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- W4380876870 abstract "Abstract Background Sleep and related disorders could lead to changes in various brain network connectivities, but little is known about the role of Aβ burden—a key Alzheimer’s disease (AD) biomarker—in the relationship between sleep disturbance and altered functional connectivity in older adults. This study examined the association between sleep disturbance, Aβ positivity, and with‐in and between resting‐state functional connectivity networks using a large‐scale dataset from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Method Sample was consisted of 413 individuals (mean age 76.56±7.20; 57.5% cognitively normal, 30.3% mild cognitive impairment, and 12.1% AD) who had completed sleep measures (Neuropsychiatric Inventory), CSF‐Aβ42 data, and resting‐state fMRI scans at baseline. Functional connectivity within Salience (SN), Default Mode (DMN) and Frontal Parietal networks (FPN) were compared between participants with sleep disturbance versus without sleep disturbance. The interaction between Aβ positivity and sleep disturbance were evaluated controlling for age, diagnosis status, gender, sedatives and hypnotics use, and hypertension. Result Sleep disturbance was associated with reduced connectivity in the SN (β = 0.04, P = 0.006) but not with DMN or FPN. Additionally, sleep disturbance interacted significantly with Aβ positivity in altered with‐in connectivity of SN (β = 0.10, P = 0.003), DMN (β = 0.07, P = 0.0048), and FPN (β = 0.09, P = 0.03) networks. Conclusion Sleep disturbance may lead to altered connectivity in the SN and further change various within and between functional networks in the presence of amyloid burden." @default.
- W4380876870 created "2023-06-17" @default.
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- W4380876870 date "2023-06-01" @default.
- W4380876870 modified "2023-10-18" @default.
- W4380876870 title "Resting‐State Connectivity Changes in Older Adults with Sleep Disturbance" @default.
- W4380876870 doi "https://doi.org/10.1002/alz.062749" @default.
- W4380876870 hasPublicationYear "2023" @default.
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