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- W4380896698 abstract "<i>Background/Aims: </i>Despite many therapeutic attempts, post-retrograde cholangiopancreatography pancreatitis (PEP) has remained as a major challenge in interventional endoscopy. This study aimed to compare the effects of intravenous somatostatin plus rectal diclofenac with rectal diclofenac alone in the prevention of PEP.<i> Methods: </i>In a double-blind, randomized clinical trial, patients candidate for ERCP who accepted the study protocol were enrolled in the study between 2019 and 2021. The exclusion criteria include a history of pancreatobiliary surgery, ERCP, acute pancreatitis, contraindication, sensitivity to somatostatin, diclofenac, and pregnancy. PEP was defined as abdominal pain with elevated amylase level. Patients who received intravenous somatostatin plus diclofenac and diclofenac alone enrolled in case group and control group respectively. Patients were followed up for 24h after the procedure. Data regarding demographic, clinical presentation and laboratories results were recorded and compared.<i> Results: </i>A total 186 patients were enrolled, 91 in the case group and 95 as controls. There was no statistically significant difference between the two groups in terms of PEP incidence, complications or changes in serum amylase level (p > 0.05).<i> Conclusion: </i>Rectal diclofenac combined with intravenous somatostatin was superior to rectal diclofenac alone to prevent PE, but without a statistically significant difference, which is probably due to the synergic effect of somatostatin and diclofenac." @default.
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- W4380896698 date "2023-03-20" @default.
- W4380896698 modified "2023-09-23" @default.
- W4380896698 title "Effect of Somatostatin Plus Diclofenac in Comparison with Diclofenac Before ERCP on the Pancreatitis Double Blinded Randomized Clinical Trial" @default.
- W4380896698 doi "https://doi.org/10.11648/j.ijg.20230701.12" @default.
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