FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380792789> ?p ?o ?g. }

• W4380792789 endingPage "164906" @default.
• W4380792789 startingPage "164906" @default.
• W4380792789 abstract "The variety of activities carried out within hospitals results in their final discharges being considered hotspots for the emission of emerging pollutants. Hospital effluents contain different substances capable of altering the health of ecosystems and biota, furthermore, little research has been done to elucidate the adverse effects of these anthropogenic matrices. Taking this into account, herein we aimed to establish whether exposure to different proportions (2 %, 2.5 %, 3 %, and 3.5 %) of hospital effluent treated by hospital wastewater treatment plant (HWWTP) can induce oxidative stress, behavioral alterations, neurotoxicity, and disruption of gene expression in Danio rerio brain. Our results demonstrate that the hospital effluent under-study induces an anxiety-like state and alters swimming behavior, as fish exhibited increased freezing episodes, erratic movements and traveled less distance than the control group. In addition, after exposure we observed a meaningful rise in biomarkers related to oxidative damage, such as protein carbonyl content (PCC), lipoperoxidation level (LPX), hydroperoxide content (HPC), as well as an increase in enzyme antioxidant activities of catalase (CAT), and superoxide dismutase (SOD) upon short-term exposure. Moreover, we discovered an inhibition of acetylcholinesterase (AChE) activity in a hospital effluent proportion-dependent manner. Regarding gene expression, a significant disruption of genes related to antioxidant response (cat, sod, nrf2), apoptosis (casp6, bax, casp9), and detoxification (cyp1a1) was observed. In conclusion, our outcomes suggest that hospital effluents enhance the emergence of oxidative molecules, and promote a highly oxidative environment at the neuronal level that favors the inhibition of AChE activity, which consequently explains the anxiety-like behavior observed in D. rerio adults. Lastly, our research sheds light on possible toxicodynamic mechanism by which these anthropogenic matrices may trigger damage in D. rerio brain." @default.
• W4380792789 created "2023-06-16" @default.
• W4380792789 creator A5032812469 @default.
• W4380792789 creator A5037865959 @default.
• W4380792789 creator A5048738944 @default.
• W4380792789 creator A5070796563 @default.
• W4380792789 creator A5087867525 @default.
• W4380792789 creator A5092177701 @default.
• W4380792789 date "2023-10-01" @default.
• W4380792789 modified "2023-09-30" @default.
• W4380792789 title "Oxidative stress as regulator of neuronal impairment after exposure to hospital effluents in Danio rerio" @default.
• W4380792789 cites W1508162082 @default.
• W4380792789 cites W1557712018 @default.
• W4380792789 cites W1590457525 @default.
• W4380792789 cites W1750690213 @default.
• W4380792789 cites W1965130745 @default.
• W4380792789 cites W1965364425 @default.
• W4380792789 cites W1967534941 @default.
• W4380792789 cites W1971048984 @default.
• W4380792789 cites W1974326643 @default.
• W4380792789 cites W1975466288 @default.
• W4380792789 cites W1977368374 @default.
• W4380792789 cites W1982536530 @default.
• W4380792789 cites W1990504067 @default.
• W4380792789 cites W2015626449 @default.
• W4380792789 cites W2023592432 @default.
• W4380792789 cites W2023723789 @default.
• W4380792789 cites W2060157902 @default.
• W4380792789 cites W2061333433 @default.
• W4380792789 cites W2067461984 @default.
• W4380792789 cites W2085907924 @default.
• W4380792789 cites W2089297960 @default.
• W4380792789 cites W2098497801 @default.
• W4380792789 cites W2106230468 @default.
• W4380792789 cites W2107277218 @default.
• W4380792789 cites W2108995381 @default.
• W4380792789 cites W2134685432 @default.
• W4380792789 cites W2227751224 @default.
• W4380792789 cites W2346607647 @default.
• W4380792789 cites W2536024417 @default.
• W4380792789 cites W2544753069 @default.
• W4380792789 cites W2767106749 @default.
• W4380792789 cites W2768499679 @default.
• W4380792789 cites W2791113187 @default.
• W4380792789 cites W2791561224 @default.
• W4380792789 cites W2884409955 @default.
• W4380792789 cites W2886609143 @default.
• W4380792789 cites W2904621076 @default.
• W4380792789 cites W2982031047 @default.
• W4380792789 cites W2989982111 @default.
• W4380792789 cites W3005112436 @default.
• W4380792789 cites W3019611433 @default.
• W4380792789 cites W3037489043 @default.
• W4380792789 cites W3134567965 @default.
• W4380792789 cites W3158146231 @default.
• W4380792789 cites W3185440698 @default.
• W4380792789 cites W3193465328 @default.
• W4380792789 cites W4210811044 @default.
• W4380792789 cites W4220943710 @default.
• W4380792789 cites W4223602796 @default.
• W4380792789 cites W4248078302 @default.
• W4380792789 cites W4280492097 @default.
• W4380792789 cites W4284897914 @default.
• W4380792789 cites W4289525577 @default.
• W4380792789 cites W4293247451 @default.
• W4380792789 cites W4297504218 @default.
• W4380792789 cites W4308344919 @default.
• W4380792789 cites W4308956804 @default.
• W4380792789 cites W4310946304 @default.
• W4380792789 cites W4313453769 @default.
• W4380792789 doi "https://doi.org/10.1016/j.scitotenv.2023.164906" @default.
• W4380792789 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37327895" @default.
• W4380792789 hasPublicationYear "2023" @default.
• W4380792789 type Work @default.
• W4380792789 citedByCount "1" @default.
• W4380792789 countsByYear W43807927892023 @default.
• W4380792789 crossrefType "journal-article" @default.
• W4380792789 hasAuthorship W4380792789A5032812469 @default.
• W4380792789 hasAuthorship W4380792789A5037865959 @default.
• W4380792789 hasAuthorship W4380792789A5048738944 @default.
• W4380792789 hasAuthorship W4380792789A5070796563 @default.
• W4380792789 hasAuthorship W4380792789A5087867525 @default.
• W4380792789 hasAuthorship W4380792789A5092177701 @default.
• W4380792789 hasConcept C104317684 @default.
• W4380792789 hasConcept C147455438 @default.
• W4380792789 hasConcept C181199279 @default.
• W4380792789 hasConcept C185592680 @default.
• W4380792789 hasConcept C18903297 @default.
• W4380792789 hasConcept C2775838275 @default.
• W4380792789 hasConcept C2776151105 @default.
• W4380792789 hasConcept C2776878037 @default.
• W4380792789 hasConcept C2778004101 @default.
• W4380792789 hasConcept C2778816929 @default.
• W4380792789 hasConcept C2778979269 @default.
• W4380792789 hasConcept C2779059548 @default.
• W4380792789 hasConcept C2780384893 @default.
• W4380792789 hasConcept C33070731 @default.
• W4380792789 hasConcept C39432304 @default.

• next