FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380792022> ?p ?o ?g. }

• W4380792022 abstract "Abstract An ovalbumin (OVA)-induced allergic rhinitis (AR) mouse model was established to investigate whether quercetin (QUE) treats AR via TLR4/MyD88/IRAK4 signaling pathway. SPF grade Balb/c mice were randomly divided into 4 groups: normal control (NC), OVA, dexamethasone (DEX), and (QUE) groups. OVA and aluminum hydroxide [AL(OH) 3 ] were injected intraperitoneally for basic sensitization and OVA was dripped into the nose for challenge to induce a mouse model of AR. The mice were scored by observing the behaviors of scratching, sneezing and runny nose to assess whether the modeling was successful. The treatment groups (DEX and QUE) were given the corresponding drugs for gavage treatment for 1 week after successful modeling, and the OVA and NC groups were treated with normal saline instead. The levels of OVA-IgE, IL-4, IL-13, IL-1β, IL-17 and IL-10 in serum were measured by enzyme-linked immunosorbent assay (ELISA); the changes of mice nasal mucosa were observed in hematoxylin-eosin (HE) stained histopathological sections; the relative expression levels of mRNA and protein of TLR4, MyD88, IRAK4, NF-κB in lung tissues were measured by quantitative real-time PCR (qPCR) and western blot, respectively; the changes in the percentages of regulatory T cells (Treg) and helper T cells 17 (Th17) in splenocytes were detected by flow cytometry. The results showed that the allergic symptoms scores were greater than 10 points and the expression levels of OVA-IgE, IL-4, IL-13, IL-1β and IL-17 in the serum increased and the expression level of IL-10 decreased in the OVA group compared with NC group. HE staining of the nasal cavity suggested detachment and necrosis of the nasal mucosa, tissue edema, and inflammatory cell infiltration in the OVA group. The relative expression levels of mRNA and protein of TLR4, MyD88, IRAK4, NF-κB in lung tissues were increased and the percentage of Treg cells decreased and the percentage of Th17 cells increased in splenocytes of the OVA group. Based on these results, we speculate that QUE may inhibit inflammatory responses and induce immune tolerance via TLR4/MyD88/IRAK4 signaling pathway in mice model of AR." @default.
• W4380792022 created "2023-06-16" @default.
• W4380792022 creator A5001665283 @default.
• W4380792022 creator A5001937247 @default.
• W4380792022 creator A5009638692 @default.
• W4380792022 creator A5020904199 @default.
• W4380792022 creator A5021295478 @default.
• W4380792022 creator A5037527356 @default.
• W4380792022 creator A5038371279 @default.
• W4380792022 creator A5069050556 @default.
• W4380792022 creator A5092177550 @default.
• W4380792022 date "2023-06-15" @default.
• W4380792022 modified "2023-09-25" @default.
• W4380792022 title "The role and mechanism of quercetin via TLR4/MyD88/IRAK4 signaling pathway in the treatment of allergic rhinitis" @default.
• W4380792022 cites W2746154185 @default.
• W4380792022 cites W2806045085 @default.
• W4380792022 cites W2809132731 @default.
• W4380792022 cites W2883085934 @default.
• W4380792022 cites W2884403858 @default.
• W4380792022 cites W2901071407 @default.
• W4380792022 cites W2912624893 @default.
• W4380792022 cites W2914949223 @default.
• W4380792022 cites W2943909458 @default.
• W4380792022 cites W3027012949 @default.
• W4380792022 cites W3029614763 @default.
• W4380792022 cites W3031181626 @default.
• W4380792022 cites W3105089752 @default.
• W4380792022 cites W3110567498 @default.
• W4380792022 cites W3128930788 @default.
• W4380792022 cites W3177207393 @default.
• W4380792022 cites W3178963741 @default.
• W4380792022 cites W3184443603 @default.
• W4380792022 cites W3193507903 @default.
• W4380792022 cites W4211003574 @default.
• W4380792022 cites W4225535320 @default.
• W4380792022 cites W4229553561 @default.
• W4380792022 cites W4285090470 @default.
