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- W4380986058 abstract "The patient acceptable symptom state (PASS) is a reliable way to characterize a patient's satisfaction with their disease state in a Yes/No dichotomous manner. There is limited data on the time required to reach an acceptable state in Myasthenia Gravis (MG). We aimed to determine the time to reach a first PASS Yes response in patients at MG diagnosis and a PASS No status, and also to determine the influence of various factors on this time.We performed a retrospective study of patients diagnosed with myasthenia gravis who had an initial PASS No response and defined the time to reach a first PASS Yes by Kaplan-Meier analysis. Correlations were made between demographics, clinical characteristics, treatment and disease severity, using the Myasthenia Gravis Impairment Index (MGII) and Simple Single Question (SSQ).In 86 patients meeting inclusion criteria, the median time to PASS Yes was 15 months (95% CI 11-18). Of 67 MG patients who achieved PASS Yes, 61 (91%), achieved it by 25 months after diagnosis. Patients who required only prednisone therapy achieved PASS Yes in a shorter time with a median of 5.5 months (p = 0.01). Very-late-onset MG patients reached PASS Yes status in a shorter time (HR = 1.99, 95% CI 0.26-2.63; p = 0.001).Most patients reached PASS Yes by 25 months after diagnosis. MG patients who only required prednisone and those with very-late-onset MG reach PASS Yes in shorter intervals." @default.
- W4380986058 created "2023-06-17" @default.
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- W4380986058 date "2023-06-16" @default.
- W4380986058 modified "2023-09-26" @default.
- W4380986058 title "Time to achieve a patient acceptable symptom state in myasthenia gravis" @default.
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- W4380986058 doi "https://doi.org/10.3389/fneur.2023.1187189" @default.
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