Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380985466> ?p ?o ?g. }
- W4380985466 abstract "Anti-metabotropic glutamate receptor 5 (mGluR5) encephalitis is a rare and under-recognized autoimmune encephalitis. This study is conducted to characterize its clinical and neuroimaging features.Twenty-nine patients with anti-mGluR5 encephalitis (15 new cases identified in this study and 14 previously reported cases) were included in this study and their clinical features were characterized. Brain MRI volumetric analysis using FreeSurfer software was performed in 9 new patients and compared with 25 healthy controls at both early (≤6 months of onset) and chronic (>1 year of onset) disease stages.The common clinical manifestations of anti-mGluR5 encephalitis included cognitive deficits (n = 21, 72.4%), behavioral and mood disturbances (n = 20, 69%), seizures (n = 16, 55.2%), and sleep disorder (n = 13, 44.8%). Tumors were observed in 7 patients. Brain MRI T2/FLAIR signal hyperintensities were observed predominantly in mesiotemporal and subcortical regions in 75.9% patients. MRI volumetric analysis demonstrated significant amygdala enlargement in both early and chronic disease stages compared to healthy controls (P < 0.001). Twenty-six patients had complete or partial recovery, one remained stable, one died and one was lost to follow-up.Our findings demonstrated that cognitive impairment, behavioral disturbance, seizures, and sleep disorder are the prominent clinical manifestations of anti-mGluR5 encephalitis. Most patients showed a good prognosis with full recovery, even in the paraneoplastic disease variants. The amygdala enlargement in the early and chronic disease stages is a distinct MRI feature, which exploratively offer a valuable perspective for the study of the disease processes." @default.
- W4380985466 created "2023-06-17" @default.
- W4380985466 creator A5033045696 @default.
- W4380985466 creator A5052256402 @default.
- W4380985466 creator A5053802523 @default.
- W4380985466 creator A5064851872 @default.
- W4380985466 creator A5066978012 @default.
- W4380985466 creator A5081924740 @default.
- W4380985466 creator A5084653738 @default.
- W4380985466 creator A5090109443 @default.
- W4380985466 date "2023-06-16" @default.
- W4380985466 modified "2023-10-11" @default.
- W4380985466 title "Clinical features and brain MRI volumetric changes in anti‐mGluR5 encephalitis" @default.
- W4380985466 cites W1557451274 @default.
- W4380985466 cites W1601599625 @default.
- W4380985466 cites W1965371655 @default.
- W4380985466 cites W1989982790 @default.
- W4380985466 cites W1994308963 @default.
- W4380985466 cites W1996642120 @default.
- W4380985466 cites W2009224548 @default.
- W4380985466 cites W2016196890 @default.
- W4380985466 cites W2023247734 @default.
- W4380985466 cites W2026015335 @default.
- W4380985466 cites W2043166209 @default.
- W4380985466 cites W2057608998 @default.
- W4380985466 cites W2062746952 @default.
- W4380985466 cites W2072818925 @default.
- W4380985466 cites W2075429637 @default.
- W4380985466 cites W2076445235 @default.
- W4380985466 cites W2081234982 @default.
- W4380985466 cites W2087529205 @default.
- W4380985466 cites W2098117168 @default.
- W4380985466 cites W2099502405 @default.
- W4380985466 cites W2101306571 @default.
- W4380985466 cites W2102251915 @default.
- W4380985466 cites W2113319997 @default.
- W4380985466 cites W2114398221 @default.
- W4380985466 cites W2134869941 @default.
- W4380985466 cites W2143285990 @default.
- W4380985466 cites W2147259071 @default.
- W4380985466 cites W2151721316 @default.
- W4380985466 cites W2156711593 @default.
- W4380985466 cites W2168406554 @default.
- W4380985466 cites W2187671472 @default.
- W4380985466 cites W2280783985 @default.
- W4380985466 cites W2571042818 @default.
- W4380985466 cites W2800596677 @default.
- W4380985466 cites W2803681583 @default.
- W4380985466 cites W2872768846 @default.
- W4380985466 cites W2899840633 @default.
- W4380985466 cites W2960042868 @default.
- W4380985466 cites W3037856278 @default.
- W4380985466 cites W3101045033 @default.
- W4380985466 cites W3155605213 @default.
- W4380985466 doi "https://doi.org/10.1002/acn3.51831" @default.
- W4380985466 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37329164" @default.
- W4380985466 hasPublicationYear "2023" @default.
- W4380985466 type Work @default.
- W4380985466 citedByCount "0" @default.
- W4380985466 crossrefType "journal-article" @default.
- W4380985466 hasAuthorship W4380985466A5033045696 @default.
- W4380985466 hasAuthorship W4380985466A5052256402 @default.
- W4380985466 hasAuthorship W4380985466A5053802523 @default.
- W4380985466 hasAuthorship W4380985466A5064851872 @default.
- W4380985466 hasAuthorship W4380985466A5066978012 @default.
- W4380985466 hasAuthorship W4380985466A5081924740 @default.
- W4380985466 hasAuthorship W4380985466A5084653738 @default.
- W4380985466 hasAuthorship W4380985466A5090109443 @default.
- W4380985466 hasBestOaLocation W43809854661 @default.
- W4380985466 hasConcept C101070640 @default.
- W4380985466 hasConcept C118552586 @default.
- W4380985466 hasConcept C126322002 @default.
- W4380985466 hasConcept C126838900 @default.
- W4380985466 hasConcept C142724271 @default.
- W4380985466 hasConcept C143409427 @default.
- W4380985466 hasConcept C146638467 @default.
- W4380985466 hasConcept C170493617 @default.
- W4380985466 hasConcept C203014093 @default.
- W4380985466 hasConcept C2522874641 @default.
- W4380985466 hasConcept C2779134260 @default.
- W4380985466 hasConcept C2781460105 @default.
- W4380985466 hasConcept C41653306 @default.
- W4380985466 hasConcept C49051014 @default.
- W4380985466 hasConcept C58693492 @default.
- W4380985466 hasConcept C61174792 @default.
- W4380985466 hasConcept C71924100 @default.
- W4380985466 hasConcept C83455156 @default.
- W4380985466 hasConceptScore W4380985466C101070640 @default.
- W4380985466 hasConceptScore W4380985466C118552586 @default.
- W4380985466 hasConceptScore W4380985466C126322002 @default.
- W4380985466 hasConceptScore W4380985466C126838900 @default.
- W4380985466 hasConceptScore W4380985466C142724271 @default.
- W4380985466 hasConceptScore W4380985466C143409427 @default.
- W4380985466 hasConceptScore W4380985466C146638467 @default.
- W4380985466 hasConceptScore W4380985466C170493617 @default.
- W4380985466 hasConceptScore W4380985466C203014093 @default.
- W4380985466 hasConceptScore W4380985466C2522874641 @default.
- W4380985466 hasConceptScore W4380985466C2779134260 @default.
- W4380985466 hasConceptScore W4380985466C2781460105 @default.
- W4380985466 hasConceptScore W4380985466C41653306 @default.