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• W4380881344 abstract "Abstract Cognitive impairment is the most frequent non-motor symptom in Parkinson’s disease and is associated with deficits in a number of cognitive functions including working memory. However, the pathophysiology of Parkinson’s disease cognitive impairment is poorly understood. Beta oscillations have previously been shown to play an important role in cognitive functions including working memory encoding. Decreased dopamine in motor cortico-striato-thalamo-cortical (CSTC) circuits increases the spectral power of beta oscillations and results in Parkinson’s disease motor symptoms. Analogous changes in parallel cognitive CSTC circuits involving the caudate and dorsolateral prefrontal cortex (DLPFC) may contribute to Parkinson’s disease cognitive impairment. The objective of our study is to evaluate whether changes in beta oscillations in the caudate and DLPFC contribute to cognitive impairment in Parkinson’s disease patients. To investigate this, we used local field potential recordings during deep brain stimulation surgery in 15 patients with Parkinson’s disease. Local field potentials were recorded from DLPFC and caudate at rest and during a working memory task. We examined changes in beta oscillatory power during the working memory task as well as the relationship of beta oscillatory activity to preoperative cognitive status, as determined from neuropsychological testing results. We additionally conducted exploratory analyses on the relationship between cognitive impairment and task-based changes in spectral power in additional frequency bands. Spectral power of beta oscillations decreased in both DLPFC and caudate during working memory encoding and increased in these structures during feedback. Subjects with cognitive impairment had smaller decreases in caudate and DLPFC beta oscillatory power during encoding. In our exploratory analysis, we found that similar differences occurred in alpha frequencies in caudate and theta and alpha in DLPFC. Our findings suggest that oscillatory power changes in cognitive CSTC circuits may contribute to cognitive symptoms in patients with Parkinson’s disease. These findings may inform the future development of novel neuromodulatory treatments for cognitive impairment in Parkinson’s disease." @default.
• W4380881344 created "2023-06-17" @default.
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• W4380881344 date "2023-06-16" @default.
• W4380881344 modified "2023-10-15" @default.
• W4380881344 title "Corticostriatal beta oscillation changes associated with cognitive function in Parkinson’s disease" @default.
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• W4380881344 doi "https://doi.org/10.1093/brain/awad206" @default.
• W4380881344 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37327379" @default.
• W4380881344 hasPublicationYear "2023" @default.
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