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• W4380853902 endingPage "134" @default.
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• W4380853902 abstract "Immunotherapy has revolutionized the treatment of dozens of cancers and became a standard of care for some tumor types. However, the majority of patients do not benefit from current immunotherapeutics and many develop severe toxicities. Therefore, the identification of biomarkers to classify patients as likely responders or non-responders to immunotherapy is a timely task. Here, we test ultrasound imaging markers of tumor stiffness and perfusion. Ultrasound imaging is non-invasive and clinically available and can be used both for stiffness and perfusion evaluation. In this study, we employed syngeneic orthotopic models of two breast cancers, a fibrosarcoma and a melanoma, to demonstrate that ultrasound-derived measures of tumor stiffness and perfusion (i.e., blood volume) correlate with the efficacy of immune checkpoint inhibition (ICI) in terms of changes in primary tumor volume. To modulate tumor stiffness and perfusion and thus, get a range of therapeutic outcomes, we employed the mechanotherapeutic tranilast. Mechanotherapeutics combined with ICI are advancing through clinical trials, but biomarkers of response have not been tested until now. We found the existence of linear correlations between tumor stiffness and perfusion imaging biomarkers as well as strong linear correlations between the stiffness and perfusion markers with ICI efficacy on primary tumor growth rates. Our findings set the basis for ultrasound biomarkers predictive of ICI therapy in combination with mechanotherapeutics. STATEMENT OF SIGNIFICANCE: Hypothesis: Monitoring Tumor Microenvironment (TME) mechanical abnormalities can predict the efficacy of immune checkpoint inhibition and provide biomarkers predictive of response. Tumor stiffening and solid stress elevation are hallmarks of tumor patho-physiology in desmoplastic tumors. They induce hypo-perfusion and hypoxia by compressing tumor vessels, posing major barriers to immunotherapy. Mechanotherapeutics is a new class of drugs that target the TME to reduce stiffness and improve perfusion and oxygenation. In this study, we show that measures of stiffness and perfusion derived from ultrasound shear wave elastography and contrast enhanced ultrasound can provide biomarkers of tumor response." @default.
• W4380853902 created "2023-06-16" @default.
• W4380853902 creator A5003082907 @default.
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• W4380853902 date "2023-09-01" @default.
• W4380853902 modified "2023-10-15" @default.
• W4380853902 title "Ultrasound stiffness and perfusion markers correlate with tumor volume responses to immunotherapy" @default.
• W4380853902 cites W1735245928 @default.
• W4380853902 cites W1964128680 @default.
• W4380853902 cites W1968583232 @default.
• W4380853902 cites W1969823451 @default.
• W4380853902 cites W1972135632 @default.
• W4380853902 cites W1998266575 @default.
• W4380853902 cites W1998885723 @default.
• W4380853902 cites W2019607817 @default.
• W4380853902 cites W2022540958 @default.
• W4380853902 cites W2024903578 @default.
• W4380853902 cites W2037342985 @default.
• W4380853902 cites W2060469376 @default.
• W4380853902 cites W2094785364 @default.
• W4380853902 cites W2096322385 @default.
• W4380853902 cites W2108984461 @default.
• W4380853902 cites W2137816700 @default.
• W4380853902 cites W2138378181 @default.
• W4380853902 cites W2140741923 @default.
• W4380853902 cites W2142644858 @default.
• W4380853902 cites W2146037312 @default.
• W4380853902 cites W2149360266 @default.
• W4380853902 cites W2169083371 @default.
• W4380853902 cites W2171157655 @default.
• W4380853902 cites W2177405394 @default.
• W4380853902 cites W2257974207 @default.
• W4380853902 cites W2265285917 @default.
• W4380853902 cites W2328171087 @default.
• W4380853902 cites W2345662229 @default.
• W4380853902 cites W2415557067 @default.
• W4380853902 cites W2473218705 @default.
• W4380853902 cites W2513294073 @default.
• W4380853902 cites W2536034592 @default.
• W4380853902 cites W2571012263 @default.
• W4380853902 cites W2583706707 @default.
• W4380853902 cites W2589726211 @default.
• W4380853902 cites W2606343471 @default.
• W4380853902 cites W2754451073 @default.
• W4380853902 cites W2769133871 @default.
• W4380853902 cites W2785803176 @default.
• W4380853902 cites W2790651932 @default.
• W4380853902 cites W2791636384 @default.
• W4380853902 cites W2793350103 @default.
• W4380853902 cites W2793869682 @default.
• W4380853902 cites W2800799386 @default.
• W4380853902 cites W2803839803 @default.
• W4380853902 cites W2902771169 @default.
• W4380853902 cites W2903904910 @default.
• W4380853902 cites W2906371753 @default.
• W4380853902 cites W2909932177 @default.
• W4380853902 cites W2913373289 @default.
• W4380853902 cites W2943362985 @default.
• W4380853902 cites W2947955936 @default.
• W4380853902 cites W2949123718 @default.
• W4380853902 cites W2960244241 @default.
• W4380853902 cites W2989757152 @default.
• W4380853902 cites W2992332278 @default.
• W4380853902 cites W2996744075 @default.
• W4380853902 cites W3003714437 @default.
• W4380853902 cites W3003951026 @default.
• W4380853902 cites W3004769637 @default.
• W4380853902 cites W3009881397 @default.
• W4380853902 cites W3040972323 @default.
• W4380853902 cites W3046888591 @default.
• W4380853902 cites W3112322911 @default.
• W4380853902 cites W3156328900 @default.
• W4380853902 cites W4200438846 @default.
• W4380853902 cites W4206697973 @default.
• W4380853902 cites W4220783622 @default.
• W4380853902 cites W4280522200 @default.
• W4380853902 cites W4281768621 @default.
• W4380853902 cites W4283070688 @default.
• W4380853902 cites W4285678580 @default.
• W4380853902 cites W4305070937 @default.
• W4380853902 cites W4309746155 @default.
• W4380853902 cites W4313278116 @default.
• W4380853902 doi "https://doi.org/10.1016/j.actbio.2023.06.007" @default.
• W4380853902 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37321529" @default.
• W4380853902 hasPublicationYear "2023" @default.
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