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• W4380853844 abstract "Abstract Background Breast cancer is the most commonly detected cancer and one of the leading causes of cancer mortality. Emerging evidence supports that aberrant expression of lncRNAs is correlated with tumor progression and various aspects of tumor development. Aim This study aimed to evaluate the expression pattern of LINC01116 in breast cancer tissues and investigate the impact of LINC01116 on patients' survival. Methods and Results Microarray and qRT‐PCR data analysis were performed, and the KM‐plotter database was used in this study. In addition, the gain of function approach was performed to examine the effect of LINC01116 on breast cancer cells in‐vitro. The results exhibited that LINC01116 is meaningfully upregulated in the ER+ tumor specimens compared to the ER– ones. Also, relative to normal tissues, the expression of LINC01116 in ER+ and ER– tumor tissues significantly increased and decreased, respectively. ROC curve analysis revealed the power of LINC01116 in distinguishing ER+ from ER– samples. Additionally, the Kaplan‐Meier survival analysis showed that the LINC01116 expression positively correlates with survival probability in all as well as ER+ patients. However, this correlation was negative in ER– patients. Furthermore, our results showed that the overexpression of LINC01116 induces TGF‐β signaling in ER– cells (MDA‐MB‐231), and microarray data analysis revealed that LINC01116 is significantly upregulated in 17β‐Estradiol treated MCF7 cells. Conclusion In conclusion, our results suggest that LINC01116 can be a potential biomarker in distinguishing ER+ and ER– tissues and has different effects on patients' survival based on ER status by affecting TGF‐β and ER signaling." @default.
• W4380853844 created "2023-06-16" @default.
• W4380853844 creator A5017566328 @default.
• W4380853844 creator A5037724024 @default.
• W4380853844 creator A5040915789 @default.
• W4380853844 creator A5090485237 @default.
• W4380853844 creator A5092179629 @default.
• W4380853844 date "2023-06-15" @default.
• W4380853844 modified "2023-10-17" @default.
• W4380853844 title "<scp><i>LINC01116</i></scp> affects patient survival differently and is dissimilarly expressed in <scp>ER</scp>+ and <scp>ER</scp>− breast cancer samples" @default.
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• W4380853844 doi "https://doi.org/10.1002/cnr2.1848" @default.
• W4380853844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37321964" @default.
• W4380853844 hasPublicationYear "2023" @default.
• W4380853844 type Work @default.
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• W4380853844 hasAuthorship W4380853844A5017566328 @default.
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• W4380853844 hasAuthorship W4380853844A5040915789 @default.

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