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- W4380884059 abstract "Abstract Background The resting state eyes‐closed electroencephalographic (rsEEG) alpha (8‐12 Hz) rhythms reflect cortical neural synchronization mechanisms underpinning the inhibition of sensory, cognitive, and motor areas in parietal, temporal, and occipital cortex during a condition of low vigilance. Here we tested the hypothesis that age may diversely affect rsEEG alpha (8‐12 Hz) rhythms recorded in normal elderly (Nold) seniors and patients with Alzheimer’s disease and mild cognitive impairment (ADMCI). Method Clinical, magnetic resonance imaging (MRI) and rsEEG datasets in 63 ADMCI and 60 Nold individuals were taken from an international archive. The rsEEG rhythms were investigated at individual delta, theta, and alpha frequency bands as well as fixed beta (14‐30 Hz) and gamma (30‐40 Hz) bands. Each group was stratified into three subgroups based on age ranges (i.e., tertiles). Result As compared to the younger Nold subgroups, the older one showed greater reductions in the rsEEG alpha rhythms with major topographical effects in posterior regions (Figure 1). On the contrary, in relation to the younger ADMCI subgroups, the older one displayed lesser reduction in those rhythms (Figure 1). Furthermore, a decrease in the total grey matter (GM) volume and total cortical thickness as well as an increase in the white matter (WM) hypointensity were found in the older ADMCI subgroups compared to the younger ADMCI subgroups (Figure 2). Conclusion The results of the present study suggest that in Nold seniors, the aging factor may significantly affect neurophysiological brain neural synchronization mechanisms underpinning the generation of dominant rsEEG alpha rhythms. In contrast, rsEEG alpha rhythms in ADMCI patients may be more affected by the disease variants, with more deleterious effects observed in early‐ than the late‐onset ADMCI patients. In the ADMCI patients, the mere effects of the aging factor may be hidden by dysfunctions in subcortical structures, including the cholinergic basal forebrain and thalamus." @default.
- W4380884059 created "2023-06-17" @default.
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- W4380884059 date "2023-06-01" @default.
- W4380884059 modified "2023-09-27" @default.
- W4380884059 title "Brain neural synchronization mechanisms are affected by aging in cognitively unimpaired seniors and patients with Alzheimer’s disease and mild cognitive impairment" @default.
- W4380884059 doi "https://doi.org/10.1002/alz.062176" @default.
- W4380884059 hasPublicationYear "2023" @default.
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