FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380871570> ?p ?o ?g. }

• W4380871570 endingPage "640" @default.
• W4380871570 startingPage "632" @default.
• W4380871570 abstract "5-Nitrosalicylate 1,2-dioxygenase (5NSDO) is an iron(II)-dependent dioxygenase involved in the aerobic degradation of 5-nitroanthranilic acid by the bacterium Bradyrhizobium sp. It catalyzes the opening of the 5-nitrosalicylate aromatic ring, a key step in the degradation pathway. Besides 5-nitrosalicylate, the enzyme is also active towards 5-chlorosalicylate. The X-ray crystallographic structure of the enzyme was solved at 2.1 Å resolution by molecular replacement using a model from the AI program AlphaFold. The enzyme crystallized in the monoclinic space group P21, with unit-cell parameters a = 50.42, b = 143.17, c = 60.07 Å, β = 107.3°. 5NSDO belongs to the third class of ring-cleaving dioxygenases. Members of this family convert para-diols or hydroxylated aromatic carboxylic acids and belong to the cupin superfamily, which is one of the most functionally diverse protein classes and is named on the basis of a conserved β-barrel fold. 5NSDO is a tetramer composed of four identical subunits, each folded as a monocupin domain. The iron(II) ion in the enzyme active site is coordinated by His96, His98 and His136 and three water molecules with a distorted octahedral geometry. The residues in the active site are poorly conserved compared with other dioxygenases of the third class, such as gentisate 1,2-dioxygenase and salicylate 1,2-dioxygenase. Comparison with these other representatives of the same class and docking of the substrate into the active site of 5NSDO allowed the identification of residues which are crucial for the catalytic mechanism and enzyme selectivity." @default.
• W4380871570 created "2023-06-17" @default.
• W4380871570 creator A5000668552 @default.
• W4380871570 creator A5031417252 @default.
• W4380871570 creator A5073951252 @default.
• W4380871570 date "2023-06-16" @default.
• W4380871570 modified "2023-09-23" @default.
• W4380871570 title "Crystal structure of the monocupin ring-cleaving dioxygenase 5-nitrosalicylate 1,2-dioxygenase from <i>Bradyrhizobium</i> sp." @default.
• W4380871570 cites W1592830109 @default.
• W4380871570 cites W1892158199 @default.
• W4380871570 cites W1963514652 @default.
• W4380871570 cites W1984531703 @default.
• W4380871570 cites W1993922632 @default.
• W4380871570 cites W2000268335 @default.
• W4380871570 cites W2011658408 @default.
• W4380871570 cites W2017139708 @default.
• W4380871570 cites W2020551149 @default.
• W4380871570 cites W2035503835 @default.
• W4380871570 cites W2055117502 @default.
• W4380871570 cites W2057773123 @default.
• W4380871570 cites W2062996884 @default.
• W4380871570 cites W2075562416 @default.
• W4380871570 cites W2078336779 @default.
• W4380871570 cites W2084575458 @default.
• W4380871570 cites W2086747527 @default.
• W4380871570 cites W2123804946 @default.
• W4380871570 cites W2124026197 @default.
• W4380871570 cites W2127874990 @default.
• W4380871570 cites W2128635872 @default.
• W4380871570 cites W2132629607 @default.
• W4380871570 cites W2134967712 @default.
• W4380871570 cites W2140889813 @default.
• W4380871570 cites W2141625051 @default.
• W4380871570 cites W2144998676 @default.
• W4380871570 cites W2146080841 @default.
• W4380871570 cites W2159211495 @default.
• W4380871570 cites W2166180414 @default.
• W4380871570 cites W2166259570 @default.
• W4380871570 cites W2176860051 @default.
• W4380871570 cites W2590103666 @default.
• W4380871570 cites W2973457155 @default.
• W4380871570 cites W3130686756 @default.
• W4380871570 cites W3173575423 @default.
• W4380871570 cites W3177828909 @default.
• W4380871570 cites W3178087467 @default.
• W4380871570 cites W3211795435 @default.
• W4380871570 cites W4226432872 @default.
• W4380871570 cites W4248872320 @default.
• W4380871570 cites W4293247451 @default.
• W4380871570 cites W4378952892 @default.
• W4380871570 cites W641095229 @default.
• W4380871570 doi "https://doi.org/10.1107/s2059798323004199" @default.
• W4380871570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37326584" @default.
• W4380871570 hasPublicationYear "2023" @default.
• W4380871570 type Work @default.
• W4380871570 citedByCount "0" @default.
• W4380871570 crossrefType "journal-article" @default.
• W4380871570 hasAuthorship W4380871570A5000668552 @default.
• W4380871570 hasAuthorship W4380871570A5031417252 @default.
• W4380871570 hasAuthorship W4380871570A5073951252 @default.
• W4380871570 hasBestOaLocation W43808715701 @default.
• W4380871570 hasConcept C181199279 @default.
• W4380871570 hasConcept C185592680 @default.
• W4380871570 hasConcept C2776834422 @default.
• W4380871570 hasConcept C2777166331 @default.
• W4380871570 hasConcept C2778886173 @default.
• W4380871570 hasConcept C2779268744 @default.
• W4380871570 hasConcept C2779856404 @default.
• W4380871570 hasConcept C2780120296 @default.
• W4380871570 hasConcept C2781385570 @default.
• W4380871570 hasConcept C41183919 @default.
• W4380871570 hasConcept C43144210 @default.
• W4380871570 hasConcept C523546767 @default.
• W4380871570 hasConcept C54355233 @default.
• W4380871570 hasConcept C55493867 @default.
• W4380871570 hasConcept C71240020 @default.
• W4380871570 hasConcept C86803240 @default.
• W4380871570 hasConceptScore W4380871570C181199279 @default.
• W4380871570 hasConceptScore W4380871570C185592680 @default.
• W4380871570 hasConceptScore W4380871570C2776834422 @default.
• W4380871570 hasConceptScore W4380871570C2777166331 @default.
• W4380871570 hasConceptScore W4380871570C2778886173 @default.
• W4380871570 hasConceptScore W4380871570C2779268744 @default.
• W4380871570 hasConceptScore W4380871570C2779856404 @default.
• W4380871570 hasConceptScore W4380871570C2780120296 @default.
• W4380871570 hasConceptScore W4380871570C2781385570 @default.
• W4380871570 hasConceptScore W4380871570C41183919 @default.
• W4380871570 hasConceptScore W4380871570C43144210 @default.
• W4380871570 hasConceptScore W4380871570C523546767 @default.
• W4380871570 hasConceptScore W4380871570C54355233 @default.
• W4380871570 hasConceptScore W4380871570C55493867 @default.
• W4380871570 hasConceptScore W4380871570C71240020 @default.
• W4380871570 hasConceptScore W4380871570C86803240 @default.
• W4380871570 hasIssue "7" @default.
• W4380871570 hasLocation W43808715701 @default.
• W4380871570 hasLocation W43808715702 @default.
• W4380871570 hasLocation W43808715703 @default.
• W4380871570 hasOpenAccess W4380871570 @default.

• next