Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380883038> ?p ?o ?g. }
- W4380883038 endingPage "167954" @default.
- W4380883038 startingPage "167954" @default.
- W4380883038 abstract "The flagellum is a sophisticated nanomachine responsible for motility in Gram-negative bacteria. Flagellar assembly is a strictly choreographed process, in which the motor and export gate are formed first, followed by the extracellular propeller structure. Extracellular flagellar components are escorted to the export gate by dedicated molecular chaperones for secretion and self-assembly at the apex of the emerging structure. The detailed mechanisms of chaperone-substrate trafficking at the export gate remain poorly understood. Here, we structurally characterized the interaction of Salmonella enterica late-stage flagellar chaperones FliT and FlgN with the export controller protein FliJ. Previous studies showed that FliJ is absolutely required for flagellar assembly since its interaction with chaperone-client complexes controls substrate delivery to the export gate. Our biophysical and cell-based data show that FliT and FlgN bind FliJ cooperatively, with high affinity and on specific sites. Chaperone binding completely disrupts the FliJ coiled-coil structure and alters its interactions with the export gate. We propose that FliJ aids the release of substrates from the chaperone and forms the basis of chaperone recycling during late-stage flagellar assembly." @default.
- W4380883038 created "2023-06-17" @default.
- W4380883038 creator A5017276788 @default.
- W4380883038 creator A5031531467 @default.
- W4380883038 creator A5037359596 @default.
- W4380883038 creator A5046466799 @default.
- W4380883038 creator A5058577851 @default.
- W4380883038 creator A5065657192 @default.
- W4380883038 creator A5076030250 @default.
- W4380883038 creator A5076998571 @default.
- W4380883038 creator A5074131391 @default.
- W4380883038 date "2023-06-01" @default.
- W4380883038 modified "2023-09-27" @default.
- W4380883038 title "Chaperone Recycling in Late-Stage Flagellar Assembly" @default.
- W4380883038 cites W1566222266 @default.
- W4380883038 cites W1883110457 @default.
- W4380883038 cites W190397328 @default.
- W4380883038 cites W1969164033 @default.
- W4380883038 cites W1980849514 @default.
- W4380883038 cites W1981571167 @default.
- W4380883038 cites W2001112725 @default.
- W4380883038 cites W2005449680 @default.
- W4380883038 cites W2031512166 @default.
- W4380883038 cites W2035729932 @default.
- W4380883038 cites W2048266405 @default.
- W4380883038 cites W2057686149 @default.
- W4380883038 cites W2062892191 @default.
- W4380883038 cites W2078421235 @default.
- W4380883038 cites W2097346348 @default.
- W4380883038 cites W2100112593 @default.
- W4380883038 cites W2101058428 @default.
- W4380883038 cites W2119034696 @default.
- W4380883038 cites W2133366275 @default.
- W4380883038 cites W2134295532 @default.
- W4380883038 cites W2136332525 @default.
- W4380883038 cites W2150228730 @default.
- W4380883038 cites W2160144480 @default.
- W4380883038 cites W2169821755 @default.
- W4380883038 cites W2179902466 @default.
- W4380883038 cites W2297129848 @default.
- W4380883038 cites W2401506608 @default.
- W4380883038 cites W2512079181 @default.
- W4380883038 cites W2555624997 @default.
- W4380883038 cites W2576918207 @default.
- W4380883038 cites W2591769382 @default.
- W4380883038 cites W2766011702 @default.
- W4380883038 cites W2800829833 @default.
- W4380883038 cites W2894369455 @default.
- W4380883038 cites W2914641431 @default.
- W4380883038 cites W3092344833 @default.
- W4380883038 cites W3155958193 @default.
- W4380883038 cites W3177828909 @default.
- W4380883038 cites W4200568296 @default.
- W4380883038 cites W4225376664 @default.
- W4380883038 cites W4281790889 @default.
- W4380883038 cites W4291972712 @default.
- W4380883038 doi "https://doi.org/10.1016/j.jmb.2023.167954" @default.
- W4380883038 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37330284" @default.
- W4380883038 hasPublicationYear "2023" @default.
- W4380883038 type Work @default.
- W4380883038 citedByCount "1" @default.
- W4380883038 countsByYear W43808830382023 @default.
- W4380883038 crossrefType "journal-article" @default.
- W4380883038 hasAuthorship W4380883038A5017276788 @default.
- W4380883038 hasAuthorship W4380883038A5031531467 @default.
- W4380883038 hasAuthorship W4380883038A5037359596 @default.
- W4380883038 hasAuthorship W4380883038A5046466799 @default.
- W4380883038 hasAuthorship W4380883038A5058577851 @default.
- W4380883038 hasAuthorship W4380883038A5065657192 @default.
- W4380883038 hasAuthorship W4380883038A5074131391 @default.
- W4380883038 hasAuthorship W4380883038A5076030250 @default.
- W4380883038 hasAuthorship W4380883038A5076998571 @default.
- W4380883038 hasBestOaLocation W43808830381 @default.
- W4380883038 hasConcept C115811362 @default.
- W4380883038 hasConcept C12554922 @default.
- W4380883038 hasConcept C142724271 @default.
- W4380883038 hasConcept C2775962898 @default.
- W4380883038 hasConcept C2779607309 @default.
- W4380883038 hasConcept C2781065037 @default.
- W4380883038 hasConcept C28406088 @default.
- W4380883038 hasConcept C49039625 @default.
- W4380883038 hasConcept C523546767 @default.
- W4380883038 hasConcept C54355233 @default.
- W4380883038 hasConcept C55493867 @default.
- W4380883038 hasConcept C58207958 @default.
- W4380883038 hasConcept C71924100 @default.
- W4380883038 hasConcept C86803240 @default.
- W4380883038 hasConcept C95444343 @default.
- W4380883038 hasConceptScore W4380883038C115811362 @default.
- W4380883038 hasConceptScore W4380883038C12554922 @default.
- W4380883038 hasConceptScore W4380883038C142724271 @default.
- W4380883038 hasConceptScore W4380883038C2775962898 @default.
- W4380883038 hasConceptScore W4380883038C2779607309 @default.
- W4380883038 hasConceptScore W4380883038C2781065037 @default.
- W4380883038 hasConceptScore W4380883038C28406088 @default.
- W4380883038 hasConceptScore W4380883038C49039625 @default.
- W4380883038 hasConceptScore W4380883038C523546767 @default.
- W4380883038 hasConceptScore W4380883038C54355233 @default.