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• W4380992037 abstract "Resource competition can be the cause of unintended coupling between co-expressed genetic constructs. Here we report the quantification of the resource load imposed by different mammalian genetic components and identify construct designs with increased performance and reduced resource footprint. We use these to generate improved synthetic circuits and optimise the co-expression of transfected cassettes, shedding light on how this can be useful for bioproduction and biotherapeutic applications. This work provides the scientific community with a framework to consider resource demand when designing mammalian constructs to achieve robust and optimised gene expression." @default.
• W4380992037 created "2023-06-17" @default.
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• W4380992037 date "2023-06-16" @default.
• W4380992037 modified "2023-09-23" @default.
• W4380992037 title "Resource-aware construct design in mammalian cells" @default.
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• W4380992037 doi "https://doi.org/10.1038/s41467-023-39252-4" @default.
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• W4380992037 hasPublicationYear "2023" @default.
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