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- W4380785853 abstract "Objective: To determine whether purinergic signaling plays a role in the adverse outcome in females presenting for cardiac surgery Methods: Right atrial tissue was harvested from 80 patients undergoing CABG surgery before and after and cardiopulmonary bypass (CBP). Human tissue experimentation was complemented by experiments in mice subject to a high fat diet and ovariectomy. Western blot and immunohistochemistry was carried out to interrogate the molecular derangements. Results: Females (n=40) had increased diastolic dysfunction (56% vs. 31%, p = .034) and length of stay (7.9 vs. 5.4 days, p = .02). We found that CD39, responsible for the enzymatic lysis of inflammatory extracellular ATP, was significantly decreased in women after CBP. Moreover, female patients demonstrated increased expression of ADORA2B, which acts as a pro-fibrotic agent responsive to adenosine as well as increased CD73, which is responsible for the lysis of adenosine monophosphate into adenosine. Finally, females demonstrated decreased adenosine deaminase, which breaks adenosine into inosine. Female patients had increased fibrosis and decreased angiogenesis (Figure 1a). Mouse models showed a similar decrease in purinergic ectonucleotidase activity as a result of ovariectomy and estrogen loss when compared to controls (Figure 1b). Conclusions: Purinergic signaling may serve as a key upstream mechanism responsible for the molecular derangements which underlie poorer outcomes for women following CABG surgery." @default.
- W4380785853 created "2023-06-16" @default.
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- W4380785853 date "2022-11-08" @default.
- W4380785853 modified "2023-09-24" @default.
- W4380785853 title "Abstract 15260: Role Of Purinergic Dysfunction in Worsened Outcomes for Females Undergoing Cardiac Surgery" @default.
- W4380785853 doi "https://doi.org/10.1161/circ.146.suppl_1.15260" @default.
- W4380785853 hasPublicationYear "2022" @default.
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