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- W4380871251 abstract "Although metastasis is the leading cause of cancer deaths, it is quite rare at the cellular level. Only a rare subset of cancer cells (~ 1 in 1.5 billion) can complete the entire metastatic cascade: invasion, intravasation, survival in the circulation, extravasation, and colonization (i.e. are metastasis competent). We propose that cells engaging a Polyaneuploid Cancer Cell (PACC) phenotype are metastasis competent. Cells in the PACC state are enlarged, endocycling (i.e. non-dividing) cells with increased genomic content that form in response to stress. Single-cell tracking using time lapse microscopy reveals that PACC state cells have increased motility. Additionally, cells in the PACC state exhibit increased capacity for environment-sensing and directional migration in chemotactic environments, predicting successful invasion. Magnetic Twisting Cytometry and Atomic Force Microscopy reveal that cells in the PACC state display hyper-elastic properties like increased peripheral deformability and maintained peri-nuclear cortical integrity that predict successful intravasation and extravasation. Furthermore, four orthogonal methods reveal that cells in the PACC state have increased expression of vimentin, a hyper-elastic biomolecule known to modulate biomechanical properties and induce mesenchymal-like motility. Taken together, these data indicate that cells in the PACC state have increased metastatic potential and are worthy of further in vivo analysis." @default.
- W4380871251 created "2023-06-17" @default.
- W4380871251 creator A5002629506 @default.
- W4380871251 creator A5006302701 @default.
- W4380871251 creator A5013362793 @default.
- W4380871251 creator A5033299619 @default.
- W4380871251 creator A5049205771 @default.
- W4380871251 creator A5049898092 @default.
- W4380871251 creator A5058937957 @default.
- W4380871251 creator A5087520734 @default.
- W4380871251 creator A5091226344 @default.
- W4380871251 date "2023-06-16" @default.
- W4380871251 modified "2023-10-17" @default.
- W4380871251 title "Cells in the polyaneuploid cancer cell (PACC) state have increased metastatic potential" @default.
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