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- W4380789976 abstract "Human thirty-eight-negative kinase-1 (TNK1) is implicated in cancer progression. The TNK1-UBA domain binds polyubiquitin and plays a regulatory role in TNK1 activity and stability. Sequence analysis suggests an unusual architecture for the TNK1 UBA domain, but an experimentally-validated molecular structure is undetermined. To gain insight into TNK1 regulation, we fused the UBA domain to the 1TEL crystallization chaperone and obtained crystals diffracting as far as 1.53 Å. A 1TEL search model enabled solution of the X-ray phases. GG and GSGG linkers allowed the UBA to reproducibly find a productive binding mode against its host 1TEL polymer and to crystallize at protein concentrations as low as 0.1 mg/mL. Our studies support a mechanism of TELSAM fusion crystallization and show that TELSAM fusion crystals require fewer crystal contacts than traditional protein crystals. Modeling and experimental validation suggest the UBA domain may be selective for both the length and linkages of polyubiquitin chains." @default.
- W4380789976 created "2023-06-16" @default.
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- W4380789976 date "2023-06-14" @default.
- W4380789976 modified "2023-10-14" @default.
- W4380789976 title "Fusion crystallization reveals the behavior of both the 1TEL crystallization chaperone and the TNK1 UBA domain" @default.
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- W4380789976 doi "https://doi.org/10.1101/2023.06.14.544429" @default.
- W4380789976 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37398013" @default.
- W4380789976 hasPublicationYear "2023" @default.
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