Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380992788> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W4380992788 endingPage "e17379" @default.
- W4380992788 startingPage "e17379" @default.
- W4380992788 abstract "Cardiovascular disease is one of the leading killers in the world today, and hyperlipidemia is one of the main risk factors. The prevalence of hyperlipidemia is rising dramatically worldwide and is mostly felt in poorer nations. The majority of communities and individuals in Africa are known to turn to ethnomedicine for their medical requirements. The tropical plant Carica papaya, which is grown for its edible, ripe fruit in Africa, was used in folk medicine for treatment of cardiovascular issues as well as a number of serious illnesses. This study assessed the anticholesterolemic property of the ethanolic extracts of Carica papaya leaves, adapting the egg yolk-induced hyperlipidaemia model in Wistar albino rats. This study prepared egg yolk to induce hyperlipidaemia in the Wistar rats, then treated some groups with the extract of Carica papaya leaves, and other groups with the standard drug Fenofibrate. The Wistar rats in the control group were given 2% acacia instead of egg yolk. The total cholesterol, triglycerides, as well as biological and haematological parameters, were determined. The Carica papaya leaves extracts significantly (p<0.05) decreased the total cholesterol and LDL cholesterol levels at all doses administered, but the extract and the standard drug had no significant effect on HDL cholesterol. An inverse relationship between the Carica papaya leaves extract doses and the cholesterol levels was observed placing the efficacy in the order of 100 mg/kg > 250 mg/kg > Fenofibrate (2.29 mg/kg) > 500 mg/kg. With the potential efficacy of Carica papaya leaves extract in the treatment of hypercholesterolemia and, as a result, cardiovascular diseases, more research on bioactive molecule isolation/characterisation for pharmaceutical use or incorporation into functional food products for CVD management is required." @default.
- W4380992788 created "2023-06-17" @default.
- W4380992788 creator A5006922314 @default.
- W4380992788 creator A5016856330 @default.
- W4380992788 creator A5029794384 @default.
- W4380992788 creator A5081581596 @default.
- W4380992788 date "2023-06-01" @default.
- W4380992788 modified "2023-09-25" @default.
- W4380992788 title "Ameliorative effect of ethanolic extract of Carica papaya leaves on hyper-cholesterolemic rats: The egg yolk induced model" @default.
- W4380992788 cites W1537357301 @default.
- W4380992788 cites W1539932485 @default.
- W4380992788 cites W1972323440 @default.
- W4380992788 cites W1980424912 @default.
- W4380992788 cites W2002016237 @default.
- W4380992788 cites W2021119815 @default.
- W4380992788 cites W2026848750 @default.
- W4380992788 cites W2074350445 @default.
- W4380992788 cites W2091513731 @default.
- W4380992788 cites W2133272298 @default.
- W4380992788 cites W2200285648 @default.
- W4380992788 cites W2229591405 @default.
- W4380992788 cites W2261369108 @default.
- W4380992788 cites W2323443523 @default.
- W4380992788 cites W2564832264 @default.
- W4380992788 cites W2606264400 @default.
- W4380992788 cites W2751856056 @default.
- W4380992788 cites W2905151492 @default.
- W4380992788 cites W2964451050 @default.
- W4380992788 cites W3001205257 @default.
- W4380992788 cites W3002428231 @default.
- W4380992788 cites W3091970948 @default.
- W4380992788 cites W3111685510 @default.
- W4380992788 cites W3126486239 @default.
- W4380992788 cites W3195627726 @default.
- W4380992788 doi "https://doi.org/10.1016/j.heliyon.2023.e17379" @default.
- W4380992788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37441376" @default.
- W4380992788 hasPublicationYear "2023" @default.
- W4380992788 type Work @default.
- W4380992788 citedByCount "0" @default.
- W4380992788 crossrefType "journal-article" @default.
- W4380992788 hasAuthorship W4380992788A5006922314 @default.
- W4380992788 hasAuthorship W4380992788A5016856330 @default.
- W4380992788 hasAuthorship W4380992788A5029794384 @default.
- W4380992788 hasAuthorship W4380992788A5081581596 @default.
- W4380992788 hasBestOaLocation W43809927881 @default.
- W4380992788 hasConcept C134018914 @default.
- W4380992788 hasConcept C2778163477 @default.
- W4380992788 hasConcept C2779091943 @default.
- W4380992788 hasConcept C2779231358 @default.
- W4380992788 hasConcept C2781321622 @default.
- W4380992788 hasConcept C31903555 @default.
- W4380992788 hasConcept C55493867 @default.
- W4380992788 hasConcept C555293320 @default.
- W4380992788 hasConcept C556039675 @default.
- W4380992788 hasConcept C59822182 @default.
- W4380992788 hasConcept C71924100 @default.
- W4380992788 hasConcept C86803240 @default.
- W4380992788 hasConceptScore W4380992788C134018914 @default.
- W4380992788 hasConceptScore W4380992788C2778163477 @default.
- W4380992788 hasConceptScore W4380992788C2779091943 @default.
- W4380992788 hasConceptScore W4380992788C2779231358 @default.
- W4380992788 hasConceptScore W4380992788C2781321622 @default.
- W4380992788 hasConceptScore W4380992788C31903555 @default.
- W4380992788 hasConceptScore W4380992788C55493867 @default.
- W4380992788 hasConceptScore W4380992788C555293320 @default.
- W4380992788 hasConceptScore W4380992788C556039675 @default.
- W4380992788 hasConceptScore W4380992788C59822182 @default.
- W4380992788 hasConceptScore W4380992788C71924100 @default.
- W4380992788 hasConceptScore W4380992788C86803240 @default.
- W4380992788 hasIssue "6" @default.
- W4380992788 hasLocation W43809927881 @default.
- W4380992788 hasLocation W43809927882 @default.
- W4380992788 hasOpenAccess W4380992788 @default.
- W4380992788 hasPrimaryLocation W43809927881 @default.
- W4380992788 hasRelatedWork W105373802 @default.
- W4380992788 hasRelatedWork W1993227026 @default.
- W4380992788 hasRelatedWork W2079801296 @default.
- W4380992788 hasRelatedWork W2096204303 @default.
- W4380992788 hasRelatedWork W2329759212 @default.
- W4380992788 hasRelatedWork W2363139708 @default.
- W4380992788 hasRelatedWork W2414713476 @default.
- W4380992788 hasRelatedWork W2600909378 @default.
- W4380992788 hasRelatedWork W4380992788 @default.
- W4380992788 hasRelatedWork W2185359204 @default.
- W4380992788 hasVolume "9" @default.
- W4380992788 isParatext "false" @default.
- W4380992788 isRetracted "false" @default.
- W4380992788 workType "article" @default.