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- W4380788269 abstract "Systemic treatment with immunotherapy or targeted therapy can significantly improve survival in patients with advanced (metastatic or high-risk) melanoma. Fifty percent of patients with melanoma have a BRAF mutation. Decisions on optimal sequencing of systemic treatments should take into account drug- and tumor-related factors and patient characteristics. Although the combination of ipilimumab and nivolumab is associated with the best survival outcomes, it is associated with significant toxicity. Targeted therapy may be a more favorable option in certain clinical situations. We review the literature on immunotherapy and targeted therapy in melanoma and present an algorithm for guiding decision-making on their use as first-line systemic treatments for advanced BRAF-mutated melanoma." @default.
- W4380788269 created "2023-06-16" @default.
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- W4380788269 date "2023-06-01" @default.
- W4380788269 modified "2023-09-26" @default.
- W4380788269 title "Inmunoterapia vs terapia diana en el paciente con melanoma. Avanzado y mutación braf v600, ¿por cuál comenzar?" @default.
- W4380788269 doi "https://doi.org/10.1016/j.ad.2023.05.023" @default.
- W4380788269 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37321549" @default.
- W4380788269 hasPublicationYear "2023" @default.
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