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• W4380768503 abstract "Objective To investigate the prevalence of smokeless tobacco (SLT) use in the Pan-American Health Organization (PAHO) region and its association with head and neck cancer and oral leukoplakia. Study Design We performed a search in nine databases (PubMed, Scopus, Embase, Web of Science, SciELo, LILACS, IBECS, BBO-ODONTOLOGIA, and PAHO-IRIS) and grey literature to identify targeted observational studies. The Joanna Briggs Institute Critical Appraisal Checklist was used to evaluate the risk of bias. The GRADE tool was also used to assess the certainty of evidence among the outcomes. A proportion and binary meta-analysis were performed to investigate the overall prevalence and associations. Results Fifty-nine studies were included, representing six PAHO countries. The SLT prevalence was 15% (95% CI:11.93-18.69); 17% (95% CI:13.25-22.65) of adults, and 11% (95% CI:8.54-14.78) of pediatric patients living in the PAHO region consume SLT. Head and neck cancer (OR= 1.98, 95%CI:1.54-2.55) and oral leukoplakia (OR= 8.38; 95%CI:1.05-67.25) showed a positive association with SLT use. Conclusions The available evidence showed a 15% SLT consumption in the PAHO region with a different distribution between the countries. A positive association for head and neck development in adults supports the harmful effects caused by SLT use. To investigate the prevalence of smokeless tobacco (SLT) use in the Pan-American Health Organization (PAHO) region and its association with head and neck cancer and oral leukoplakia. We performed a search in nine databases (PubMed, Scopus, Embase, Web of Science, SciELo, LILACS, IBECS, BBO-ODONTOLOGIA, and PAHO-IRIS) and grey literature to identify targeted observational studies. The Joanna Briggs Institute Critical Appraisal Checklist was used to evaluate the risk of bias. The GRADE tool was also used to assess the certainty of evidence among the outcomes. A proportion and binary meta-analysis were performed to investigate the overall prevalence and associations. Fifty-nine studies were included, representing six PAHO countries. The SLT prevalence was 15% (95% CI:11.93-18.69); 17% (95% CI:13.25-22.65) of adults, and 11% (95% CI:8.54-14.78) of pediatric patients living in the PAHO region consume SLT. Head and neck cancer (OR= 1.98, 95%CI:1.54-2.55) and oral leukoplakia (OR= 8.38; 95%CI:1.05-67.25) showed a positive association with SLT use. The available evidence showed a 15% SLT consumption in the PAHO region with a different distribution between the countries. A positive association for head and neck development in adults supports the harmful effects caused by SLT use." @default.
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• W4380768503 date "2023-07-01" @default.
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• W4380768503 title "SMOKELESS TOBACCO USE AND ASSOCIATION WITH HEAD AND NECK CANCER AND LEUKOPLAKIA IN A PAN-AMERICAN REGION: A META-ANALYSIS" @default.
• W4380768503 doi "https://doi.org/10.1016/j.oooo.2023.03.090" @default.
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