Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380883952> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W4380883952 abstract "Abstract Background Previous research has linked specific modifiable lifestyle factors to age‐related cognitive decline in adults. Little is known about the potential role of an overall healthy lifestyle in brain structure. We investigated the association of adherence to a combination of healthy lifestyle factors with neurodegeneration‐related brain structural markers in middle‐aged and older adults. Method We conducted a cross‐sectional analysis in the PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events (PRECISE) study among Chinese community‐dwelling elderly adults. Participants underwent lifestyle assessments and brain 3T MRI scanning between 2017‐2019. A healthy lifestyle score (0‐5) was constructed based on five modifiable lifestyle factors: diversified diet, physically active, non‐smoking, non‐alcohol‐drinking, and healthy body weight. Validated multimodal neuroimaging markers (across tissue volume, cortical thickness, and white matter micro‐structure, etc) were derived from MRI. Multivariable‐adjusted linear and logistic regression models were used to examine the associations. Result A total of 2370 participants (mean age 61.3 years; 53.9% female) was included in the final analysis. Compared to participants with lower healthy lifestyle score (0‐1), those with a higher lifestyle score had larger gray matter volume (GMV; β score 2‐3 = 0.34; β score 4‐5 = 0.31; p‐trend = 0.02) and lower odds of white matter hyperintensity (WMH; Odds Ratio [OR] score 2‐3 = 0.71, 95% Confidence Interval [CI]: 0.50, 1.02; OR score 4‐5 = 0.56, 95%CI: 0.35, 0.90; p‐trend = 0.003) and lacune (OR score 2‐3 = 0.62, 95%CI: 0.36, 1.06; OR score 4‐5 = 0.42, 95%CI: 0.18, 0.98; p‐trend = 0.02). In particular, diversified diet was associated with a significant lower risk of WMH and healthy body weight was associated with a variety of brain structure measures. Similar associations were observed across major subgroup variables. Conclusion Adherence to a healthier lifestyle was associated with a lower degree of neurodegeneration‐related brain structural markers in middle‐aged and older adults. Further large‐scale and longitudinal studies are warranted to confirm the study findings." @default.
- W4380883952 created "2023-06-17" @default.
- W4380883952 creator A5000848930 @default.
- W4380883952 creator A5037013675 @default.
- W4380883952 creator A5048940582 @default.
- W4380883952 creator A5050875699 @default.
- W4380883952 creator A5058151873 @default.
- W4380883952 creator A5065999911 @default.
- W4380883952 creator A5079464961 @default.
- W4380883952 creator A5088557959 @default.
- W4380883952 creator A5089894146 @default.
- W4380883952 date "2023-06-01" @default.
- W4380883952 modified "2023-09-27" @default.
- W4380883952 title "Adherence to a healthy lifestyle and brain structural imaging markers: A cross‐sectional study among middle‐aged and older adults" @default.
- W4380883952 doi "https://doi.org/10.1002/alz.062825" @default.
- W4380883952 hasPublicationYear "2023" @default.
- W4380883952 type Work @default.
- W4380883952 citedByCount "0" @default.
- W4380883952 crossrefType "journal-article" @default.
- W4380883952 hasAuthorship W4380883952A5000848930 @default.
- W4380883952 hasAuthorship W4380883952A5037013675 @default.
- W4380883952 hasAuthorship W4380883952A5048940582 @default.
- W4380883952 hasAuthorship W4380883952A5050875699 @default.
- W4380883952 hasAuthorship W4380883952A5058151873 @default.
- W4380883952 hasAuthorship W4380883952A5065999911 @default.
- W4380883952 hasAuthorship W4380883952A5079464961 @default.
- W4380883952 hasAuthorship W4380883952A5088557959 @default.
- W4380883952 hasAuthorship W4380883952A5089894146 @default.
- W4380883952 hasBestOaLocation W43808839521 @default.
- W4380883952 hasConcept C118552586 @default.
- W4380883952 hasConcept C126322002 @default.
- W4380883952 hasConcept C126838900 @default.
- W4380883952 hasConcept C142052008 @default.
- W4380883952 hasConcept C142724271 @default.
- W4380883952 hasConcept C143409427 @default.
- W4380883952 hasConcept C146638467 @default.
- W4380883952 hasConcept C151956035 @default.
- W4380883952 hasConcept C156957248 @default.
- W4380883952 hasConcept C44249647 @default.
- W4380883952 hasConcept C58693492 @default.
- W4380883952 hasConcept C65835030 @default.
- W4380883952 hasConcept C71924100 @default.
- W4380883952 hasConcept C74909509 @default.
- W4380883952 hasConceptScore W4380883952C118552586 @default.
- W4380883952 hasConceptScore W4380883952C126322002 @default.
- W4380883952 hasConceptScore W4380883952C126838900 @default.
- W4380883952 hasConceptScore W4380883952C142052008 @default.
- W4380883952 hasConceptScore W4380883952C142724271 @default.
- W4380883952 hasConceptScore W4380883952C143409427 @default.
- W4380883952 hasConceptScore W4380883952C146638467 @default.
- W4380883952 hasConceptScore W4380883952C151956035 @default.
- W4380883952 hasConceptScore W4380883952C156957248 @default.
- W4380883952 hasConceptScore W4380883952C44249647 @default.
- W4380883952 hasConceptScore W4380883952C58693492 @default.
- W4380883952 hasConceptScore W4380883952C65835030 @default.
- W4380883952 hasConceptScore W4380883952C71924100 @default.
- W4380883952 hasConceptScore W4380883952C74909509 @default.
- W4380883952 hasIssue "S8" @default.
- W4380883952 hasLocation W43808839521 @default.
- W4380883952 hasOpenAccess W4380883952 @default.
- W4380883952 hasPrimaryLocation W43808839521 @default.
- W4380883952 hasRelatedWork W2037611947 @default.
- W4380883952 hasRelatedWork W2138334887 @default.
- W4380883952 hasRelatedWork W2218945907 @default.
- W4380883952 hasRelatedWork W2335988042 @default.
- W4380883952 hasRelatedWork W2583387738 @default.
- W4380883952 hasRelatedWork W2971695752 @default.
- W4380883952 hasRelatedWork W3010075638 @default.
- W4380883952 hasRelatedWork W4293569637 @default.
- W4380883952 hasRelatedWork W4322739880 @default.
- W4380883952 hasRelatedWork W4379095627 @default.
- W4380883952 hasVolume "19" @default.
- W4380883952 isParatext "false" @default.
- W4380883952 isRetracted "false" @default.
- W4380883952 workType "article" @default.