Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380884065> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W4380884065 abstract "Abstract Background High cognitive reserve (CR) has been related to a decreased dementia risk, but the association between CR and survival with independence is unknown. We examined whether lifelong CR accumulation is associated with disability‐free survival and explored the extent to which cognitive function mediates this association. Method Within the Rush Memory and Aging Project, 1,633 dementia‐ and disability‐free participants (mean age: 79.3 years) were followed annually for up to 22 years to detect disability and deaths. A lifelong CR indicator was derived based on information about education, early‐life, mid‐life, and late‐life cognitive activities, and late‐life social activity, and categorized into tertiles (low, moderate, and high). Disability was assessed annually in terms of participants’ ability to conduct activities of daily living and survival status was observed during the follow‐up period. Global cognitive function was assessed annually with a battery of 19 tests. Data were analyzed using Cox models, Laplace regression, and generalized structural equation models. Result During the follow‐up (median: 4.35 years, interquartile range: 2.01 to 7.98 years), 1,079 (64.6%) participants died or developed disability. In multi‐adjusted Cox models, CR score was does‐dependently associated with disability/death (hazard ratio [HR] 0.96, confidence interval [CI] 0.93–0.99). Compared to low CR, the multi‐adjusted HR (95% CI) of high CR was 0.82 (0.70–0.95) for disability/death. In Laplace regression, the median disability‐free survival time was prolonged by 0.17 (95% CI 0.05–0.30) years per unit higher CR score, and 0.99 (95% CI 0.28–1.71) years for participants with high CR compared to low CR. In mediation analysis, cognitive function mediated 35.7% of the association between CR and disability‐free survival. Conclusion High lifelong CR is associated with prolonged disability‐free survival, and cognitive function mediates about one‐third of this association." @default.
- W4380884065 created "2023-06-17" @default.
- W4380884065 creator A5014075642 @default.
- W4380884065 creator A5024473114 @default.
- W4380884065 creator A5041863516 @default.
- W4380884065 creator A5050971981 @default.
- W4380884065 creator A5060809049 @default.
- W4380884065 creator A5070632299 @default.
- W4380884065 creator A5079534445 @default.
- W4380884065 date "2023-06-01" @default.
- W4380884065 modified "2023-10-02" @default.
- W4380884065 title "High lifelong cognitive reserve prolongs disability‐free survival: Role of cognitive function" @default.
- W4380884065 doi "https://doi.org/10.1002/alz.061430" @default.
- W4380884065 hasPublicationYear "2023" @default.
- W4380884065 type Work @default.
- W4380884065 citedByCount "0" @default.
- W4380884065 crossrefType "journal-article" @default.
- W4380884065 hasAuthorship W4380884065A5014075642 @default.
- W4380884065 hasAuthorship W4380884065A5024473114 @default.
- W4380884065 hasAuthorship W4380884065A5041863516 @default.
- W4380884065 hasAuthorship W4380884065A5050971981 @default.
- W4380884065 hasAuthorship W4380884065A5060809049 @default.
- W4380884065 hasAuthorship W4380884065A5070632299 @default.
- W4380884065 hasAuthorship W4380884065A5079534445 @default.
- W4380884065 hasBestOaLocation W43808840651 @default.
- W4380884065 hasConcept C118552586 @default.
- W4380884065 hasConcept C119060515 @default.
- W4380884065 hasConcept C126322002 @default.
- W4380884065 hasConcept C144024400 @default.
- W4380884065 hasConcept C149923435 @default.
- W4380884065 hasConcept C169900460 @default.
- W4380884065 hasConcept C207103383 @default.
- W4380884065 hasConcept C2779134260 @default.
- W4380884065 hasConcept C2779483572 @default.
- W4380884065 hasConcept C2984863031 @default.
- W4380884065 hasConcept C2984915365 @default.
- W4380884065 hasConcept C44249647 @default.
- W4380884065 hasConcept C50382708 @default.
- W4380884065 hasConcept C67739388 @default.
- W4380884065 hasConcept C71924100 @default.
- W4380884065 hasConcept C74909509 @default.
- W4380884065 hasConceptScore W4380884065C118552586 @default.
- W4380884065 hasConceptScore W4380884065C119060515 @default.
- W4380884065 hasConceptScore W4380884065C126322002 @default.
- W4380884065 hasConceptScore W4380884065C144024400 @default.
- W4380884065 hasConceptScore W4380884065C149923435 @default.
- W4380884065 hasConceptScore W4380884065C169900460 @default.
- W4380884065 hasConceptScore W4380884065C207103383 @default.
- W4380884065 hasConceptScore W4380884065C2779134260 @default.
- W4380884065 hasConceptScore W4380884065C2779483572 @default.
- W4380884065 hasConceptScore W4380884065C2984863031 @default.
- W4380884065 hasConceptScore W4380884065C2984915365 @default.
- W4380884065 hasConceptScore W4380884065C44249647 @default.
- W4380884065 hasConceptScore W4380884065C50382708 @default.
- W4380884065 hasConceptScore W4380884065C67739388 @default.
- W4380884065 hasConceptScore W4380884065C71924100 @default.
- W4380884065 hasConceptScore W4380884065C74909509 @default.
- W4380884065 hasIssue "S8" @default.
- W4380884065 hasLocation W43808840651 @default.
- W4380884065 hasOpenAccess W4380884065 @default.
- W4380884065 hasPrimaryLocation W43808840651 @default.
- W4380884065 hasRelatedWork W182016951 @default.
- W4380884065 hasRelatedWork W2005101102 @default.
- W4380884065 hasRelatedWork W2133235702 @default.
- W4380884065 hasRelatedWork W2158317759 @default.
- W4380884065 hasRelatedWork W2346048686 @default.
- W4380884065 hasRelatedWork W2561267217 @default.
- W4380884065 hasRelatedWork W2947523721 @default.
- W4380884065 hasRelatedWork W2969546739 @default.
- W4380884065 hasRelatedWork W3037194828 @default.
- W4380884065 hasRelatedWork W4385271147 @default.
- W4380884065 hasVolume "19" @default.
- W4380884065 isParatext "false" @default.
- W4380884065 isRetracted "false" @default.
- W4380884065 workType "article" @default.