• W4380792022 cites W4365138646 @default.
• W4380792022 doi "https://doi.org/10.21203/rs.3.rs-3029080/v1" @default.
• W4380792022 hasPublicationYear "2023" @default.
• W4380792022 type Work @default.
• W4380792022 citedByCount "0" @default.
• W4380792022 crossrefType "posted-content" @default.
• W4380792022 hasAuthorship W4380792022A5001665283 @default.
• W4380792022 hasAuthorship W4380792022A5001937247 @default.
• W4380792022 hasAuthorship W4380792022A5009638692 @default.
• W4380792022 hasAuthorship W4380792022A5020904199 @default.
• W4380792022 hasAuthorship W4380792022A5021295478 @default.
• W4380792022 hasAuthorship W4380792022A5037527356 @default.
• W4380792022 hasAuthorship W4380792022A5038371279 @default.
• W4380792022 hasAuthorship W4380792022A5069050556 @default.
• W4380792022 hasAuthorship W4380792022A5092177550 @default.
• W4380792022 hasBestOaLocation W43807920221 @default.
• W4380792022 hasConcept C104317684 @default.
• W4380792022 hasConcept C126322002 @default.
• W4380792022 hasConcept C141105273 @default.
• W4380792022 hasConcept C159654299 @default.
• W4380792022 hasConcept C185592680 @default.
• W4380792022 hasConcept C189976730 @default.
• W4380792022 hasConcept C203014093 @default.
• W4380792022 hasConcept C207480886 @default.
• W4380792022 hasConcept C2776070231 @default.
• W4380792022 hasConcept C2776217527 @default.
• W4380792022 hasConcept C2776415932 @default.
• W4380792022 hasConcept C2776914184 @default.
• W4380792022 hasConcept C2776946954 @default.
• W4380792022 hasConcept C2778070265 @default.
• W4380792022 hasConcept C2779675166 @default.
• W4380792022 hasConcept C2780401358 @default.
• W4380792022 hasConcept C553184892 @default.
• W4380792022 hasConcept C55493867 @default.
• W4380792022 hasConcept C71924100 @default.
• W4380792022 hasConcept C8891405 @default.
• W4380792022 hasConcept C98274493 @default.
• W4380792022 hasConceptScore W4380792022C104317684 @default.
• W4380792022 hasConceptScore W4380792022C126322002 @default.
• W4380792022 hasConceptScore W4380792022C141105273 @default.
• W4380792022 hasConceptScore W4380792022C159654299 @default.
• W4380792022 hasConceptScore W4380792022C185592680 @default.
• W4380792022 hasConceptScore W4380792022C189976730 @default.
• W4380792022 hasConceptScore W4380792022C203014093 @default.
• W4380792022 hasConceptScore W4380792022C207480886 @default.
• W4380792022 hasConceptScore W4380792022C2776070231 @default.
• W4380792022 hasConceptScore W4380792022C2776217527 @default.
• W4380792022 hasConceptScore W4380792022C2776415932 @default.
• W4380792022 hasConceptScore W4380792022C2776914184 @default.
• W4380792022 hasConceptScore W4380792022C2776946954 @default.
• W4380792022 hasConceptScore W4380792022C2778070265 @default.
• W4380792022 hasConceptScore W4380792022C2779675166 @default.
• W4380792022 hasConceptScore W4380792022C2780401358 @default.
• W4380792022 hasConceptScore W4380792022C553184892 @default.
• W4380792022 hasConceptScore W4380792022C55493867 @default.
• W4380792022 hasConceptScore W4380792022C71924100 @default.
• W4380792022 hasConceptScore W4380792022C8891405 @default.
• W4380792022 hasConceptScore W4380792022C98274493 @default.
• W4380792022 hasLocation W43807920221 @default.
• W4380792022 hasOpenAccess W4380792022 @default.
• W4380792022 hasPrimaryLocation W43807920221 @default.
• W4380792022 hasRelatedWork W1604871015 @default.
• W4380792022 hasRelatedWork W2004286520 @default.

• next