Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380991844> ?p ?o ?g. }
- W4380991844 endingPage "10206" @default.
- W4380991844 startingPage "10206" @default.
- W4380991844 abstract "Pulmonary hypertension (PH) is a disease which affects the cardiopulmonary system; it is defined as a mean pulmonary artery pressure (mPAP) > 20 mmHg as measured by right heart catheterization at rest, and is caused by complex and diverse mechanisms. In response to stimuli such as hypoxia and ischemia, the expression and synthesis of endothelin (ET) increase, leading to the activation of various signaling pathways downstream of it and producing effects such as the induction of abnormal vascular proliferation during the development of the disease. This paper reviews the regulation of endothelin receptors and their pathways in normal physiological processes and disease processes, and describes the mechanistic roles of ET receptor antagonists that are currently approved and used in clinical studies. Current clinical researches on ET are focused on the development of multi-target combinations and novel delivery methods to improve efficacy and patient compliance while reducing side effects. In this review, future research directions and trends of ET targets are described, including monotherapy and precision medicine." @default.
- W4380991844 created "2023-06-17" @default.
- W4380991844 creator A5022698755 @default.
- W4380991844 creator A5030399311 @default.
- W4380991844 creator A5033681865 @default.
- W4380991844 creator A5061928767 @default.
- W4380991844 creator A5067669061 @default.
- W4380991844 creator A5071698217 @default.
- W4380991844 creator A5073537967 @default.
- W4380991844 date "2023-06-16" @default.
- W4380991844 modified "2023-10-12" @default.
- W4380991844 title "Insights into Endothelin Receptors in Pulmonary Hypertension" @default.
- W4380991844 cites W1492199693 @default.
- W4380991844 cites W1548437752 @default.
- W4380991844 cites W1564587656 @default.
- W4380991844 cites W1908793638 @default.
- W4380991844 cites W1969934580 @default.
- W4380991844 cites W1972509561 @default.
- W4380991844 cites W1973136410 @default.
- W4380991844 cites W1979813283 @default.
- W4380991844 cites W1980762198 @default.
- W4380991844 cites W1989480569 @default.
- W4380991844 cites W2011745027 @default.
- W4380991844 cites W2025252445 @default.
- W4380991844 cites W2028788534 @default.
- W4380991844 cites W2038304860 @default.
- W4380991844 cites W2038527467 @default.
- W4380991844 cites W2041193111 @default.
- W4380991844 cites W2045054211 @default.
- W4380991844 cites W2045818769 @default.
- W4380991844 cites W2045997348 @default.
- W4380991844 cites W2046287467 @default.
- W4380991844 cites W2046393134 @default.
- W4380991844 cites W2051069436 @default.
- W4380991844 cites W2055380781 @default.
- W4380991844 cites W2057857083 @default.
- W4380991844 cites W2061837563 @default.
- W4380991844 cites W2071175492 @default.
- W4380991844 cites W2082055727 @default.
- W4380991844 cites W2086053451 @default.
- W4380991844 cites W2093506915 @default.
- W4380991844 cites W2095831905 @default.
- W4380991844 cites W2104172548 @default.
- W4380991844 cites W2108373798 @default.
- W4380991844 cites W2112585717 @default.
- W4380991844 cites W2119263592 @default.
- W4380991844 cites W2119660510 @default.
- W4380991844 cites W2124275351 @default.
- W4380991844 cites W2135875162 @default.
- W4380991844 cites W2145254726 @default.
- W4380991844 cites W2147733939 @default.
- W4380991844 cites W2151869895 @default.
- W4380991844 cites W2158862125 @default.
- W4380991844 cites W2159978640 @default.
- W4380991844 cites W2162804111 @default.
- W4380991844 cites W2165633975 @default.
- W4380991844 cites W2165946847 @default.
- W4380991844 cites W2286301739 @default.
- W4380991844 cites W2316753212 @default.
- W4380991844 cites W2432571697 @default.
- W4380991844 cites W2498485491 @default.
- W4380991844 cites W2513912936 @default.
- W4380991844 cites W2518911298 @default.
- W4380991844 cites W2548537359 @default.
- W4380991844 cites W2567916801 @default.
- W4380991844 cites W2584358852 @default.
- W4380991844 cites W2589445559 @default.
- W4380991844 cites W2739458618 @default.
- W4380991844 cites W2752352806 @default.
- W4380991844 cites W2789769541 @default.
- W4380991844 cites W2790265910 @default.
- W4380991844 cites W2793471458 @default.
- W4380991844 cites W2796757508 @default.
- W4380991844 cites W2801544272 @default.
- W4380991844 cites W2802230558 @default.
- W4380991844 cites W2813305451 @default.
- W4380991844 cites W2890873445 @default.
- W4380991844 cites W2897504384 @default.
- W4380991844 cites W2901182248 @default.
- W4380991844 cites W2904180601 @default.
- W4380991844 cites W2904280618 @default.
- W4380991844 cites W2909031176 @default.
- W4380991844 cites W2917798522 @default.
- W4380991844 cites W2921688102 @default.
- W4380991844 cites W2938865688 @default.
- W4380991844 cites W2942931819 @default.
- W4380991844 cites W2945738933 @default.
- W4380991844 cites W2950479922 @default.
- W4380991844 cites W2969650624 @default.
- W4380991844 cites W2971757224 @default.
- W4380991844 cites W2972400204 @default.
- W4380991844 cites W2974971559 @default.
- W4380991844 cites W2981338258 @default.
- W4380991844 cites W2983063065 @default.
- W4380991844 cites W2990113818 @default.
- W4380991844 cites W2995516686 @default.
- W4380991844 cites W3004916349 @default.
- W4380991844 cites W3015983913 @default.