Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380795133> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W4380795133 abstract "Background: The aim of this study was to analyze the effect of evolocumab on vascular function and structure in patients with cardiovascular disease. Methods: This was a prospective, double-blinded, randomized, controlled study (NCT03626831) including patients with cardiovascular disease and treated with statins. Patients were consecutively randomized (1:1) to either evolocumab treatment (420mg was administrated twice during the study) or placebo. All patients underwent vascular examination at baseline, and after 1, 4 and 8 weeks of treatment by the SphygmoCor XCEL System (pulse wave analysis) and the UNEX EF 18G system (endothelial function). Endothelial function parameter such as flow-mediated vasodilation (FMD), low flow-mediated vasoconstriction (L-FMC) and vasoactive range (VAR) were measured. Moreover, pulse wave analysis parameters such as central systolic pressure, central pulse pressure, augmentation index, pulse wave velocity were measured. Results: 103 patients with a mean age of 66.2 (±7.7) years and a mean LDL-cholesterol of 98.2 (±19.1) mg/dl completed the study. LDL-cholesterol decreased significantly already after 1 week of treatment with evolocumab compared to baseline (-47.4 (±13.1) mg/dl). Endothelial function parameter (VAR) increased after 8 weeks of treatment with evolocumab compared to baseline (p=0.034), whereas there was no significant change at 1 and 4 weeks after treatment. Moreover, an improvement in VAR from baseline at week 8 was found with evolocumab compared to placebo (p=0.045). No change in the pulse wave analysis parameters were found with treatment. In a subgroup analysis, in patients with age ≤67 years, lower systolic blood pressure (≤125 mmHg) or higher baseline LDL-cholesterol (>95 mg/dl), significant evolocumab treatment effect was found in VAR improvement (p=0.006, p=0.049 and p=0.042, respectively) from baseline at week 8. Conclusion: Our data indicate that endothelial function could be improved with evolocumab treatment in high-risk patients with preexisting cardiovascular disease and on statin therapy. Our results contribute to the mechanistic explanation why lower incidence of the cardiovascular composite endpoint has been demonstrated in the FOURIER study." @default.
- W4380795133 created "2023-06-16" @default.
- W4380795133 creator A5005548324 @default.
- W4380795133 creator A5007242956 @default.
- W4380795133 creator A5037731520 @default.
- W4380795133 creator A5045274623 @default.
- W4380795133 creator A5048539897 @default.
- W4380795133 creator A5049235067 @default.
- W4380795133 creator A5066875122 @default.
- W4380795133 creator A5072552734 @default.
- W4380795133 creator A5075183492 @default.
- W4380795133 creator A5091399157 @default.
- W4380795133 date "2022-11-08" @default.
- W4380795133 modified "2023-09-24" @default.
- W4380795133 title "Abstract 13958: Evolocumab Alters Vascular Function in Patients With Cardiovascular Disease" @default.
- W4380795133 doi "https://doi.org/10.1161/circ.146.suppl_1.13958" @default.
- W4380795133 hasPublicationYear "2022" @default.
- W4380795133 type Work @default.
- W4380795133 citedByCount "0" @default.
- W4380795133 crossrefType "journal-article" @default.
- W4380795133 hasAuthorship W4380795133A5005548324 @default.
- W4380795133 hasAuthorship W4380795133A5007242956 @default.
- W4380795133 hasAuthorship W4380795133A5037731520 @default.
- W4380795133 hasAuthorship W4380795133A5045274623 @default.
- W4380795133 hasAuthorship W4380795133A5048539897 @default.
- W4380795133 hasAuthorship W4380795133A5049235067 @default.
- W4380795133 hasAuthorship W4380795133A5066875122 @default.
- W4380795133 hasAuthorship W4380795133A5072552734 @default.
- W4380795133 hasAuthorship W4380795133A5075183492 @default.
- W4380795133 hasAuthorship W4380795133A5091399157 @default.
- W4380795133 hasConcept C120770815 @default.
- W4380795133 hasConcept C126322002 @default.
- W4380795133 hasConcept C142724271 @default.
- W4380795133 hasConcept C164705383 @default.
- W4380795133 hasConcept C17140001 @default.
- W4380795133 hasConcept C204787440 @default.
- W4380795133 hasConcept C27081682 @default.
- W4380795133 hasConcept C2778114629 @default.
- W4380795133 hasConcept C2778163477 @default.
- W4380795133 hasConcept C2778319312 @default.
- W4380795133 hasConcept C2780072125 @default.
- W4380795133 hasConcept C2780745583 @default.
- W4380795133 hasConcept C2780972559 @default.
- W4380795133 hasConcept C2908916285 @default.
- W4380795133 hasConcept C71924100 @default.
- W4380795133 hasConcept C84393581 @default.
- W4380795133 hasConceptScore W4380795133C120770815 @default.
- W4380795133 hasConceptScore W4380795133C126322002 @default.
- W4380795133 hasConceptScore W4380795133C142724271 @default.
- W4380795133 hasConceptScore W4380795133C164705383 @default.
- W4380795133 hasConceptScore W4380795133C17140001 @default.
- W4380795133 hasConceptScore W4380795133C204787440 @default.
- W4380795133 hasConceptScore W4380795133C27081682 @default.
- W4380795133 hasConceptScore W4380795133C2778114629 @default.
- W4380795133 hasConceptScore W4380795133C2778163477 @default.
- W4380795133 hasConceptScore W4380795133C2778319312 @default.
- W4380795133 hasConceptScore W4380795133C2780072125 @default.
- W4380795133 hasConceptScore W4380795133C2780745583 @default.
- W4380795133 hasConceptScore W4380795133C2780972559 @default.
- W4380795133 hasConceptScore W4380795133C2908916285 @default.
- W4380795133 hasConceptScore W4380795133C71924100 @default.
- W4380795133 hasConceptScore W4380795133C84393581 @default.
- W4380795133 hasIssue "Suppl_1" @default.
- W4380795133 hasLocation W43807951331 @default.
- W4380795133 hasOpenAccess W4380795133 @default.
- W4380795133 hasPrimaryLocation W43807951331 @default.
- W4380795133 hasRelatedWork W1966324100 @default.
- W4380795133 hasRelatedWork W2097766117 @default.
- W4380795133 hasRelatedWork W2105530733 @default.
- W4380795133 hasRelatedWork W2159094171 @default.
- W4380795133 hasRelatedWork W2313323323 @default.
- W4380795133 hasRelatedWork W2556437978 @default.
- W4380795133 hasRelatedWork W2619136441 @default.
- W4380795133 hasRelatedWork W3189130124 @default.
- W4380795133 hasRelatedWork W4380795133 @default.
- W4380795133 hasRelatedWork W48174363 @default.
- W4380795133 hasVolume "146" @default.
- W4380795133 isParatext "false" @default.
- W4380795133 isRetracted "false" @default.
- W4380795133 workType "article" @default.