FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380883212> ?p ?o ?g. }

• W4380883212 abstract "Abstract Background Several cohort studies have recently reported associations between late‐life psychosis and dementia, and postmortem studies have demonstrated that most individuals with late‐onset schizophrenia and delusional disorder had tau pathologies. The present study was aimed to assess the prevalence and topology of tau pathologies by positron emission tomography (PET) with a specific probe, 18 F‐PM‐PBB3 ( 18 F‐APN‐1607), in patients with late‐onset psychosis (LOP). Method We included LOP patients who experienced the first episode of psychosis after 65 years old and excluded those with dementia. Fourteen patients with LOC (74.2 ± 4.0 years old; 7 females and 7 males)and 16 age‐matched healthy controls (HCs) (72.6 ± 5.7 years old; 9 females and 7 males) underwent PET scans with 18 F‐PM‐PBB3 and an amyloid‐β probe, 11 C‐PiB. The radioprobe retention was calculated as standardized uptake value ratio (SUVR), and the laterality index (LI) of SUVR was estimated as [Left‐Right/(Left+Right)]. We compared 18 F‐PM‐PBB3 SUVRs and LIs in the frontal, temporal, parietal, and occipital cortices between patients and HCs using an independent t ‐test after Bonferroni correction ( p ‐value ≤ 0.05/4). Result All HCs were negative for 11 C‐PiB‐PET. By contrast, unequivocally increased 18 F‐PM‐PBB3 retentions were found in 4 out of 4 11 C‐PiB‐positive patients (100%) and 7 out of 10 11 C‐PiB‐negative patients (70%) with variable localizations. Tau topologies in four 11 C‐PiB‐positive cases were characteristic of Alzheimer’s disease and consisted of limbic predominant (N = 2), medial temporal lobe‐sparing (N = 1), and lateral temporal (N = 1) deposition subtypes. Meanwhile, tau topologies in 7 11 C‐PiB‐negative cases were composed of lateral‐posterior diffuse (N = 3), posterior mild (N = 2), lateral temporal local (N = 1), and progressive supranuclear palsy‐like (N = 1) accumulations. None of the target regions exhibited significant differences in 18 F‐PM‐PBB3 SUVR between patients and HCs, reflecting the heterogeneous distributions of tau deposits in patients. There was significant rightward lateralization of tau pathologies indicated by a reduced LI in the frontal cortex ( P = 0.0093) but not the other cortical regions. Conclusion Our findings indicate that LOP is associated with tau topologies of diverse Alzheimer’s and non‐Alzheimer’s disease subtypes. The rightward lateralization of tau pathologies in the frontal cortex might be involved in the development of psychotic manifestations." @default.
• W4380883212 created "2023-06-17" @default.
• W4380883212 creator A5000844496 @default.
• W4380883212 creator A5001695445 @default.
• W4380883212 creator A5002819177 @default.
• W4380883212 creator A5006864791 @default.
• W4380883212 creator A5009790212 @default.
• W4380883212 creator A5013804286 @default.
• W4380883212 creator A5015359046 @default.
• W4380883212 creator A5023585260 @default.
• W4380883212 creator A5026143979 @default.
• W4380883212 creator A5026847461 @default.
• W4380883212 creator A5030948491 @default.
• W4380883212 creator A5033519257 @default.
• W4380883212 creator A5035701410 @default.
• W4380883212 creator A5039084458 @default.
• W4380883212 creator A5039702191 @default.
• W4380883212 creator A5048387675 @default.
• W4380883212 creator A5057023665 @default.
• W4380883212 creator A5060847562 @default.
• W4380883212 creator A5064000180 @default.
• W4380883212 creator A5065111183 @default.
• W4380883212 creator A5065692454 @default.
• W4380883212 creator A5068994256 @default.
• W4380883212 creator A5077873549 @default.
• W4380883212 creator A5079225739 @default.
• W4380883212 creator A5090255837 @default.
• W4380883212 creator A5090325884 @default.
• W4380883212 date "2023-06-01" @default.
• W4380883212 modified "2023-09-27" @default.
• W4380883212 title "Rightward lateralization of frontal cortex tau pathologies is associated with late‐onset psychosis: A PET study with ¹⁸F‐PM‐PBB3" @default.
• W4380883212 doi "https://doi.org/10.1002/alz.065288" @default.
• W4380883212 hasPublicationYear "2023" @default.
