FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380883681> ?p ?o ?g. }

• W4380883681 abstract "Abstract Background Given the growing population of aging adults, and subsequently individuals with dementia, there is a need for instruments that can detect cognitive impairment in early stages. The NIH Toolbox ® for Assessment of Neurological and Behavioral Function (NIHTB) is a computerized battery of assessments measuring multiple domains cognition, emotion, sensation, and motor abilities. The goal of the ARMADA study is to validate the NIHTB in individuals with mild cognitive impairment (MCI) and dementia of the Alzheimer type (DAT). Here, we describe the demographic and clinical characteristics of participants ages 65 to 85 from the general population sample. Method Normal control (NC), MCI, and DAT groups racially proportional to the US population were recruited from existing cohorts across nine Alzheimer’s Disease Research Centers and sites with cognitive aging studies. Diagnoses were based on the Uniform Data Set methodology, and included multiple clinical and cognitive assessments. Participants completed the NIH Toolbox at baseline, 12‐, and 24‐month visits. Result Groups were matched with respect to multiple demographic characteristics. There were some differences in age and sex, such that the NC group had more female participants and was the youngest. Dementia severity levels differed as expected, with the DAT group demonstrating greater cognitive and functional impairment compared to the MCI group, and the NC group demonstrating minimal cognitive or functional symptoms. Additionally, the DAT group reported more neuropsychiatric symptoms compared to the NC and MCI groups. There was no difference in reported family history of cognitive impairment across groups. Many participants across groups had at least one Alzheimer biomarker collected. Conclusion The study cohorts included in the ARMADA study accurately reflect their respective clinical syndromes for validating the NIHTB across the cognitive aging spectrum. The goals for the ARMADA study include comparing performance on all four modules of the NIHTB across groups, evaluating the relationship between Alzheimer biomarkers and NIHTB measures, and measuring changes in performance longitudinally. Special emphasis groups, including individuals over age 85, African American participants, and Spanish‐Speaking participants, were also recruited and are reported elsewhere." @default.
• W4380883681 created "2023-06-17" @default.
• W4380883681 creator A5002198243 @default.
• W4380883681 creator A5002754020 @default.
• W4380883681 creator A5002838384 @default.
• W4380883681 creator A5005174716 @default.
• W4380883681 creator A5013965600 @default.
• W4380883681 creator A5021979900 @default.
• W4380883681 creator A5028803412 @default.
• W4380883681 creator A5059468967 @default.
• W4380883681 creator A5066244316 @default.
• W4380883681 creator A5071076619 @default.
• W4380883681 date "2023-06-01" @default.
• W4380883681 modified "2023-09-27" @default.
• W4380883681 title "Description of the ARMADA (assessing reliable measurement in Alzheimer’s disease) general population study cohorts" @default.
• W4380883681 doi "https://doi.org/10.1002/alz.068172" @default.
• W4380883681 hasPublicationYear "2023" @default.
• W4380883681 type Work @default.
• W4380883681 citedByCount "0" @default.
• W4380883681 crossrefType "journal-article" @default.
• W4380883681 hasAuthorship W4380883681A5002198243 @default.
• W4380883681 hasAuthorship W4380883681A5002754020 @default.
• W4380883681 hasAuthorship W4380883681A5002838384 @default.
• W4380883681 hasAuthorship W4380883681A5005174716 @default.
• W4380883681 hasAuthorship W4380883681A5013965600 @default.
• W4380883681 hasAuthorship W4380883681A5021979900 @default.
• W4380883681 hasAuthorship W4380883681A5028803412 @default.
• W4380883681 hasAuthorship W4380883681A5059468967 @default.
• W4380883681 hasAuthorship W4380883681A5066244316 @default.
• W4380883681 hasAuthorship W4380883681A5071076619 @default.
• W4380883681 hasBestOaLocation W43808836811 @default.
• W4380883681 hasConcept C118552586 @default.
• W4380883681 hasConcept C126322002 @default.
• W4380883681 hasConcept C15744967 @default.
• W4380883681 hasConcept C169900460 @default.
• W4380883681 hasConcept C2779134260 @default.
• W4380883681 hasConcept C2779483572 @default.
• W4380883681 hasConcept C2908647359 @default.
• W4380883681 hasConcept C2984863031 @default.
• W4380883681 hasConcept C2984915365 @default.
• W4380883681 hasConcept C502032728 @default.
• W4380883681 hasConcept C6057870 @default.
• W4380883681 hasConcept C70410870 @default.
• W4380883681 hasConcept C71924100 @default.
• W4380883681 hasConcept C74909509 @default.
• W4380883681 hasConcept C99454951 @default.
• W4380883681 hasConceptScore W4380883681C118552586 @default.
• W4380883681 hasConceptScore W4380883681C126322002 @default.
• W4380883681 hasConceptScore W4380883681C15744967 @default.
• W4380883681 hasConceptScore W4380883681C169900460 @default.
• W4380883681 hasConceptScore W4380883681C2779134260 @default.
• W4380883681 hasConceptScore W4380883681C2779483572 @default.
• W4380883681 hasConceptScore W4380883681C2908647359 @default.
• W4380883681 hasConceptScore W4380883681C2984863031 @default.
• W4380883681 hasConceptScore W4380883681C2984915365 @default.
• W4380883681 hasConceptScore W4380883681C502032728 @default.
• W4380883681 hasConceptScore W4380883681C6057870 @default.
• W4380883681 hasConceptScore W4380883681C70410870 @default.
• W4380883681 hasConceptScore W4380883681C71924100 @default.
• W4380883681 hasConceptScore W4380883681C74909509 @default.
• W4380883681 hasConceptScore W4380883681C99454951 @default.
• W4380883681 hasIssue "S4" @default.
• W4380883681 hasLocation W43808836811 @default.
• W4380883681 hasOpenAccess W4380883681 @default.
• W4380883681 hasPrimaryLocation W43808836811 @default.
• W4380883681 hasRelatedWork W1795231348 @default.
• W4380883681 hasRelatedWork W182016951 @default.
• W4380883681 hasRelatedWork W1990715639 @default.
• W4380883681 hasRelatedWork W2064114605 @default.
• W4380883681 hasRelatedWork W2070165017 @default.
• W4380883681 hasRelatedWork W2077992747 @default.
• W4380883681 hasRelatedWork W2561267217 @default.
• W4380883681 hasRelatedWork W2905731172 @default.
• W4380883681 hasRelatedWork W3030527225 @default.
• W4380883681 hasRelatedWork W4312389194 @default.
• W4380883681 hasVolume "19" @default.
• W4380883681 isParatext "false" @default.
• W4380883681 isRetracted "false" @default.
• W4380883681 workType "article" @default.