FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380854573> ?p ?o ?g. }

• W4380854573 endingPage "187" @default.
• W4380854573 startingPage "175" @default.
• W4380854573 abstract "Mitochondria-targeted coenzyme Q10 (Mito-ubiquinone, Mito-quinone mesylate, or MitoQ) was shown to be an effective antimetastatic drug in patients with triple-negative breast cancer. MitoQ, sold as a nutritional supplement, prevents breast cancer recurrence. It potently inhibited tumor growth and tumor cell proliferation in preclinical xenograft models and in vitro breast cancer cells. The proposed mechanism of action involves the inhibition of reactive oxygen species by MitoQ via a redox-cycling mechanism between the oxidized form, MitoQ, and the fully reduced form, MitoQH2 (also called Mito-ubiquinol). To fully corroborate this antioxidant mechanism, we substituted the hydroquinone group (-OH) with the methoxy group (-OCH3). Unlike MitoQ, the modified form, dimethoxy MitoQ (DM-MitoQ), lacks redox-cycling between the quinone and hydroquinone forms. DM-MitoQ was not converted to MitoQ in MDA-MB-231 cells. We tested the antiproliferative effects of both MitoQ and DM-MitoQ in human breast cancer (MDA-MB-231), brain-homing cancer (MDA-MB-231BR), and glioma (U87MG) cells. Surprisingly, DM-MitoQ was slightly more potent than MitoQ (IC50 = 0.26 μM versus 0.38 μM) at inhibiting proliferation of these cells. Both MitoQ and DM-MitoQ potently inhibited mitochondrial complex I-dependent oxygen consumption (IC50 = 0.52 μM and 0.17 μM, respectively). This study also suggests that DM-MitoQ, which is a more hydrophobic analog of MitoQ (logP: 10.1 and 8.7) devoid of antioxidant function and reactive oxygen species scavenging ability, can inhibit cancer cell proliferation. We conclude that inhibition of mitochondrial oxidative phosphorylation by MitoQ is responsible for inhibition of breast cancer and glioma proliferation and metastasis. Blunting the antioxidant effect using the redox-crippled DM-MitoQ can serve as a useful negative control in corroborating the involvement of free radical-mediated processes (e.g., ferroptosis, protein oxidation/nitration) using MitoQ in other oxidative pathologies." @default.
• W4380854573 created "2023-06-16" @default.
• W4380854573 creator A5002103444 @default.
• W4380854573 creator A5011165903 @default.
• W4380854573 creator A5015448880 @default.
• W4380854573 creator A5053435940 @default.
• W4380854573 date "2023-08-01" @default.
• W4380854573 modified "2023-09-30" @default.
• W4380854573 title "Redox-crippled MitoQ potently inhibits breast cancer and glioma cell proliferation: A negative control for verifying the antioxidant mechanism of MitoQ in cancer and other oxidative pathologies" @default.
• W4380854573 cites W1512824421 @default.
• W4380854573 cites W1623473717 @default.
• W4380854573 cites W1901021723 @default.
• W4380854573 cites W1969628253 @default.
• W4380854573 cites W1970908751 @default.
• W4380854573 cites W1971202292 @default.
• W4380854573 cites W1972507229 @default.
• W4380854573 cites W1979840598 @default.
• W4380854573 cites W1982330633 @default.
• W4380854573 cites W1988664434 @default.
• W4380854573 cites W1989224728 @default.
• W4380854573 cites W1990163734 @default.
• W4380854573 cites W1995622255 @default.
• W4380854573 cites W1996885665 @default.
• W4380854573 cites W1997611244 @default.
• W4380854573 cites W2001297765 @default.
• W4380854573 cites W2001565942 @default.
• W4380854573 cites W2002778565 @default.
• W4380854573 cites W2010524294 @default.
• W4380854573 cites W2010716981 @default.
• W4380854573 cites W2017692041 @default.
• W4380854573 cites W2020600203 @default.
• W4380854573 cites W2029103952 @default.
• W4380854573 cites W2038009564 @default.
• W4380854573 cites W2039093830 @default.
• W4380854573 cites W2043429649 @default.
• W4380854573 cites W2046178144 @default.
• W4380854573 cites W2048981098 @default.
• W4380854573 cites W2049285362 @default.
• W4380854573 cites W2057295103 @default.
• W4380854573 cites W2059623168 @default.
• W4380854573 cites W2078265076 @default.
• W4380854573 cites W2094143445 @default.
• W4380854573 cites W2098131661 @default.
• W4380854573 cites W2098227836 @default.
• W4380854573 cites W2107045256 @default.
• W4380854573 cites W2119437574 @default.
• W4380854573 cites W2121393443 @default.
• W4380854573 cites W2123051296 @default.
• W4380854573 cites W2140014506 @default.
• W4380854573 cites W2151001188 @default.
• W4380854573 cites W2160298454 @default.
• W4380854573 cites W2161859769 @default.
• W4380854573 cites W2163447290 @default.
• W4380854573 cites W2164298973 @default.
• W4380854573 cites W2188526507 @default.
• W4380854573 cites W2281758534 @default.
• W4380854573 cites W2403543580 @default.
• W4380854573 cites W2519401768 @default.
• W4380854573 cites W2563510813 @default.
• W4380854573 cites W2582092041 @default.
• W4380854573 cites W2735042627 @default.
• W4380854573 cites W2791235391 @default.
• W4380854573 cites W2885747263 @default.
• W4380854573 cites W2913788177 @default.
• W4380854573 cites W2918054297 @default.
• W4380854573 cites W2945385843 @default.
• W4380854573 cites W2998329505 @default.
• W4380854573 cites W3005142733 @default.
• W4380854573 cites W3017098366 @default.
• W4380854573 cites W3018971322 @default.
• W4380854573 cites W3065157603 @default.
• W4380854573 cites W3085103914 @default.
• W4380854573 cites W3086146444 @default.
• W4380854573 cites W3097126181 @default.
• W4380854573 cites W3097153985 @default.
• W4380854573 cites W3125116731 @default.
• W4380854573 cites W3169630907 @default.
• W4380854573 cites W3185682642 @default.
• W4380854573 cites W3200632075 @default.
• W4380854573 cites W3213224987 @default.
• W4380854573 cites W3217239624 @default.
• W4380854573 cites W4206129181 @default.
• W4380854573 cites W4210746507 @default.
• W4380854573 cites W4220715539 @default.
• W4380854573 cites W4220751331 @default.
• W4380854573 cites W4221107874 @default.
• W4380854573 cites W4283166505 @default.
• W4380854573 cites W4284889683 @default.
• W4380854573 cites W4289638016 @default.
• W4380854573 cites W4303700012 @default.
• W4380854573 cites W4309436616 @default.
• W4380854573 cites W4317499897 @default.
• W4380854573 cites W4317500708 @default.
• W4380854573 cites W4318771331 @default.
• W4380854573 doi "https://doi.org/10.1016/j.freeradbiomed.2023.06.009" @default.
• W4380854573 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37321281" @default.
• W4380854573 hasPublicationYear "2023" @default.
• W4380854573 type Work @default.

• next