FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380870571> ?p ?o ?g. }

• W4380870571 abstract "Spinal cord injury (SCI) in young adults leads to severe sensorimotor disabilities as well as slowing of growth. Systemic pro-inflammatory cytokines are associated with growth failure and muscle wasting. Here we investigated whether intravenous (IV) delivery of small extracellular vesicles (sEVs) derived from human mesenchymal stem/stromal cells (MSC) has therapeutic effects on body growth and motor recovery and can modulate inflammatory cytokines following severe SCI in young adult rats.Contusional SCI rats were randomized into three different treatment groups (human and rat MSC-sEVs and a PBS group) on day 7 post-SCI. Functional motor recovery and body growth were assessed weekly until day 70 post-SCI. Trafficking of sEVs after IV infusions in vivo, the uptake of sEVs in vitro, macrophage phenotype at the lesion and cytokine levels at the lesion, liver and systemic circulation were also evaluated.An IV delivery of both human and rat MSC-sEVs improved functional motor recovery after SCI and restored normal body growth in young adult SCI rats, indicating a broad therapeutic benefit of MSC-sEVs and a lack of species specificity for these effects. Human MSC-sEVs were selectively taken up by M2 macrophages in vivo and in vitro, consistent with our previous observations of rat MSC-sEV uptake. Furthermore, the infusion of human or rat MSC-sEVs resulted in an increase in the proportion of M2 macrophages and a decrease in the production of the pro-inflammatory cytokines tumour necrosis factor-alpha (TNF-α) and interleukin (IL)-6 at the injury site, as well as a reduction in systemic serum levels of TNF-α and IL-6 and an increase in growth hormone receptors and IGF-1 levels in the liver.Both human and rat MSC-sEVs promote the recovery of body growth and motor function after SCI in young adult rats possibly via the cytokine modulation of growth-related hormonal pathways. Thus, MSC-sEVs affect both metabolic and neurological deficits in SCI." @default.
• W4380870571 created "2023-06-17" @default.
• W4380870571 creator A5002181387 @default.
• W4380870571 creator A5048479394 @default.
• W4380870571 creator A5050554151 @default.
• W4380870571 creator A5060562541 @default.
• W4380870571 creator A5092181002 @default.
• W4380870571 date "2023-06-01" @default.
• W4380870571 modified "2023-10-14" @default.
• W4380870571 title "Human mesenchymal stem‐derived extracellular vesicles improve body growth and motor function following severe spinal cord injury in rat" @default.
• W4380870571 cites W1877686344 @default.
• W4380870571 cites W1965495374 @default.
• W4380870571 cites W1975724680 @default.
• W4380870571 cites W1985413489 @default.
• W4380870571 cites W1994791148 @default.
• W4380870571 cites W2006811526 @default.
• W4380870571 cites W2023476837 @default.
• W4380870571 cites W2034199603 @default.
• W4380870571 cites W2038224079 @default.
• W4380870571 cites W2038847295 @default.
• W4380870571 cites W2055883753 @default.
• W4380870571 cites W2065722470 @default.
• W4380870571 cites W2068853602 @default.
• W4380870571 cites W2106457523 @default.
• W4380870571 cites W2108896478 @default.
• W4380870571 cites W2114570899 @default.
• W4380870571 cites W2120685424 @default.
• W4380870571 cites W2204697639 @default.
• W4380870571 cites W2517539167 @default.
• W4380870571 cites W2587052085 @default.
• W4380870571 cites W2782372577 @default.
• W4380870571 cites W2829474003 @default.
• W4380870571 cites W2912953799 @default.
• W4380870571 cites W2933304441 @default.
• W4380870571 cites W2938285000 @default.
• W4380870571 cites W2942732217 @default.
• W4380870571 cites W2959357913 @default.
• W4380870571 cites W3001027940 @default.
• W4380870571 cites W3131874286 @default.
• W4380870571 cites W3196507015 @default.
• W4380870571 cites W3199119690 @default.
• W4380870571 doi "https://doi.org/10.1002/ctm2.1284" @default.
• W4380870571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37323108" @default.
• W4380870571 hasPublicationYear "2023" @default.
• W4380870571 type Work @default.
• W4380870571 citedByCount "0" @default.
• W4380870571 crossrefType "journal-article" @default.
• W4380870571 hasAuthorship W4380870571A5002181387 @default.
• W4380870571 hasAuthorship W4380870571A5048479394 @default.
• W4380870571 hasAuthorship W4380870571A5050554151 @default.
• W4380870571 hasAuthorship W4380870571A5060562541 @default.
• W4380870571 hasAuthorship W4380870571A5092181002 @default.
• W4380870571 hasBestOaLocation W43808705711 @default.
• W4380870571 hasConcept C118552586 @default.
• W4380870571 hasConcept C126322002 @default.
• W4380870571 hasConcept C142724271 @default.
• W4380870571 hasConcept C150903083 @default.
• W4380870571 hasConcept C17991360 @default.
• W4380870571 hasConcept C198826908 @default.
• W4380870571 hasConcept C203014093 @default.
• W4380870571 hasConcept C207001950 @default.
• W4380870571 hasConcept C2776914184 @default.
• W4380870571 hasConcept C2778334475 @default.
• W4380870571 hasConcept C2778690821 @default.
• W4380870571 hasConcept C2779764123 @default.
• W4380870571 hasConcept C2779830541 @default.
• W4380870571 hasConcept C2780775167 @default.
• W4380870571 hasConcept C2781156865 @default.
• W4380870571 hasConcept C71924100 @default.
• W4380870571 hasConcept C86803240 @default.
• W4380870571 hasConcept C98274493 @default.
• W4380870571 hasConceptScore W4380870571C118552586 @default.
• W4380870571 hasConceptScore W4380870571C126322002 @default.
• W4380870571 hasConceptScore W4380870571C142724271 @default.
• W4380870571 hasConceptScore W4380870571C150903083 @default.
• W4380870571 hasConceptScore W4380870571C17991360 @default.
• W4380870571 hasConceptScore W4380870571C198826908 @default.
• W4380870571 hasConceptScore W4380870571C203014093 @default.
• W4380870571 hasConceptScore W4380870571C207001950 @default.
• W4380870571 hasConceptScore W4380870571C2776914184 @default.
• W4380870571 hasConceptScore W4380870571C2778334475 @default.
• W4380870571 hasConceptScore W4380870571C2778690821 @default.
• W4380870571 hasConceptScore W4380870571C2779764123 @default.
• W4380870571 hasConceptScore W4380870571C2779830541 @default.
• W4380870571 hasConceptScore W4380870571C2780775167 @default.
• W4380870571 hasConceptScore W4380870571C2781156865 @default.
• W4380870571 hasConceptScore W4380870571C71924100 @default.
• W4380870571 hasConceptScore W4380870571C86803240 @default.
• W4380870571 hasConceptScore W4380870571C98274493 @default.
• W4380870571 hasFunder F4320332403 @default.
• W4380870571 hasIssue "6" @default.
• W4380870571 hasLocation W43808705711 @default.
• W4380870571 hasLocation W43808705712 @default.
• W4380870571 hasLocation W43808705713 @default.
• W4380870571 hasOpenAccess W4380870571 @default.
• W4380870571 hasPrimaryLocation W43808705711 @default.
• W4380870571 hasRelatedWork W2003440016 @default.
• W4380870571 hasRelatedWork W2005022924 @default.
• W4380870571 hasRelatedWork W2018075260 @default.
• W4380870571 hasRelatedWork W2053108497 @default.

• next