Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380758701> ?p ?o ?g. }
- W4380758701 endingPage "175850" @default.
- W4380758701 startingPage "175850" @default.
- W4380758701 abstract "Asthma is a persistent respiratory ailment that displays periodicity and is linked to the equilibrium of T cells. Several compounds obtained from Chinese herbal medicines display beneficial impacts on T cell regulation and the attenuation of inflammatory mediator synthesis. Schisandrin A, an active lignan derived from the Schisandra fruit, exhibits anti-inflammatory characteristics. In the present study, the network analysis conducted revealed that the nuclear factor-kappaB (NF-κB) signaling pathway is likely a prominent contributor to the anti-asthmatic effects of schisandrin A. In addition, it has been established that the inhibition of cyclooxygenase 2 (COX-2/PTGS2) is likely a significant factor in this process. The results of in vitro experiments have substantiated that schisandrin A can effectively lower the expression of COX-2 and inducible nitric oxide synthase (iNOS) in 16 HBE cells and RAW264.7 cells in a manner that is dependent on the dosage administered. It was able to effectively reduce the activation of the NF-κB signaling pathway while simultaneously improving the injury to the epithelial barrier function. Furthermore, an investigation utilizing immune infiltration as a metric revealed an inequity in Th1/Th2 cells and a surge in Th2 cytokines in asthma patients. In the OVA-induced asthma mice model, it was observed that schisandrin A treatment effectively suppressed inflammatory cell infiltration, reduced the Th2 cell ratio, inhibited mucus secretion, and prevented airway remodeling. To summarize, the administration of schisandrin A has been found to effectively alleviate the symptoms of asthma by impeding the production of inflammation, which includes reducing the Th2 cell ratio and improving the integrity of the epithelial barrier function. These findings offer valuable insights into the potential therapeutic applications of schisandrin A for the treatment of asthma." @default.
- W4380758701 created "2023-06-16" @default.
- W4380758701 creator A5000172750 @default.
- W4380758701 creator A5004721149 @default.
- W4380758701 creator A5014947716 @default.
- W4380758701 creator A5039398152 @default.
- W4380758701 creator A5050089664 @default.
- W4380758701 creator A5067580959 @default.
- W4380758701 creator A5072587567 @default.
- W4380758701 creator A5073117170 @default.
- W4380758701 creator A5082056818 @default.
- W4380758701 date "2023-08-01" @default.
- W4380758701 modified "2023-09-27" @default.
- W4380758701 title "Schisandrin A ameliorates airway inflammation in model of asthma by attenuating Th2 response" @default.
- W4380758701 cites W1534551308 @default.
- W4380758701 cites W1837564390 @default.
- W4380758701 cites W1972837952 @default.
- W4380758701 cites W1980105210 @default.
- W4380758701 cites W2017988098 @default.
- W4380758701 cites W2020537288 @default.
- W4380758701 cites W2033591223 @default.
- W4380758701 cites W2034537627 @default.
- W4380758701 cites W2036597854 @default.
- W4380758701 cites W2045670373 @default.
- W4380758701 cites W2049695853 @default.
- W4380758701 cites W2054540776 @default.
- W4380758701 cites W2059167937 @default.
- W4380758701 cites W2066003502 @default.
- W4380758701 cites W2076944278 @default.
- W4380758701 cites W2078387296 @default.
- W4380758701 cites W2087448081 @default.
- W4380758701 cites W2090327604 @default.
- W4380758701 cites W2092762767 @default.
- W4380758701 cites W2096560421 @default.
- W4380758701 cites W2106577271 @default.
- W4380758701 cites W2108366700 @default.
- W4380758701 cites W2122076069 @default.
- W4380758701 cites W2122683221 @default.
- W4380758701 cites W2138024058 @default.
- W4380758701 cites W2142198527 @default.
- W4380758701 cites W2148356965 @default.
- W4380758701 cites W2149728359 @default.
- W4380758701 cites W2157076853 @default.
- W4380758701 cites W2159675211 @default.
- W4380758701 cites W2175536691 @default.
- W4380758701 cites W2223828059 @default.
- W4380758701 cites W2284187872 @default.
- W4380758701 cites W2315204759 @default.
- W4380758701 cites W2346651667 @default.
- W4380758701 cites W2474747771 @default.
- W4380758701 cites W2549456711 @default.
- W4380758701 cites W2611425558 @default.
- W4380758701 cites W2720897370 @default.
- W4380758701 cites W2731034157 @default.
- W4380758701 cites W2746717617 @default.
- W4380758701 cites W2768366016 @default.
- W4380758701 cites W2782209482 @default.
- W4380758701 cites W2810608004 @default.
- W4380758701 cites W2912116772 @default.
- W4380758701 cites W2939247829 @default.
- W4380758701 cites W2949174534 @default.
- W4380758701 cites W2954918427 @default.
- W4380758701 cites W2957444086 @default.
- W4380758701 cites W2967595695 @default.
- W4380758701 cites W2980465010 @default.
- W4380758701 cites W2987977290 @default.
- W4380758701 cites W2990310321 @default.
- W4380758701 cites W2994775658 @default.
- W4380758701 cites W3008739331 @default.
- W4380758701 cites W3010891774 @default.
- W4380758701 cites W3029798783 @default.
- W4380758701 cites W3047762934 @default.
- W4380758701 cites W3093194543 @default.
- W4380758701 cites W3095512706 @default.
- W4380758701 cites W3107527779 @default.
- W4380758701 cites W3112052973 @default.
- W4380758701 cites W3113635093 @default.
- W4380758701 cites W3118504473 @default.
- W4380758701 cites W3126448597 @default.
- W4380758701 cites W3131191175 @default.
- W4380758701 cites W3157014630 @default.
- W4380758701 cites W3186178071 @default.
- W4380758701 cites W4200580859 @default.
- W4380758701 cites W4232958701 @default.
- W4380758701 cites W4285733068 @default.
- W4380758701 doi "https://doi.org/10.1016/j.ejphar.2023.175850" @default.
- W4380758701 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37329976" @default.
- W4380758701 hasPublicationYear "2023" @default.
- W4380758701 type Work @default.
- W4380758701 citedByCount "0" @default.
- W4380758701 crossrefType "journal-article" @default.
- W4380758701 hasAuthorship W4380758701A5000172750 @default.
- W4380758701 hasAuthorship W4380758701A5004721149 @default.
- W4380758701 hasAuthorship W4380758701A5014947716 @default.
- W4380758701 hasAuthorship W4380758701A5039398152 @default.
- W4380758701 hasAuthorship W4380758701A5050089664 @default.
- W4380758701 hasAuthorship W4380758701A5067580959 @default.
- W4380758701 hasAuthorship W4380758701A5072587567 @default.