Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380791371> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W4380791371 abstract "The adaptive dynamics of evolving microbial populations takes place on a complex fitness landscape generated by epistatic interactions. The population generically consists of multiple competing strains, a phenomenon known as clonal interference. Microscopic epistasis and clonal interference are central aspects of evolution in microbes, but their combined effects on the functional form of the population’s mean fitness are poorly understood. Here, we develop a computational method that resolves the full microscopic complexity of an evolving population subject to a standard serial dilution protocol. We find that stronger microscopic epistasis gives rise to fitness trajectories with slower growth independent of the number of competing strains, which we quantify with power-law fits and understand mechanistically via a random walk model that neglects dynamical correlations between genes. We show that clonal interference leads to fitness trajectories with faster growth (in functional form) without microscopic epistasis, but has a negligible effect when epistasis is sufficiently strong, indicating that the role of clonal interference depends intimately on the underlying fitness landscape." @default.
- W4380791371 created "2023-06-16" @default.
- W4380791371 creator A5031046135 @default.
- W4380791371 creator A5054972412 @default.
- W4380791371 creator A5058784998 @default.
- W4380791371 creator A5080479523 @default.
- W4380791371 date "2023-06-15" @default.
- W4380791371 modified "2023-10-04" @default.
- W4380791371 title "How microscopic epistasis and clonal interference shape the fitness trajectory in a spin glass model of microbial long-term evolution" @default.
- W4380791371 doi "https://doi.org/10.7554/elife.87895.1" @default.
- W4380791371 hasPublicationYear "2023" @default.
- W4380791371 type Work @default.
- W4380791371 citedByCount "0" @default.
- W4380791371 crossrefType "posted-content" @default.
- W4380791371 hasAuthorship W4380791371A5031046135 @default.
- W4380791371 hasAuthorship W4380791371A5054972412 @default.
- W4380791371 hasAuthorship W4380791371A5058784998 @default.
- W4380791371 hasAuthorship W4380791371A5080479523 @default.
- W4380791371 hasBestOaLocation W43807913711 @default.
- W4380791371 hasConcept C104317684 @default.
- W4380791371 hasConcept C121332964 @default.
- W4380791371 hasConcept C121864883 @default.
- W4380791371 hasConcept C127162648 @default.
- W4380791371 hasConcept C144024400 @default.
- W4380791371 hasConcept C149923435 @default.
- W4380791371 hasConcept C2908647359 @default.
- W4380791371 hasConcept C2910387474 @default.
- W4380791371 hasConcept C2988562018 @default.
- W4380791371 hasConcept C31258907 @default.
- W4380791371 hasConcept C32022120 @default.
- W4380791371 hasConcept C41008148 @default.
- W4380791371 hasConcept C54355233 @default.
- W4380791371 hasConcept C61727976 @default.
- W4380791371 hasConcept C78458016 @default.
- W4380791371 hasConcept C86803240 @default.
- W4380791371 hasConcept C87590526 @default.
- W4380791371 hasConcept C91852762 @default.
- W4380791371 hasConceptScore W4380791371C104317684 @default.
- W4380791371 hasConceptScore W4380791371C121332964 @default.
- W4380791371 hasConceptScore W4380791371C121864883 @default.
- W4380791371 hasConceptScore W4380791371C127162648 @default.
- W4380791371 hasConceptScore W4380791371C144024400 @default.
- W4380791371 hasConceptScore W4380791371C149923435 @default.
- W4380791371 hasConceptScore W4380791371C2908647359 @default.
- W4380791371 hasConceptScore W4380791371C2910387474 @default.
- W4380791371 hasConceptScore W4380791371C2988562018 @default.
- W4380791371 hasConceptScore W4380791371C31258907 @default.
- W4380791371 hasConceptScore W4380791371C32022120 @default.
- W4380791371 hasConceptScore W4380791371C41008148 @default.
- W4380791371 hasConceptScore W4380791371C54355233 @default.
- W4380791371 hasConceptScore W4380791371C61727976 @default.
- W4380791371 hasConceptScore W4380791371C78458016 @default.
- W4380791371 hasConceptScore W4380791371C86803240 @default.
- W4380791371 hasConceptScore W4380791371C87590526 @default.
- W4380791371 hasConceptScore W4380791371C91852762 @default.
- W4380791371 hasLocation W43807913711 @default.
- W4380791371 hasOpenAccess W4380791371 @default.
- W4380791371 hasPrimaryLocation W43807913711 @default.
- W4380791371 hasRelatedWork W2039865984 @default.
- W4380791371 hasRelatedWork W2050856169 @default.
- W4380791371 hasRelatedWork W2126263906 @default.
- W4380791371 hasRelatedWork W2515676979 @default.
- W4380791371 hasRelatedWork W2892105358 @default.
- W4380791371 hasRelatedWork W2953017728 @default.
- W4380791371 hasRelatedWork W3086862203 @default.
- W4380791371 hasRelatedWork W3146958471 @default.
- W4380791371 hasRelatedWork W4316511358 @default.
- W4380791371 hasRelatedWork W4322720191 @default.
- W4380791371 isParatext "false" @default.
- W4380791371 isRetracted "false" @default.
- W4380791371 workType "article" @default.