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- W4380990772 abstract "Cisplatin is a metal platinum complex commonly used in the field of anti-tumor and one of the most commonly used drugs in combination chemotherapy. However, chemotherapy with Cisplatin induced overexpression of cyclooxygenase-2 (COX-2) protein in tumor cells, which could impair the therapeutic effect of chemotherapy on tumor progression. Here, we presented a novel method for the treatment of ovarian cancer with a self-assembly based nano-system. Cisplatin and tolfenamic acid were each linked to linoleic acid to give them the ability to self-assemble into nanoparticles in water. TPNPs had flexible drug ratio adjustability, homogeneous stability, and high drug loading capacity. Compared with Cisplatin, TPNPs could promote cellular uptake and tumor aggregation, co-induce enhanced apoptosis and tumor growth inhibition by inhibiting COX-2 in the mice xenograft model of human ovarian cancer, and reduce systemic toxicity. Therefore, TPNPs is a promising antitumor drug as a kind of self-assembly nano-prodrug with high drug load." @default.
- W4380990772 created "2023-06-17" @default.
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- W4380990772 date "2023-06-01" @default.
- W4380990772 modified "2023-09-27" @default.
- W4380990772 title "Self-assembly nanoplatform of platinum (Ⅳ) prodrug for enhanced ovarian cancer therapy" @default.
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- W4380990772 doi "https://doi.org/10.1016/j.mtbio.2023.100698" @default.
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