Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380884046> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W4380884046 abstract "Abstract Background Social isolation (SI) is considered a modifiable risk factor for cognitive decline and dementia, is associated with unhealthy lifestyle. We investigated independent and combined associations of SI and lifestyle with cognitive functioning (CF) in a midlife to early‐late life population without dementia. This informs developing more targeted preventive strategies against cognitive decline and dementia. Method The “LIfestyle for BRAin health” (LIBRA) score was computed for 6,203 baseline participants of the LIFE‐Adult‐Study, a population‐based German cohort. LIBRA is validated for dementia prediction in midlife to early‐late life populations, consisting of 12 modifiable factors (heart disease, kidney disease, diabetes, obesity, hypertension, hypercholesterolemia, alcohol consumption, smoking, physical inactivity, diet, depression, cognitive activity). Higher scores (‐5.9,+12.7) indicate “worse” lifestyle. SI was assessed with the short Lubben Social Network Scale (score < 12). For CF, we calculated a z‐standardized composite score of the Verbal Fluency Test, the Trail Making Test A and B. Associations of SI and LIBRA with CF were investigated using generalized linear modelling. Bootstrapped structural equation modelling (SEM) tested whether LIBRA mediated the association between SI and CF. Sampling weights were applied, variables z‐standardized for SEM. Results Participants were M = 57.7 (SD = 12.0, range: 40‐79) years old; 50.7% were female; 15.8% were socially isolated. SI (β: ‐.17, 95%CI[‐.24,‐.10]; Wald = 21.45, p < .001) and a higher LIBRA score (β: ‐.03, 95%CI[‐.04,‐.02]; Wald = 31.49, p < .001) were independently associated with lower CF; there was no interaction (β: ‐.003, 95%CI[‐.03,.02]; Wald = 0.06, p = .814; Fig.1). Bootstrapped SEM (reps = 10,000; R² = .34) indicated that LIBRA partially mediated the association between SI and CF (IE = ‐.006, 95%CI[‐.008,‐.003], p < .001; proportion mediated = 8.5%; Fig.2). Conclusion CF is lower in socially isolated than socially integrated individuals without dementia. The CF difference can be partially attributed to modifiable health and lifestyle factors; however, only to a small extent. Therefore, public health initiatives aiming at preventing SI might be more effective in promoting good CF than lifestyle interventions in socially isolated individuals in midlife to early‐late life. This would likely benefit risk reduction of cognitive decline and dementia in later life." @default.
- W4380884046 created "2023-06-17" @default.
- W4380884046 creator A5010133468 @default.
- W4380884046 creator A5020270555 @default.
- W4380884046 creator A5025964385 @default.
- W4380884046 creator A5027082377 @default.
- W4380884046 creator A5040996543 @default.
- W4380884046 creator A5045258788 @default.
- W4380884046 creator A5066801947 @default.
- W4380884046 date "2023-06-01" @default.
- W4380884046 modified "2023-09-27" @default.
- W4380884046 title "Social isolation, lifestyle and cognitive functioning in midlife and early‐late life: Implications for risk reduction of cognitive decline and dementia" @default.
- W4380884046 doi "https://doi.org/10.1002/alz.061194" @default.
- W4380884046 hasPublicationYear "2023" @default.
- W4380884046 type Work @default.
- W4380884046 citedByCount "0" @default.
- W4380884046 crossrefType "journal-article" @default.
- W4380884046 hasAuthorship W4380884046A5010133468 @default.
- W4380884046 hasAuthorship W4380884046A5020270555 @default.
- W4380884046 hasAuthorship W4380884046A5025964385 @default.
- W4380884046 hasAuthorship W4380884046A5027082377 @default.
- W4380884046 hasAuthorship W4380884046A5040996543 @default.
- W4380884046 hasAuthorship W4380884046A5045258788 @default.
- W4380884046 hasAuthorship W4380884046A5066801947 @default.
- W4380884046 hasBestOaLocation W43808840461 @default.
- W4380884046 hasConcept C105795698 @default.
- W4380884046 hasConcept C118552586 @default.
- W4380884046 hasConcept C126322002 @default.
- W4380884046 hasConcept C14216870 @default.
- W4380884046 hasConcept C15744967 @default.
- W4380884046 hasConcept C169900460 @default.
- W4380884046 hasConcept C185711340 @default.
- W4380884046 hasConcept C2776893239 @default.
- W4380884046 hasConcept C2779134260 @default.
- W4380884046 hasConcept C2779483572 @default.
- W4380884046 hasConcept C2781357127 @default.
- W4380884046 hasConcept C2908647359 @default.
- W4380884046 hasConcept C2984863031 @default.
- W4380884046 hasConcept C33923547 @default.
- W4380884046 hasConcept C70410870 @default.
- W4380884046 hasConcept C71104824 @default.
- W4380884046 hasConcept C71924100 @default.
- W4380884046 hasConcept C72563966 @default.
- W4380884046 hasConcept C74909509 @default.
- W4380884046 hasConcept C97530452 @default.
- W4380884046 hasConcept C99454951 @default.
- W4380884046 hasConceptScore W4380884046C105795698 @default.
- W4380884046 hasConceptScore W4380884046C118552586 @default.
- W4380884046 hasConceptScore W4380884046C126322002 @default.
- W4380884046 hasConceptScore W4380884046C14216870 @default.
- W4380884046 hasConceptScore W4380884046C15744967 @default.
- W4380884046 hasConceptScore W4380884046C169900460 @default.
- W4380884046 hasConceptScore W4380884046C185711340 @default.
- W4380884046 hasConceptScore W4380884046C2776893239 @default.
- W4380884046 hasConceptScore W4380884046C2779134260 @default.
- W4380884046 hasConceptScore W4380884046C2779483572 @default.
- W4380884046 hasConceptScore W4380884046C2781357127 @default.
- W4380884046 hasConceptScore W4380884046C2908647359 @default.
- W4380884046 hasConceptScore W4380884046C2984863031 @default.
- W4380884046 hasConceptScore W4380884046C33923547 @default.
- W4380884046 hasConceptScore W4380884046C70410870 @default.
- W4380884046 hasConceptScore W4380884046C71104824 @default.
- W4380884046 hasConceptScore W4380884046C71924100 @default.
- W4380884046 hasConceptScore W4380884046C72563966 @default.
- W4380884046 hasConceptScore W4380884046C74909509 @default.
- W4380884046 hasConceptScore W4380884046C97530452 @default.
- W4380884046 hasConceptScore W4380884046C99454951 @default.
- W4380884046 hasIssue "S8" @default.
- W4380884046 hasLocation W43808840461 @default.
- W4380884046 hasOpenAccess W4380884046 @default.
- W4380884046 hasPrimaryLocation W43808840461 @default.
- W4380884046 hasRelatedWork W1994124622 @default.
- W4380884046 hasRelatedWork W2135825444 @default.
- W4380884046 hasRelatedWork W2598360307 @default.
- W4380884046 hasRelatedWork W2766474056 @default.
- W4380884046 hasRelatedWork W2905867401 @default.
- W4380884046 hasRelatedWork W2964244176 @default.
- W4380884046 hasRelatedWork W2977234399 @default.
- W4380884046 hasRelatedWork W2989661089 @default.
- W4380884046 hasRelatedWork W4200328527 @default.
- W4380884046 hasRelatedWork W4226451462 @default.
- W4380884046 hasVolume "19" @default.
- W4380884046 isParatext "false" @default.
- W4380884046 isRetracted "false" @default.
- W4380884046 workType "article" @default.