Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380794058> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W4380794058 abstract "Introduction: Social determinants of health (SDOH) are key for the identification of populations at increased risk of developing cardiovascular risk factors (RFs) and ASCVD. In contrast, whether at the individual level SDOH improve current ASCVD risk prediction paradigms beyond traditional RFs and CAC, is unknown. Also, while CAC predicts outcomes across a wide range of risk profiles, its performance across groups with increasing levels of social vulnerability has not been evaluated. Methods: MESA is a prospective study of US adults free of clinical ASCVD at baseline. We developed an SDOH index inclusive of 14 determinants from 5 domains. The index ranged 0-1 and was divided into quartiles, with higher ones representing worse SDOH. Cox regression was used to evaluate the adjusted associations between CAC, SDOH, their interplay, and ASCVD events; and C-statistics were used to assess improvement in risk discrimination for prediction of all/hard events with CAC, SDOH, and both. Results: We included 6,479 MESA participants (50% with CAC=0, 24% CAC>100). The incidence of hard ASCVD events was higher for increasing CAC scores across all SDOH quartiles ( Figure Panel A ). The lowest incidence was noted in those with CAC=0 and favorable SDOH (2/1000 person-ys) and highest in those with CAC>100 and most unfavorable SDOH (20.6/1000 person-ys). CAC improved the discriminatory ability of prediction models, while improvements with SDOH were smaller and were none on top of CAC ( Panel B ). Results were consistent in analyses that evaluated education and income as SDOH exposures. Conclusion: CAC stratifies ASCVD risk across the spectrum of social vulnerability and can guide personalized risk management also among most socially vulnerable populations. In contrast, SDOH fail to improve risk prediction beyond traditional RFs and CAC. Our results provide further support to current ASCVD risk assessment paradigms in the US, and suggest that SDOH have a limited role in this specific setting." @default.
- W4380794058 created "2023-06-16" @default.
- W4380794058 creator A5008531984 @default.
- W4380794058 creator A5027233990 @default.
- W4380794058 creator A5041444092 @default.
- W4380794058 creator A5045437559 @default.
- W4380794058 creator A5065372811 @default.
- W4380794058 creator A5065716655 @default.
- W4380794058 creator A5069024811 @default.
- W4380794058 creator A5072663918 @default.
- W4380794058 creator A5079665496 @default.
- W4380794058 date "2022-11-08" @default.
- W4380794058 modified "2023-10-16" @default.
- W4380794058 title "Abstract 12118: Social Disadvantage, Coronary Artery Calcium, and Their Interplay, in the Prediction of Atherosclerotic Cardiovascular Disease Events: The Multi-Ethnic Study of Atherosclerosis" @default.
- W4380794058 doi "https://doi.org/10.1161/circ.146.suppl_1.12118" @default.
- W4380794058 hasPublicationYear "2022" @default.
- W4380794058 type Work @default.
- W4380794058 citedByCount "0" @default.
- W4380794058 crossrefType "journal-article" @default.
- W4380794058 hasAuthorship W4380794058A5008531984 @default.
- W4380794058 hasAuthorship W4380794058A5027233990 @default.
- W4380794058 hasAuthorship W4380794058A5041444092 @default.
- W4380794058 hasAuthorship W4380794058A5045437559 @default.
- W4380794058 hasAuthorship W4380794058A5065372811 @default.
- W4380794058 hasAuthorship W4380794058A5065716655 @default.
- W4380794058 hasAuthorship W4380794058A5069024811 @default.
- W4380794058 hasAuthorship W4380794058A5072663918 @default.
- W4380794058 hasAuthorship W4380794058A5079665496 @default.
- W4380794058 hasConcept C120665830 @default.
- W4380794058 hasConcept C121332964 @default.
- W4380794058 hasConcept C126322002 @default.
- W4380794058 hasConcept C138816342 @default.
- W4380794058 hasConcept C142724271 @default.
- W4380794058 hasConcept C144024400 @default.
- W4380794058 hasConcept C149923435 @default.
- W4380794058 hasConcept C164705383 @default.
- W4380794058 hasConcept C188816634 @default.
- W4380794058 hasConcept C44249647 @default.
- W4380794058 hasConcept C61511704 @default.
- W4380794058 hasConcept C68443243 @default.
- W4380794058 hasConcept C71924100 @default.
- W4380794058 hasConcept C74909509 @default.
- W4380794058 hasConcept C78491826 @default.
- W4380794058 hasConceptScore W4380794058C120665830 @default.
- W4380794058 hasConceptScore W4380794058C121332964 @default.
- W4380794058 hasConceptScore W4380794058C126322002 @default.
- W4380794058 hasConceptScore W4380794058C138816342 @default.
- W4380794058 hasConceptScore W4380794058C142724271 @default.
- W4380794058 hasConceptScore W4380794058C144024400 @default.
- W4380794058 hasConceptScore W4380794058C149923435 @default.
- W4380794058 hasConceptScore W4380794058C164705383 @default.
- W4380794058 hasConceptScore W4380794058C188816634 @default.
- W4380794058 hasConceptScore W4380794058C44249647 @default.
- W4380794058 hasConceptScore W4380794058C61511704 @default.
- W4380794058 hasConceptScore W4380794058C68443243 @default.
- W4380794058 hasConceptScore W4380794058C71924100 @default.
- W4380794058 hasConceptScore W4380794058C74909509 @default.
- W4380794058 hasConceptScore W4380794058C78491826 @default.
- W4380794058 hasIssue "Suppl_1" @default.
- W4380794058 hasLocation W43807940581 @default.
- W4380794058 hasOpenAccess W4380794058 @default.
- W4380794058 hasPrimaryLocation W43807940581 @default.
- W4380794058 hasRelatedWork W1970383787 @default.
- W4380794058 hasRelatedWork W2017484853 @default.
- W4380794058 hasRelatedWork W2275480158 @default.
- W4380794058 hasRelatedWork W2323044380 @default.
- W4380794058 hasRelatedWork W2409957712 @default.
- W4380794058 hasRelatedWork W2937457496 @default.
- W4380794058 hasRelatedWork W3095306390 @default.
- W4380794058 hasRelatedWork W4238089809 @default.
- W4380794058 hasRelatedWork W4241346791 @default.
- W4380794058 hasRelatedWork W4298139537 @default.
- W4380794058 hasVolume "146" @default.
- W4380794058 isParatext "false" @default.
- W4380794058 isRetracted "false" @default.
- W4380794058 workType "article" @default.