• W4380883212 type Work @default.
• W4380883212 citedByCount "0" @default.
• W4380883212 crossrefType "journal-article" @default.
• W4380883212 hasAuthorship W4380883212A5000844496 @default.
• W4380883212 hasAuthorship W4380883212A5001695445 @default.
• W4380883212 hasAuthorship W4380883212A5002819177 @default.
• W4380883212 hasAuthorship W4380883212A5006864791 @default.
• W4380883212 hasAuthorship W4380883212A5009790212 @default.
• W4380883212 hasAuthorship W4380883212A5013804286 @default.
• W4380883212 hasAuthorship W4380883212A5015359046 @default.
• W4380883212 hasAuthorship W4380883212A5023585260 @default.
• W4380883212 hasAuthorship W4380883212A5026143979 @default.
• W4380883212 hasAuthorship W4380883212A5026847461 @default.
• W4380883212 hasAuthorship W4380883212A5030948491 @default.
• W4380883212 hasAuthorship W4380883212A5033519257 @default.
• W4380883212 hasAuthorship W4380883212A5035701410 @default.
• W4380883212 hasAuthorship W4380883212A5039084458 @default.
• W4380883212 hasAuthorship W4380883212A5039702191 @default.
• W4380883212 hasAuthorship W4380883212A5048387675 @default.
• W4380883212 hasAuthorship W4380883212A5057023665 @default.
• W4380883212 hasAuthorship W4380883212A5060847562 @default.
• W4380883212 hasAuthorship W4380883212A5064000180 @default.
• W4380883212 hasAuthorship W4380883212A5065111183 @default.
• W4380883212 hasAuthorship W4380883212A5065692454 @default.
• W4380883212 hasAuthorship W4380883212A5068994256 @default.
• W4380883212 hasAuthorship W4380883212A5077873549 @default.
• W4380883212 hasAuthorship W4380883212A5079225739 @default.
• W4380883212 hasAuthorship W4380883212A5090255837 @default.
• W4380883212 hasAuthorship W4380883212A5090325884 @default.
• W4380883212 hasBestOaLocation W43808832121 @default.
• W4380883212 hasConcept C118552586 @default.
• W4380883212 hasConcept C126322002 @default.
• W4380883212 hasConcept C15744967 @default.
• W4380883212 hasConcept C2775842073 @default.
• W4380883212 hasConcept C2779134260 @default.
• W4380883212 hasConcept C2779483572 @default.
• W4380883212 hasConcept C2779727114 @default.
• W4380883212 hasConcept C2989005 @default.
• W4380883212 hasConcept C548259974 @default.
• W4380883212 hasConcept C71924100 @default.
• W4380883212 hasConcept C79840881 @default.
• W4380883212 hasConceptScore W4380883212C118552586 @default.
• W4380883212 hasConceptScore W4380883212C126322002 @default.
• W4380883212 hasConceptScore W4380883212C15744967 @default.
• W4380883212 hasConceptScore W4380883212C2775842073 @default.
• W4380883212 hasConceptScore W4380883212C2779134260 @default.
• W4380883212 hasConceptScore W4380883212C2779483572 @default.
• W4380883212 hasConceptScore W4380883212C2779727114 @default.
• W4380883212 hasConceptScore W4380883212C2989005 @default.
• W4380883212 hasConceptScore W4380883212C548259974 @default.
• W4380883212 hasConceptScore W4380883212C71924100 @default.
• W4380883212 hasConceptScore W4380883212C79840881 @default.
• W4380883212 hasIssue "S4" @default.
• W4380883212 hasLocation W43808832121 @default.
• W4380883212 hasOpenAccess W4380883212 @default.
• W4380883212 hasPrimaryLocation W43808832121 @default.
• W4380883212 hasRelatedWork W178129863 @default.
• W4380883212 hasRelatedWork W1975223088 @default.
• W4380883212 hasRelatedWork W2024410590 @default.
• W4380883212 hasRelatedWork W2210203834 @default.
• W4380883212 hasRelatedWork W2547290912 @default.
• W4380883212 hasRelatedWork W2748952813 @default.
• W4380883212 hasRelatedWork W2766344826 @default.
• W4380883212 hasRelatedWork W2899084033 @default.
• W4380883212 hasRelatedWork W3007887826 @default.
• W4380883212 hasRelatedWork W3185944674 @default.
• W4380883212 hasVolume "19" @default.

• next