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- W4380792381 abstract "Pancreatic ductal adenocarcinoma (PDAC) is a type of cancer with a high mortality rate. Current treatments for PDACs often have side effects, and drug resistance in cancer stem cells (CSCs) would be also a problem. Cyclic guanosine monophosphate (cGMP) suppresses the mitochondrial function of PDACs and inhibits their CSC properties. Metabolic regulation plays a crucial role in the maintenance of CSC phenotype, and we hypothesized that cGMP induction suppresses cancer stem cell properties in the cancer cell through energy-related signaling pathways. We demonstrated that induction of cGMP upregulated the PPARα/PDK4 pathway and suppressed CSC properties in PDAC, and patients with pancreatic cancer with high PDK4 gene expression had a better prognosis than those with low gene expression. Therefore, these mechanisms may provide new therapeutic targets for the eradication of pancreatic CSCs." @default.
- W4380792381 created "2023-06-16" @default.
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- W4380792381 date "2023-09-01" @default.
- W4380792381 modified "2023-10-15" @default.
- W4380792381 title "PPAR/PDK4 pathway is involved in the anticancer effects of cGMP in pancreatic cancer" @default.
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- W4380792381 doi "https://doi.org/10.1016/j.bbrc.2023.06.043" @default.
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