Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380871878> ?p ?o ?g. }
- W4380871878 abstract "Infection with certain cutaneous human papillomaviruses (HPV), in conjunction with chronic ultraviolet (UV) exposure, are the major cofactors of non-melanoma skin cancer (NMSC), the most frequent cancer type worldwide. Cutaneous squamous cell carcinomas (SCCs) as well as tumors in general represent three-dimensional entities determined by both temporal and spatial constraints. Whole tissue proteomics is a straightforward approach to understand tumorigenesis in better detail, but studies focusing on different progression states toward a dedifferentiated SCC phenotype on a spatial level are rare. Here, we applied an innovative proteomic workflow on formalin-fixed, paraffin-embedded (FFPE) epithelial tumors derived from the preclinical animal model Mastomys coucha. This rodent is naturally infected with its genuine cutaneous papillomavirus and closely mimics skin carcinogenesis in the context of cutaneous HPV infections in humans. We deciphered cellular networks by comparing diverse epithelial tissues with respect to their differentiation level and infection status. Our study reveals novel regulatory proteins and pathways associated with virus-induced tumor initiation and progression of SCCs. This approach provides the basis to better comprehend the multistep process of skin carcinogenesis." @default.
- W4380871878 created "2023-06-17" @default.
- W4380871878 creator A5019906909 @default.
- W4380871878 creator A5023165393 @default.
- W4380871878 creator A5023994045 @default.
- W4380871878 creator A5029621847 @default.
- W4380871878 creator A5031234897 @default.
- W4380871878 creator A5052518572 @default.
- W4380871878 creator A5079697881 @default.
- W4380871878 creator A5079862362 @default.
- W4380871878 creator A5083752112 @default.
- W4380871878 creator A5089091347 @default.
- W4380871878 creator A5091854234 @default.
- W4380871878 date "2023-06-01" @default.
- W4380871878 modified "2023-10-01" @default.
- W4380871878 title "Spatial tissue proteomics reveals distinct landscapes of heterogeneity in cutaneous papillomavirus‐induced keratinocyte carcinomas" @default.
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