Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380769056> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W4380769056 abstract "Introduction: Trastuzumab (TRZ) has been broadly used as a chemotherapeutic agent for the treatment of advanced human epidermal growth factor receptor type 2-expressing malignancies. However, cardiotoxicity exacerbated by TRA has become an adverse clinical manifestation of oncologic treatment. Although cardioprotective outcomes of a mitochondrial division inhibitor (Mdivi-1) have been demonstrated for a wide range of cardiovascular pathologies, the anti-cardiotoxic effects of Mdivi-1 against TRZ are unknown. Hypothesis: Treatment with Mdivi-1 rescues cardiac mitochondrial dysfunction, resulting in improved left ventricular (LV) function in rats with TRZ-induced cardiotoxicity. Methods: Male Wistar rats (n=18) were divided into either TRZ group (4 mg/kg/day for 7 days, I.P., n=12) or control group (CON, n=6). In the TRZ group, rats also received one of the following co-treatments: 1) vehicle (VEH, n=6) or 2) Mdivi-1 (MDV, 1.2 mg/kg/day, n=6) via I.P. injection for 7 days. LV ejection fraction (LVEF) and cardiac mitochondrial function were determined. Results: TRZ-treated rats had impaired cardiac mitochondrial function as shown by increased reactive oxygen species (ROS) production, mitochondrial depolarization (reduced red/green fluorescence intensity), and mitochondrial swelling (reduced absorbance intensity), leading to LV dysfunction (75% LVEF for TRZ vs. 88% LVEF for CON) (Fig. 1A-D). Mdivi-1 co-treatment attenuated cardiac mitochondrial dysfunction and LV dysfunction as evidenced by a decrease in ROS, mitochondrial depolarization, mitochondrial swelling, and increased LVEF (83%, 11% improvement from VEH group) (Fig. 1A-D). Conclusions: Mdivi-1 effectively protected the heart against TRZ-induced cardiotoxicity by attenuating mitochondrial and LV dysfunction, thus indicating that pharmacological inhibition of mitochondrial fission could be a novel anti-cardiotoxicity in TRZ-induced cardiotoxicity." @default.
- W4380769056 created "2023-06-16" @default.
- W4380769056 creator A5004434966 @default.
- W4380769056 creator A5006772140 @default.
- W4380769056 creator A5013795191 @default.
- W4380769056 creator A5030219645 @default.
- W4380769056 creator A5053432872 @default.
- W4380769056 creator A5057021825 @default.
- W4380769056 creator A5058771185 @default.
- W4380769056 creator A5068465361 @default.
- W4380769056 creator A5068701746 @default.
- W4380769056 creator A5086148814 @default.
- W4380769056 date "2022-11-08" @default.
- W4380769056 modified "2023-09-24" @default.
- W4380769056 title "Abstract 9418: Inhibition of Cardiac Mitochondrial Fission as an Effective Intervention Against Trastuzumab-Induced Cardiotoxicity in Rats" @default.
- W4380769056 doi "https://doi.org/10.1161/circ.146.suppl_1.9418" @default.
- W4380769056 hasPublicationYear "2022" @default.
- W4380769056 type Work @default.
- W4380769056 citedByCount "0" @default.
- W4380769056 crossrefType "journal-article" @default.
- W4380769056 hasAuthorship W4380769056A5004434966 @default.
- W4380769056 hasAuthorship W4380769056A5006772140 @default.
- W4380769056 hasAuthorship W4380769056A5013795191 @default.
- W4380769056 hasAuthorship W4380769056A5030219645 @default.
- W4380769056 hasAuthorship W4380769056A5053432872 @default.
- W4380769056 hasAuthorship W4380769056A5057021825 @default.
- W4380769056 hasAuthorship W4380769056A5058771185 @default.
- W4380769056 hasAuthorship W4380769056A5068465361 @default.
- W4380769056 hasAuthorship W4380769056A5068701746 @default.
- W4380769056 hasAuthorship W4380769056A5086148814 @default.
- W4380769056 hasConcept C111566952 @default.
- W4380769056 hasConcept C126322002 @default.
- W4380769056 hasConcept C164705383 @default.
- W4380769056 hasConcept C17619807 @default.
- W4380769056 hasConcept C2776151105 @default.
- W4380769056 hasConcept C2776694085 @default.
- W4380769056 hasConcept C2778175917 @default.
- W4380769056 hasConcept C2778198053 @default.
- W4380769056 hasConcept C2778233292 @default.
- W4380769056 hasConcept C28859421 @default.
- W4380769056 hasConcept C48349386 @default.
- W4380769056 hasConcept C55493867 @default.
- W4380769056 hasConcept C71924100 @default.
- W4380769056 hasConcept C78085059 @default.
- W4380769056 hasConcept C86803240 @default.
- W4380769056 hasConcept C98274493 @default.
- W4380769056 hasConceptScore W4380769056C111566952 @default.
- W4380769056 hasConceptScore W4380769056C126322002 @default.
- W4380769056 hasConceptScore W4380769056C164705383 @default.
- W4380769056 hasConceptScore W4380769056C17619807 @default.
- W4380769056 hasConceptScore W4380769056C2776151105 @default.
- W4380769056 hasConceptScore W4380769056C2776694085 @default.
- W4380769056 hasConceptScore W4380769056C2778175917 @default.
- W4380769056 hasConceptScore W4380769056C2778198053 @default.
- W4380769056 hasConceptScore W4380769056C2778233292 @default.
- W4380769056 hasConceptScore W4380769056C28859421 @default.
- W4380769056 hasConceptScore W4380769056C48349386 @default.
- W4380769056 hasConceptScore W4380769056C55493867 @default.
- W4380769056 hasConceptScore W4380769056C71924100 @default.
- W4380769056 hasConceptScore W4380769056C78085059 @default.
- W4380769056 hasConceptScore W4380769056C86803240 @default.
- W4380769056 hasConceptScore W4380769056C98274493 @default.
- W4380769056 hasIssue "Suppl_1" @default.
- W4380769056 hasLocation W43807690561 @default.
- W4380769056 hasOpenAccess W4380769056 @default.
- W4380769056 hasPrimaryLocation W43807690561 @default.
- W4380769056 hasRelatedWork W2361407492 @default.
- W4380769056 hasRelatedWork W2363366439 @default.
- W4380769056 hasRelatedWork W2371199711 @default.
- W4380769056 hasRelatedWork W2386991455 @default.
- W4380769056 hasRelatedWork W2390396046 @default.
- W4380769056 hasRelatedWork W2786814199 @default.
- W4380769056 hasRelatedWork W2915561147 @default.
- W4380769056 hasRelatedWork W2995162523 @default.
- W4380769056 hasRelatedWork W2995550907 @default.
- W4380769056 hasRelatedWork W3194998566 @default.
- W4380769056 hasVolume "146" @default.
- W4380769056 isParatext "false" @default.
- W4380769056 isRetracted "false" @default.
- W4380769056 workType "article" @default.