015806539 @default.
- W4380758225 hasRelatedWork W2397558157 @default.
- W4380758225 hasRelatedWork W2486808565 @default.
- W4380758225 hasRelatedWork W2594268031 @default.
- W4380758225 hasRelatedWork W2748952813 @default.
- W4380758225 hasRelatedWork W2899084033 @default.
- W4380758225 hasRelatedWork W2986698925 @default.
- W4380758225 hasRelatedWork W4206836504 @default.
- W4380758225 hasRelatedWork W3096865065 @default.
- W4380758225 hasVolume "29" @default.