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- W4380991290 endingPage "831" @default.
- W4380991290 startingPage "831" @default.
- W4380991290 abstract "Infection with human T-cell leukemia virus type 1 (HTLV-1) can produce a spectrum of pathological effects ranging from inflammatory disorders to leukemia. In vivo, HTLV-1 predominantly infects CD4+ T-cells. Infectious spread within this population involves the transfer of HTLV-1 virus particles from infected cells to target cells only upon cell-to-cell contact. The viral protein, HBZ, was found to enhance HTLV-1 infection through transcriptional activation of ICAM1 and MYOF, two genes that facilitate viral infection. In this study, we found that HBZ upregulates the transcription of COL4A1, GEM, and NRP1. COL4A1 and GEM are genes involved in viral infection, while NRP1, which encodes neuropilin 1 (Nrp1), serves as an HTLV-1 receptor on target cells but has no reported function on HTLV-1-infected cells. With a focus on Nrp1, cumulative results from chromatin immunoprecipitation assays and analyses of HBZ mutants support a model in which HBZ upregulates NRP1 transcription by augmenting recruitment of Jun proteins to an enhancer downstream of the gene. Results from in vitro infection assays demonstrate that Nrp1 expressed on HTLV-1-infected cells inhibits viral infection. Nrp1 was found to be incorporated into HTLV-1 virions, and deletion of its ectodomain removed the inhibitory effect. These results suggest that inhibition of HTLV-1 infection by Nrp1 is caused by the ectodomain of Nrp1 extended from virus particles, which may inhibit the binding of virus particles to target cells. While HBZ has been found to enhance HTLV-1 infection using cell-based models, there may be certain circumstances in which activation of Nrp1 expression negatively impacts viral infection, which is discussed." @default.
- W4380991290 created "2023-06-17" @default.
- W4380991290 creator A5000445469 @default.
- W4380991290 creator A5008442693 @default.
- W4380991290 creator A5012151896 @default.
- W4380991290 creator A5019158258 @default.
- W4380991290 creator A5022174147 @default.
- W4380991290 creator A5056266297 @default.
- W4380991290 date "2023-06-15" @default.
- W4380991290 modified "2023-09-29" @default.
- W4380991290 title "Upregulation of Neuropilin-1 Inhibits HTLV-1 Infection" @default.
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- W4380991290 doi "https://doi.org/10.3390/pathogens12060831" @default.