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- W43808524 abstract "The use of in vivo imaging technologies in small animal models of hematopoietic stem cell transplantation (HSCT) has greatly improved our understanding of graft-versus-host disease (GVHD) and the graft-versus-leukemia (GVL) effect. Although optical imaging technologies (i.e. bioluminescence and fluorescence imaging) are seldom used in a clinical setting, they are usually the imaging modality of choice for small animal studies due to their relatively low cost and simplicity. However, other technologies, such as positron emission tomography (PET), single-photon emission computer tomography (SPECT) and magnetic resonance imaging (MRI) have been taken from the clinic and adapted for use in small animals. Through the use of these technologies, we now know that GVHD occurs in two discrete phases: an initiation phase where T cells infiltrate secondary lymphoid organs, become activated and begin to proliferate, followed by an effector phase where the T cells migrate to and inflict damage on target tissues. How GVHD and GVL are influenced by various receptor/ligand interactions, chemokines and other molecules, which can affect activation, migration and invasion of tissues, is under active investigation. Furthermore, the efficacies of various immunosuppressive therapies, including receptor/ligand interaction disruption and cellular therapy, have been evaluated in vivo and in real time." @default.
- W43808524 created "2016-06-24" @default.
- W43808524 creator A5005492422 @default.
- W43808524 creator A5068222154 @default.
- W43808524 date "2013-01-01" @default.
- W43808524 modified "2023-09-26" @default.
- W43808524 title "In vivo imaging of graft-versus-host disease and graft-versus-leukemia" @default.
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