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- W4380873503 endingPage "106760" @default.
- W4380873503 startingPage "106760" @default.
- W4380873503 abstract "Ischemic cerebral stroke is a severe medical condition that affects about 15 million people every year and is the second leading cause of death and disability globally. Ischemic stroke results in neuronal cell death and neurological impairment. Current therapies may not adequately address the deleterious metabolic changes and may increase neurological damage. Oxygen and nutrient depletion along with the tissue damage result in endoplasmic reticulum (ER) stress, including the Unfolded Protein Response (UPR), and neuroinflammation in the affected area and cause cell death in the lesion core. The spatio-temporal production of lipid mediators, either pro-inflammatory or pro-resolving, decides the course and outcome of stroke. The modulation of the UPR as well as the resolution of inflammation promotes post-stroke cellular viability and neuroprotection. However, studies about the interplay between the UPR and bioactive lipid mediators remain elusive and this review gives insights about the crosstalk between lipid mediators and the UPR in ischemic stroke. Overall, the treatment of ischemic stroke is often inadequate due to lack of effective drugs, thus, this review will provide novel therapeutical strategies that could promote the functional recovery from ischemic stroke." @default.
- W4380873503 created "2023-06-17" @default.
- W4380873503 creator A5037106945 @default.
- W4380873503 creator A5050389590 @default.
- W4380873503 creator A5082042696 @default.
- W4380873503 creator A5085062932 @default.
- W4380873503 date "2023-10-01" @default.
- W4380873503 modified "2023-10-16" @default.
- W4380873503 title "Cross-talk between bioactive lipid mediators and the unfolded protein response in ischemic stroke" @default.
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