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• W4380992443 abstract "Abstract Children play an important role in hepatitis A virus (HAV) transmission but, due to frequent asymptomatic or mild courses, these infections are underrecognized in routine surveillance. Here, we analyzed hepatitis A (HA) seroprevalence, vaccination status and demographic determinants and estimated previous HAV infections in a cross-sectional population-based study of children and adolescents with residence in Germany 2014–2017, performing weighted univariable and multivariable logistic regression. Of 3567 participants aged 3–17 years, serological results were available for 3013 (84.5%), vaccination records for 3214 (90.1%) and both for 2721 (76.3%). Of 2721 with complete results, 467 (17.2%) were seropositive, thereof 412 (15.1%) with and 55 (2.0%) without previous HA vaccination, indicating previous HAV infection. Seropositivity was associated with age, residence in Eastern states, high socioeconomic status and migration background with personal migration experience. Participants with migration background and personal migration experience also had the highest odds ratios for previous HAV infection. Germany remains a country with very low HA endemicity. The current vaccination recommendations focusing on individuals with a high risk for HAV exposure (e.g. travelers to endemic countries) or severe disease appear appropriate. Migration and travel patterns as well as the endemicity in other countries influence the domestic situation, warranting further monitoring." @default.
• W4380992443 created "2023-06-17" @default.
• W4380992443 creator A5026382712 @default.
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• W4380992443 date "2023-06-16" @default.
• W4380992443 modified "2023-10-14" @default.
• W4380992443 title "Hepatitis A seroprevalence, vaccination status and demographic determinants in children and adolescents in Germany, 2014–2017, a population-based study" @default.
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• W4380992443 doi "https://doi.org/10.1038/s41598-023-36739-4" @default.
• W4380992443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37328526" @default.
• W4380992443 hasPublicationYear "2023" @default.
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