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- W4380793379 abstract "Introduction: Atrial Fibrillation (AF) is the most common cardiac arrythmia in the world. Structural remodeling, inflammatory pathways and fatty acid dysregulation are believed to play a role in the development of AF. Hypothesis: This study explored different biomarkers in the blood of AF patients and a control population to determine if there was a significant difference between the two groups. Methods: Sandwich ELISA kits were used to quantify the collagen remodeling proteins, various inflammatory biomarkers and liver type fatty acid binding protein (L-FABP) in the clinically diagnosed AF population (n=78) and the control population (n=50). Non-stratified fatty acids (NEFAs) were measured using an enzymatic colorimetric kit from Wako Diagnostics. Statistical analyses were performed using GraphPad Prism. Results: We found significant upregulation in all the biomarkers in the AF cohort was noted in comparison to the control group. The collagen remodeling biomarkers included MMP-1, MMP-2, TIMP-1, TIMP-2, PICP, PINP, PIIICP, PIIINP and ICTP. All the collagen remodeling biomarkers were significantly higher in AF patients compared to the control group. The inflammatory biomarker TNFa was also elevated in AF compared to the control group. The fatty acid dysregulation biomarkers, L-FABP and NEFAs, were elevated in AF patients as well. Spearman correlation analyses yielded significant correlations between L-FABP and TIMP-1 (r=0.47, p<0.001), NEFA and TIMP-2 (r=0.41, p=0.002), NEFA and ICTP (r=0.41, p=0.002), and NEFA and PIIINP (r=0.61, p<0.0001). Conclusions: The elevation of all the collagen remodeling biomarkers indicates that there is an upregulation of collagen degradation and deposition in AF which could be contributing to atrial fibrosis. The higher TNFa levels indicate that inflammation could also play a role in the pathogenesis of AF. Fatty acid dysregulation biomarkers, including L-FABP and NEFAs, were elevated in AF patients reinforcing the hypothesis that excess fatty acids could also be contributing to atrial fibrosis and epicardial adipose tissue formation." @default.
- W4380793379 created "2023-06-16" @default.
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- W4380793379 date "2022-11-08" @default.
- W4380793379 modified "2023-09-26" @default.
- W4380793379 title "Abstract 10655: Collagen Remodeling, Inflammatory Biomarkers and Fatty Acid Regulation in Understanding the Molecular Pathogenesis of Atrial Fibrillation" @default.
- W4380793379 doi "https://doi.org/10.1161/circ.146.suppl_1.10655" @default.
- W4380793379 hasPublicationYear "2022" @default.
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