Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380788944> ?p ?o ?g. }
- W4380788944 endingPage "1582" @default.
- W4380788944 startingPage "1582" @default.
- W4380788944 abstract "Blastocystis hominis is an intestinal protozoan that is often neglected, despite causing abdominal pain and diarrhea. Previous research has demonstrated that lipids can be synthesized by B. hominis or can accumulate in growth medium, but their function and mechanisms in the pathogenesis of Blastocystis remain unclear. Our study found that lipid-rich Blastocystis ST7-B can increase inflammation and disrupt Caco-2 cells more than the same parasite without the lipovenoes supplement. Additionally, the cysteine protease of Blastocystis, a virulence factor, is upregulated and has higher activity in lipid-rich Blastocystis. In order to better understand the effects of lipids on Blastocystis pathogenesis, we treated lipid-lowering pravastatin during Blastocystis ST7-B culturing with a lipovenoes supplement, which decreased the lipid levels of the Blastocystis and reduced the Blastocystis-induced inflammation and cell disruption of Caco-2 cells. We also analyzed the fatty acid composition and possible synthesis pathway in Blastocystis ST7-B, finding significantly higher ratios of arachidonic acid, oleic acid, and palmitic acid than in the other lipid components in lipid-rich Blastocystis ST7-B. These results suggest that lipids play a significant role in the pathogenesis of Blastocystis and provide important information on the molecular mechanisms of and potential treatments for Blastocystis infection." @default.
- W4380788944 created "2023-06-16" @default.
- W4380788944 creator A5007008037 @default.
- W4380788944 creator A5018055568 @default.
- W4380788944 creator A5038719850 @default.
- W4380788944 creator A5042225506 @default.
- W4380788944 creator A5059641397 @default.
- W4380788944 creator A5064978093 @default.
- W4380788944 date "2023-06-14" @default.
- W4380788944 modified "2023-09-30" @default.
- W4380788944 title "Lipid Accumulation in Blastocystis Increases Cell Damage in Co-Cultured Cells" @default.
- W4380788944 cites W1590526322 @default.
- W4380788944 cites W1799873623 @default.
- W4380788944 cites W1820161030 @default.
- W4380788944 cites W1968124718 @default.
- W4380788944 cites W1971772314 @default.
- W4380788944 cites W1973166997 @default.
- W4380788944 cites W1979603320 @default.
- W4380788944 cites W1982283178 @default.
- W4380788944 cites W1986407659 @default.
- W4380788944 cites W1987354436 @default.
- W4380788944 cites W1990924771 @default.
- W4380788944 cites W1991340024 @default.
- W4380788944 cites W1991522326 @default.
- W4380788944 cites W1991680568 @default.
- W4380788944 cites W1991918472 @default.
- W4380788944 cites W1995744752 @default.
- W4380788944 cites W2005582290 @default.
- W4380788944 cites W2006556033 @default.
- W4380788944 cites W2009972285 @default.
- W4380788944 cites W2016997092 @default.
- W4380788944 cites W2020594996 @default.
- W4380788944 cites W2020643325 @default.
- W4380788944 cites W2031310028 @default.
- W4380788944 cites W2061077466 @default.
- W4380788944 cites W2063297728 @default.
- W4380788944 cites W2063367588 @default.
- W4380788944 cites W2068225057 @default.
- W4380788944 cites W2068705497 @default.
- W4380788944 cites W2076021419 @default.
- W4380788944 cites W2078557216 @default.
- W4380788944 cites W2089371584 @default.
- W4380788944 cites W2089798761 @default.
- W4380788944 cites W2102382814 @default.
- W4380788944 cites W2104497826 @default.
- W4380788944 cites W2110861405 @default.
- W4380788944 cites W2113882016 @default.
- W4380788944 cites W2115119126 @default.
- W4380788944 cites W2116269514 @default.
- W4380788944 cites W2117748799 @default.
- W4380788944 cites W2125710056 @default.
- W4380788944 cites W2141599510 @default.
- W4380788944 cites W2154922504 @default.
- W4380788944 cites W2157848005 @default.
- W4380788944 cites W2160616422 @default.
- W4380788944 cites W2163632018 @default.
- W4380788944 cites W2169494411 @default.
- W4380788944 cites W2219245394 @default.
- W4380788944 cites W2338977280 @default.
- W4380788944 cites W2346547000 @default.
- W4380788944 cites W2402932721 @default.
- W4380788944 cites W2472370041 @default.
- W4380788944 cites W2485412989 @default.
- W4380788944 cites W2509163005 @default.
- W4380788944 cites W2604988176 @default.
- W4380788944 cites W2790360897 @default.
- W4380788944 cites W2801510008 @default.
- W4380788944 doi "https://doi.org/10.3390/microorganisms11061582" @default.
- W4380788944 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37375084" @default.
- W4380788944 hasPublicationYear "2023" @default.
- W4380788944 type Work @default.
- W4380788944 citedByCount "0" @default.
- W4380788944 crossrefType "journal-article" @default.
- W4380788944 hasAuthorship W4380788944A5007008037 @default.
- W4380788944 hasAuthorship W4380788944A5018055568 @default.
- W4380788944 hasAuthorship W4380788944A5038719850 @default.
- W4380788944 hasAuthorship W4380788944A5042225506 @default.
- W4380788944 hasAuthorship W4380788944A5059641397 @default.
- W4380788944 hasAuthorship W4380788944A5064978093 @default.
- W4380788944 hasBestOaLocation W43807889441 @default.
- W4380788944 hasConcept C181199279 @default.
- W4380788944 hasConcept C203014093 @default.
- W4380788944 hasConcept C2778078955 @default.
- W4380788944 hasConcept C2778092740 @default.
- W4380788944 hasConcept C2780942790 @default.
- W4380788944 hasConcept C2781403372 @default.
- W4380788944 hasConcept C55493867 @default.
- W4380788944 hasConcept C61716771 @default.
- W4380788944 hasConcept C86803240 @default.
- W4380788944 hasConcept C89423630 @default.
- W4380788944 hasConceptScore W4380788944C181199279 @default.
- W4380788944 hasConceptScore W4380788944C203014093 @default.
- W4380788944 hasConceptScore W4380788944C2778078955 @default.
- W4380788944 hasConceptScore W4380788944C2778092740 @default.
- W4380788944 hasConceptScore W4380788944C2780942790 @default.
- W4380788944 hasConceptScore W4380788944C2781403372 @default.
- W4380788944 hasConceptScore W4380788944C55493867 @default.
- W4380788944 hasConceptScore W4380788944C61716771 @default.