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- W4380872786 abstract "A 16-year-old female patient with previously diagnosed acne vulgaris was transferred to our clinic in reduced general condition with rapidly progressive and extremely painful ulcerations. In the laboratory exam, inflammatory parameters were highly elevated, but she was normothermic. Based on the findings, we diagnosed multilocular pyoderma gangrenosum. Further investigations established the diagnosis of primary biliary cholangitis as the underlying condition. Treatment with systemic corticosteroids was initiated and we started therapy with ursodeoxycholic acid. This led to improvement within a few days. PAPA-syndrome (pyogenic arthritis, pyoderma gangrenosum and acne vulgaris) could be ruled out by genetic analysis.Vorstellung einer 16-jährigen Patientin mit vorbekannter Acne vulgaris in reduziertem Allgemeinzustand mit akut aufgetretenen, schmerzhaften Ulzerationen. Die Infektparameter zeigten sich stark erhöht, es bestand kein Fieber. Wir stellten die Diagnose eines multilokulären Pyoderma gangraenosum. Nebenbefundlich konnte eine primär biliäre Cholangitis diagnostiziert werden. Wir führten eine systemische Kortikosteroidtherapie durch sowie eine Therapie mit Ursodesoxycholsäure. Hierunter kam es zu einer raschen Besserung. Ein PAPA-Syndrom konnte humangenetisch ausgeschlossen werden." @default.
- W4380872786 created "2023-06-17" @default.
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- W4380872786 date "2023-06-16" @default.
- W4380872786 modified "2023-10-06" @default.
- W4380872786 title "Multilocular pyoderma gangrenosum" @default.
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- W4380872786 doi "https://doi.org/10.1007/s00105-023-05161-2" @default.
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