Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380788265> ?p ?o ?g. }
- W4380788265 abstract "Myeloid-derived suppressor cells (MDSCs) expand when the body undergoes inflammatory diseases and chronic diseases. However, its role in intervertebral disc degeneration remains unclear. The present study aimed to characterize specific subsets of MDSCs as potential indicators of disease progression in patients with lumbar disc herniation (LDH). The Gene Expression Omnibus (GEO) database was used to analyze the changes in granulocyte MDSCs (G-MDSCs). Peripheral blood samples were collected from 40 patients with LDH and 15 healthy controls, and flow cytometry was used to characterize different subsets of MDSCs. All subjects underwent lumbar spine magnetic resonance imaging. Then, t-distributed stochastic neighborhood embedding and FlowSOM were used to analyze the data obtained by CytoFlex. The correlation between circulating MDSCs and the clinicopathological stage of LDH was then further analyzed. The GEO database predicted that G-MDSCs were highly expressed in patients with LDH. The frequency of circulating G-MDSCs increased with Pfirrmann stage III and IV, while the percentage of mononuclear MDSCs (M-MDSCs) only increased. Patient age and sex did not correlate with the frequency of circulating G-MDSCs and M-MDSCs. The results of the computer algorithm analysis were consistent with those of our manual gating. The present study showed that the occurrence of LDH led to changes in the MDSC subpopulation in the circulating peripheral blood of patients, and the frequency of circulating G-MDSCs in patients with clinical stage III and IV LDH increased with the degree of degeneration. The determination of G-MDSCs can be used as an auxiliary examination item for LDH." @default.
- W4380788265 created "2023-06-16" @default.
- W4380788265 creator A5005123718 @default.
- W4380788265 creator A5015651736 @default.
- W4380788265 creator A5025014474 @default.
- W4380788265 creator A5026682288 @default.
- W4380788265 creator A5062875328 @default.
- W4380788265 creator A5065992719 @default.
- W4380788265 creator A5074943036 @default.
- W4380788265 date "2023-06-15" @default.
- W4380788265 modified "2023-09-27" @default.
- W4380788265 title "Increased levels of circulating granulocytic myeloid‑derived suppressor cells in lumbar disc herniation" @default.
- W4380788265 cites W1581789105 @default.
- W4380788265 cites W166857858 @default.
- W4380788265 cites W1968545383 @default.
- W4380788265 cites W1973890827 @default.
- W4380788265 cites W2021449823 @default.
- W4380788265 cites W2023772479 @default.
- W4380788265 cites W2033557491 @default.
- W4380788265 cites W2044971687 @default.
- W4380788265 cites W2047825133 @default.
- W4380788265 cites W2048442741 @default.
- W4380788265 cites W2064199385 @default.
- W4380788265 cites W2068650785 @default.
- W4380788265 cites W2074295411 @default.
- W4380788265 cites W2092798278 @default.
- W4380788265 cites W2107871413 @default.
- W4380788265 cites W2138383018 @default.
- W4380788265 cites W2150073466 @default.
- W4380788265 cites W2167810128 @default.
- W4380788265 cites W2229658487 @default.
- W4380788265 cites W2255522521 @default.
- W4380788265 cites W2316053538 @default.
- W4380788265 cites W2741922778 @default.
- W4380788265 cites W2804264564 @default.
- W4380788265 cites W2898591181 @default.
- W4380788265 cites W2913153613 @default.
- W4380788265 cites W2915104822 @default.
- W4380788265 cites W2969608376 @default.
- W4380788265 cites W3001331092 @default.
- W4380788265 cites W3005025575 @default.
- W4380788265 cites W3081941048 @default.
- W4380788265 cites W3086910654 @default.
- W4380788265 cites W3126790071 @default.
- W4380788265 cites W3168735175 @default.
- W4380788265 cites W3183539757 @default.
- W4380788265 cites W3199730550 @default.
- W4380788265 cites W4200021357 @default.
- W4380788265 cites W4220981239 @default.
- W4380788265 cites W4225557913 @default.
- W4380788265 cites W4240037531 @default.
- W4380788265 cites W4287030684 @default.
- W4380788265 cites W4307344150 @default.
- W4380788265 cites W2921208891 @default.
- W4380788265 doi "https://doi.org/10.3892/etm.2023.12066" @default.
- W4380788265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37408862" @default.
- W4380788265 hasPublicationYear "2023" @default.
- W4380788265 type Work @default.
- W4380788265 citedByCount "0" @default.
- W4380788265 crossrefType "journal-article" @default.
- W4380788265 hasAuthorship W4380788265A5005123718 @default.
- W4380788265 hasAuthorship W4380788265A5015651736 @default.
- W4380788265 hasAuthorship W4380788265A5025014474 @default.
- W4380788265 hasAuthorship W4380788265A5026682288 @default.
- W4380788265 hasAuthorship W4380788265A5062875328 @default.
- W4380788265 hasAuthorship W4380788265A5065992719 @default.
- W4380788265 hasAuthorship W4380788265A5074943036 @default.
- W4380788265 hasBestOaLocation W43807882651 @default.
- W4380788265 hasConcept C121608353 @default.
- W4380788265 hasConcept C126322002 @default.
- W4380788265 hasConcept C137061746 @default.
- W4380788265 hasConcept C142724271 @default.
- W4380788265 hasConcept C179185449 @default.
- W4380788265 hasConcept C202751555 @default.
- W4380788265 hasConcept C203014093 @default.
- W4380788265 hasConcept C2779282312 @default.
- W4380788265 hasConcept C2781018059 @default.
- W4380788265 hasConcept C29537977 @default.
- W4380788265 hasConcept C553184892 @default.
- W4380788265 hasConcept C55493867 @default.
- W4380788265 hasConcept C55721878 @default.
- W4380788265 hasConcept C71924100 @default.
- W4380788265 hasConcept C86803240 @default.
- W4380788265 hasConceptScore W4380788265C121608353 @default.
- W4380788265 hasConceptScore W4380788265C126322002 @default.
- W4380788265 hasConceptScore W4380788265C137061746 @default.
- W4380788265 hasConceptScore W4380788265C142724271 @default.
- W4380788265 hasConceptScore W4380788265C179185449 @default.
- W4380788265 hasConceptScore W4380788265C202751555 @default.
- W4380788265 hasConceptScore W4380788265C203014093 @default.
- W4380788265 hasConceptScore W4380788265C2779282312 @default.
- W4380788265 hasConceptScore W4380788265C2781018059 @default.
- W4380788265 hasConceptScore W4380788265C29537977 @default.
- W4380788265 hasConceptScore W4380788265C553184892 @default.
- W4380788265 hasConceptScore W4380788265C55493867 @default.
- W4380788265 hasConceptScore W4380788265C55721878 @default.
- W4380788265 hasConceptScore W4380788265C71924100 @default.
- W4380788265 hasConceptScore W4380788265C86803240 @default.
- W4380788265 hasIssue "2" @default.
- W4380788265 hasLocation W43807882651 @default.