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- W4380853846 endingPage "889" @default.
- W4380853846 startingPage "874" @default.
- W4380853846 abstract "Recombination is thought to be a mechanism that facilitates cross-species transmission in coronaviruses, thus acting as a driver of coronavirus spillover and emergence. Despite its significance, the mechanism of recombination is poorly understood, limiting our potential to estimate the risk of novel recombinant coronaviruses emerging in the future. As a tool for understanding recombination, here, we outline a framework of the recombination pathway for coronaviruses. We review existing literature on coronavirus recombination, including comparisons of naturally observed recombinant genomes as well as in vitro experiments, and place the findings into the recombination pathway framework. We highlight gaps in our understanding of coronavirus recombination illustrated by the framework and outline how further experimental research is critical for disentangling the molecular mechanism of recombination from external environmental pressures. Finally, we describe how an increased understanding of the mechanism of recombination can inform pandemic predictive intelligence, with a retrospective emphasis on SARS-CoV-2." @default.
- W4380853846 created "2023-06-16" @default.
- W4380853846 creator A5008121885 @default.
- W4380853846 creator A5025196559 @default.
- W4380853846 creator A5026413737 @default.
- W4380853846 creator A5074334713 @default.
- W4380853846 creator A5090693104 @default.
- W4380853846 creator A5092179630 @default.
- W4380853846 date "2023-06-01" @default.
- W4380853846 modified "2023-10-01" @default.
- W4380853846 title "The coronavirus recombination pathway" @default.
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