FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380872018> ?p ?o ?g. }

• W4380872018 abstract "Background: Humans with hypertensive heart disease are more likely to experience heart failure, arrhythmia, myocardial infarction, and sudden death, and it is crucial to treat this condition. Fucoidan (FO) is a natural substance derived from marine algae that has antioxidant and immunomodulatory activities. FO has also been shown to regulate apoptosis. However, whether FO can protect against cardiac hypertrophy is unknown. Methods: We investigated the effect of FO in hypertrophic models in vivo and in vitro. C57BL/6 mice were given an oral gavage of FO (300 mg/kg/day) or PBS (internal control) the day before surgery, followed by a 14-day infusion of Ang II or saline. AC-16 cells were treated with si-USP22 for 4 h and then treated with Ang II (100 nM) for 24 h. Systolic blood pressure (SBP) was recorded, echocardiography was used to assess cardiac function, and pathological changes in heart tissues were assessed by histological staining. Apoptosis levels were detected by TUNEL assays. The mRNA level of genes was assessed by qPCR. Protein expression was detected by immunoblotting. Results: Our data showed that USP22 expression was lowered in Ang II-infused animals and cells, which could promote cardiac dysfunction and remodeling. However, treatment with FO significantly upregulated the expression of USP22 and reduced the incidence of cardiac hypertrophy, fibrosis, inflammation, and oxidative responses. Additionally, FO treatment lowered p53 expression and apoptosis while increasing Sirt 1 and Bcl-2 expression. Conclusion: By reducing the level of Ang II-induced apoptosis through the regulation of USP22/Sirt 1 expression, FO treatment might improve cardiac function. According to this study, FO might be potential targeted approach for treating heart failure." @default.
• W4380872018 created "2023-06-17" @default.
• W4380872018 creator A5030890243 @default.
• W4380872018 creator A5036015350 @default.
• W4380872018 creator A5076412438 @default.
• W4380872018 creator A5077236842 @default.
• W4380872018 creator A5092181295 @default.
• W4380872018 date "2023-05-30" @default.
• W4380872018 modified "2023-09-25" @default.
• W4380872018 title "Fucoidan inhibits apoptosis and improves cardiac remodeling by inhibiting p53 transcriptional activation through USP22/Sirt 1" @default.
• W4380872018 cites W1971676204 @default.
• W4380872018 cites W1984412789 @default.
• W4380872018 cites W2036051377 @default.
• W4380872018 cites W2048458820 @default.
• W4380872018 cites W2055900062 @default.
• W4380872018 cites W2079326579 @default.
• W4380872018 cites W2085748917 @default.
• W4380872018 cites W2092799176 @default.
• W4380872018 cites W2104041255 @default.
• W4380872018 cites W2106462989 @default.
• W4380872018 cites W2147917253 @default.
• W4380872018 cites W2148802014 @default.
• W4380872018 cites W2159804480 @default.
• W4380872018 cites W2332233603 @default.
• W4380872018 cites W23903782 @default.
• W4380872018 cites W2415715899 @default.
• W4380872018 cites W2520280394 @default.
• W4380872018 cites W2791234633 @default.
• W4380872018 cites W2801901575 @default.
• W4380872018 cites W2896271733 @default.
• W4380872018 cites W2901373507 @default.
• W4380872018 cites W2920243595 @default.
• W4380872018 cites W2966794993 @default.
• W4380872018 cites W2969453984 @default.
• W4380872018 cites W2979361360 @default.
• W4380872018 cites W3004830535 @default.
• W4380872018 cites W3026787770 @default.
• W4380872018 cites W3091862062 @default.
• W4380872018 cites W3093834771 @default.
• W4380872018 cites W3214092507 @default.
• W4380872018 cites W4213176041 @default.
• W4380872018 cites W4307372485 @default.
• W4380872018 doi "https://doi.org/10.3389/fphar.2023.1164333" @default.
• W4380872018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37324479" @default.
• W4380872018 hasPublicationYear "2023" @default.
• W4380872018 type Work @default.
• W4380872018 citedByCount "0" @default.
• W4380872018 crossrefType "journal-article" @default.
• W4380872018 hasAuthorship W4380872018A5030890243 @default.
• W4380872018 hasAuthorship W4380872018A5036015350 @default.
• W4380872018 hasAuthorship W4380872018A5076412438 @default.
• W4380872018 hasAuthorship W4380872018A5077236842 @default.
• W4380872018 hasAuthorship W4380872018A5092181295 @default.
• W4380872018 hasBestOaLocation W43808720181 @default.
• W4380872018 hasConcept C100817775 @default.
• W4380872018 hasConcept C104317684 @default.
• W4380872018 hasConcept C126322002 @default.
• W4380872018 hasConcept C127561419 @default.
• W4380872018 hasConcept C134018914 @default.
• W4380872018 hasConcept C190283241 @default.
• W4380872018 hasConcept C196795494 @default.
• W4380872018 hasConcept C204232928 @default.
• W4380872018 hasConcept C2775909754 @default.
• W4380872018 hasConcept C2776151105 @default.
• W4380872018 hasConcept C2778198053 @default.
• W4380872018 hasConcept C2779537366 @default.
• W4380872018 hasConcept C2780559512 @default.
• W4380872018 hasConcept C55493867 @default.
• W4380872018 hasConcept C71924100 @default.
• W4380872018 hasConcept C86803240 @default.
• W4380872018 hasConcept C98274493 @default.
• W4380872018 hasConceptScore W4380872018C100817775 @default.
• W4380872018 hasConceptScore W4380872018C104317684 @default.
• W4380872018 hasConceptScore W4380872018C126322002 @default.
• W4380872018 hasConceptScore W4380872018C127561419 @default.
• W4380872018 hasConceptScore W4380872018C134018914 @default.
• W4380872018 hasConceptScore W4380872018C190283241 @default.
• W4380872018 hasConceptScore W4380872018C196795494 @default.
• W4380872018 hasConceptScore W4380872018C204232928 @default.
• W4380872018 hasConceptScore W4380872018C2775909754 @default.
• W4380872018 hasConceptScore W4380872018C2776151105 @default.
• W4380872018 hasConceptScore W4380872018C2778198053 @default.
• W4380872018 hasConceptScore W4380872018C2779537366 @default.
• W4380872018 hasConceptScore W4380872018C2780559512 @default.
• W4380872018 hasConceptScore W4380872018C55493867 @default.
• W4380872018 hasConceptScore W4380872018C71924100 @default.
• W4380872018 hasConceptScore W4380872018C86803240 @default.
• W4380872018 hasConceptScore W4380872018C98274493 @default.
• W4380872018 hasLocation W43808720181 @default.
• W4380872018 hasLocation W43808720182 @default.
• W4380872018 hasOpenAccess W4380872018 @default.
• W4380872018 hasPrimaryLocation W43808720181 @default.
• W4380872018 hasRelatedWork W2020449916 @default.
• W4380872018 hasRelatedWork W2025703417 @default.
• W4380872018 hasRelatedWork W2107729314 @default.
• W4380872018 hasRelatedWork W2132714283 @default.
• W4380872018 hasRelatedWork W2157270415 @default.
• W4380872018 hasRelatedWork W2349902393 @default.
• W4380872018 hasRelatedWork W2365308089 @default.
• W4380872018 hasRelatedWork W2409608972 @default.

• next