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• W4380872023 endingPage "e2318036" @default.
• W4380872023 startingPage "e2318036" @default.
• W4380872023 abstract "Importance With increasing altitude, the partial pressure of inspired oxygen decreases and, consequently, the Pa o 2 decreases. Even though this phenomenon is well known, the extent of the reduction as a function of altitude remains unknown. Objective To calculate an effect size estimate for the decrease in Pa o 2 with each kilometer of vertical gain among healthy unacclimatized adults and to identify factors associated with Pa o 2 at high altitude (HA). Data Sources A systematic search of PubMed and Embase was performed from database inception to April 11, 2023. Search terms included arterial blood gases and altitude . Study Selection A total of 53 peer-reviewed prospective studies in healthy adults providing results of arterial blood gas analysis at low altitude (&amp;lt;1500 m) and within the first 3 days at the target altitude (≥1500 m) were analyzed. Data Extraction and Synthesis Primary and secondary outcomes as well as study characteristics were extracted from the included studies, and individual participant data (IPD) were requested. Estimates were pooled using a random-effects DerSimonian-Laird model for the meta-analysis. Main Outcomes and Measures Mean effect size estimates and 95% CIs for reduction in Pa o 2 at HA and factors associated with Pa o 2 at HA in healthy adults. Results All of the 53 studies involving 777 adults (mean [SD] age, 36.2 [10.5] years; 510 men [65.6%]) reporting 115 group ascents to altitudes between 1524 m and 8730 m were included in the aggregated data analysis; 13 of those studies involving 305 individuals (mean [SD] age, 39.8 [13.6] years; 185 men [60.7%]) reporting 29 ascents were included in the IPD analysis. The estimated effect size of Pa o 2 was −1.60 kPa (95% CI, −1.73 to −1.47 kPa) for each 1000 m of altitude gain (τ 2 = 0.14; I 2 = 86%). The Pa o 2 estimation model based on IPD data revealed that target altitude (−1.53 kPa per 1000 m; 95% CI, −1.63 to −1.42 kPa per 1000 m), age (−0.01 kPa per year; 95% CI, −0.02 to −0.003 kPa per year), and time spent at an altitude of 1500 m or higher (0.16 kPa per day; 95% CI, 0.11-0.21 kPa per day) were significantly associated with Pa o 2 . Conclusions and Relevance In this systematic review and meta-analysis, the mean decrease in Pa o 2 was 1.60 kPa per 1000 m of vertical ascent. This effect size estimate may improve the understanding of physiological mechanisms, assist in the clinical interpretation of acute altitude illness in healthy individuals, and serve as a reference for physicians counseling patients with cardiorespiratory disease who are traveling to HA regions." @default.
• W4380872023 created "2023-06-17" @default.
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• W4380872023 date "2023-06-16" @default.
• W4380872023 modified "2023-10-14" @default.
• W4380872023 title "Partial Pressure of Arterial Oxygen in Healthy Adults at High Altitudes" @default.
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• W4380872023 doi "https://doi.org/10.1001/jamanetworkopen.2023.18036" @default.
• W4380872023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37326993" @default.
• W4380872023 hasPublicationYear "2023" @default.
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