Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380854057> ?p ?o ?g. }
- W4380854057 endingPage "102691" @default.
- W4380854057 startingPage "102691" @default.
- W4380854057 abstract "Gene therapy is a promising approach for treating genetic disorders by delivering therapeutic genes to replace or correct malfunctioning genes. However, the introduced gene therapy vector can trigger an immune response, leading to reduced efficacy and potential harm to the patient. To improve the efficiency and safety of gene therapy, preventing the immune response to the vector is crucial. This can be achieved through the use of immunosuppressive drugs, vector engineering to evade the immune system, or delivery methods that bypass the immune system altogether. By reducing the immune response, gene therapy can deliver therapeutic genes more effectively and potentially cure genetic diseases. In this study, a novel molecular imprinting technique, combined with mass-spectrometry and bioinformatics, was used to identify four antigen-binding fragments (Fab) sequences of Adeno-Associated Virus (AAV) - neutralising antibodies capable of binding to AAV. The identified Fab peptides were shown to prevent AAV8's binding to antibodies, demonstrating their potential to improve gene therapy efficiency by preventing the immune response." @default.
- W4380854057 created "2023-06-16" @default.
- W4380854057 creator A5001362474 @default.
- W4380854057 creator A5004799674 @default.
- W4380854057 creator A5010594818 @default.
- W4380854057 creator A5019075982 @default.
- W4380854057 creator A5032419101 @default.
- W4380854057 creator A5035377481 @default.
- W4380854057 creator A5038581690 @default.
- W4380854057 creator A5049298836 @default.
- W4380854057 creator A5067262313 @default.
- W4380854057 creator A5080778019 @default.
- W4380854057 date "2023-08-01" @default.
- W4380854057 modified "2023-10-16" @default.
- W4380854057 title "Analysis of Adeno-Associated Virus Serotype 8 (AAV8)-antibody complexes using epitope mapping by molecular imprinting leads to the identification of Fab peptides that potentially evade AAV8 neutralisation" @default.
- W4380854057 cites W149497181 @default.
- W4380854057 cites W1822742328 @default.
- W4380854057 cites W1971284136 @default.
- W4380854057 cites W1973658117 @default.
- W4380854057 cites W1976329054 @default.
- W4380854057 cites W1987134040 @default.
- W4380854057 cites W1994640759 @default.
- W4380854057 cites W2001738143 @default.
- W4380854057 cites W2010344791 @default.
- W4380854057 cites W2024568218 @default.
- W4380854057 cites W2033689077 @default.
- W4380854057 cites W2044050006 @default.
- W4380854057 cites W2052219470 @default.
- W4380854057 cites W2060149378 @default.
- W4380854057 cites W2060637142 @default.
- W4380854057 cites W2070754430 @default.
- W4380854057 cites W2072383478 @default.
- W4380854057 cites W2082025265 @default.
- W4380854057 cites W2082549237 @default.
- W4380854057 cites W2088212973 @default.
- W4380854057 cites W2090661761 @default.
- W4380854057 cites W2098274109 @default.
- W4380854057 cites W2099345438 @default.
- W4380854057 cites W2102111681 @default.
- W4380854057 cites W2103285488 @default.
- W4380854057 cites W2113444875 @default.
- W4380854057 cites W2130479394 @default.
- W4380854057 cites W2132629607 @default.
- W4380854057 cites W2133171074 @default.
- W4380854057 cites W2133251787 @default.
- W4380854057 cites W2153140538 @default.
- W4380854057 cites W2170205772 @default.
- W4380854057 cites W2170490863 @default.
- W4380854057 cites W2170614901 @default.
- W4380854057 cites W2171988116 @default.
- W4380854057 cites W2266837556 @default.
- W4380854057 cites W2411847918 @default.
- W4380854057 cites W2595176717 @default.
- W4380854057 cites W2618545704 @default.
- W4380854057 cites W2774511679 @default.
- W4380854057 cites W2793858050 @default.
- W4380854057 cites W2886127363 @default.
- W4380854057 cites W2897417813 @default.
- W4380854057 cites W2913212173 @default.
- W4380854057 cites W2945235170 @default.
- W4380854057 cites W2947082286 @default.
- W4380854057 cites W2964149073 @default.
- W4380854057 cites W2966032765 @default.
- W4380854057 cites W3004887743 @default.
- W4380854057 cites W3031321424 @default.
- W4380854057 cites W3096808977 @default.
- W4380854057 cites W3130546939 @default.
- W4380854057 cites W3144545288 @default.
- W4380854057 cites W3182677245 @default.
- W4380854057 cites W3196291785 @default.
- W4380854057 cites W3202181895 @default.
- W4380854057 cites W4206495542 @default.
- W4380854057 cites W4221021438 @default.
- W4380854057 cites W4283725175 @default.
- W4380854057 cites W4283778388 @default.
- W4380854057 cites W4312094148 @default.
- W4380854057 doi "https://doi.org/10.1016/j.nano.2023.102691" @default.
- W4380854057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37329939" @default.
- W4380854057 hasPublicationYear "2023" @default.
- W4380854057 type Work @default.
- W4380854057 citedByCount "0" @default.
- W4380854057 crossrefType "journal-article" @default.
- W4380854057 hasAuthorship W4380854057A5001362474 @default.
- W4380854057 hasAuthorship W4380854057A5004799674 @default.
- W4380854057 hasAuthorship W4380854057A5010594818 @default.
- W4380854057 hasAuthorship W4380854057A5019075982 @default.
- W4380854057 hasAuthorship W4380854057A5032419101 @default.
- W4380854057 hasAuthorship W4380854057A5035377481 @default.
- W4380854057 hasAuthorship W4380854057A5038581690 @default.
- W4380854057 hasAuthorship W4380854057A5049298836 @default.
- W4380854057 hasAuthorship W4380854057A5067262313 @default.
- W4380854057 hasAuthorship W4380854057A5080778019 @default.
- W4380854057 hasBestOaLocation W43808540571 @default.
- W4380854057 hasConcept C104317684 @default.
- W4380854057 hasConcept C111599444 @default.
- W4380854057 hasConcept C135983454 @default.
- W4380854057 hasConcept C147483822 @default.
- W4380854057 hasConcept C159047783 @default.